A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided HIFU/Chemo- Synergistic Cancer Therapy

Abstract

High-intensity focused ultrasound (HIFU) is deemed to be a promising noninvasive therapeutic modality for cancers as well as non-neoplastic diseases. However, the accuracy of the technique in the diagnosis and treatment of tumors remains unsatisfactory. HIFU, when combined with multifunctional synergistic agents (SAs), has the potential to be of greater diagnostic and therapeutic efficacy. Here we describe a smart and multifunctional hollow mesoporous Prussian blue (HMPBs) theranostic nanoplatform, the hollow structure of which is capable of encapsulating doxorubicin (DOX) and perfluorohexane (HMPBs-DOX/PFH). In vitro and in vivo studies validated that HMPBs-DOX/PFH can be used as an amplifiable dual-mode imaging contrast agent, which can simultaneously enhance ultrasound (US) and photoacoustic (PA) imaging for guiding and monitoring tumor therapy. When exposed to HIFU, this versatile HMPBs-DOX/PFH agent could increase the cavitation effect and use lower HIFU intensity to achieve coagulative necrosis. Furthermore, it significantly accelerated the release of DOX thereby enhancing chemotherapeutic efficacy and avoiding systemic side effects of the drug. Such a novel theranostic nanoplatform is expected to integrate dual-mode guided imaging with greater therapeutic efficacy and fewer side effects and is very promising for the noninvasive synergistic tumor therapy.

Phospholipid Capped Mesoporous Nanoparticles for Targeted High Intensity Focused Ultrasound Ablation

“…[10, 16] In addition, intense HIFU doses can damage the healthy tissue and cause off-target effects such as skin burns and nerve injury. [17, 18] More importantly, the volume of ablation after treatment with current HIFU methods is relatively large (typically cigar-shaped with dimensions on the order of 1–3 mm × 8–15 mm) and ablates tissue nonspecifically. [1] Thus, HIFU is often not suitable for treating small tumor nodules and micrometastases.…”

Sertraline/ICG‐loaded liposome for dual‐modality imaging and effective chemo‐photothermal combination therapy against metastatic clear cell renal cell carcinoma

“…The Ser/ICG@lip optical property assay showed that this liposome could be used for dual‐modality NIR/PA imaging, which is a highly sensitive and non‐invasive technique. Compared with a single imaging mode, dual‐mode imaging can combine imaging advantages to accurately monitor and evaluate the phototherapeutic process (Cai & Chen, ; Zhang, Wang, et al, ; Zhang, Cai, et al, ).…”

“…The Ser/ICG@lip optical property assay showed that this liposome could be used for dual-modality NIR/PA imaging, which is a highly sensitive and non-invasive technique. Compared with a single imaging mode, dual-mode imaging can combine imaging advantages to accurately monitor and evaluate the phototherapeutic process (Cai & Chen, 2008;Zhang, Cai, et al, 2016). The tumor vascular system is highly permeable, allowing access to liposomes smaller than 500nm to spread outside the blood vessels into the tumor interstitial space (Lombardo, Calandra, Barreca, Magazu, & Kiselev, 2016).…”

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

“…Wang et al reported a thermosensitive hydrogel (called BT-CTS thermogel) that had synergistic PTT/PDT anticancer effect and tissue regenerative activity to facilitate surgical wound healing. [334][335][336][337][338] Applying MRI to HIFU facilitated tumor imaging and IGS. [271,273,274,277,278,332] Zhang et al designed a cisplatin-loaded GERT (C-GERT) combining intraoperative PTT and chemotherapy for patients with advanced ovarian tumors.…”