A Multifunctional Zinc Oxide/Poly(Lactic Acid) Nanocomposite Layer Coated on Magnesium Alloys for Controlled Degradation and Antibacterial Function

Mousa, Hamouda M.; Abdal‐hay, Abdalla; Bartnikowski, Michal; Mohamed, Ibrahim M.A.; Yasin, Ahmed S.; Ivanovski, Sašo; Park, Chan Hee; Kim, Cheol Sang

doi:10.1021/acsbiomaterials.8b00277

Cited by 98 publications

(42 citation statements)

References 65 publications

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“…Therefore, it is necessary to control the degradation rate of magnesium alloys for realizing long-term implantation. At present, surface modifications are considered to be an effective way to improve the corrosion resistance of magnesium alloys [ 9 , 10 , 11 , 12 , 13 , 14 ]. Among all of the various surface modifications, the MAO coatings have been widely employed on Mg alloys due to its metallurgical adhesion to the substrate, good wear resistance, moderate corrosion resistance, and high hardness [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of GelMA Hydrogel Coatings on Corrosion Resistance and Biocompatibility of MAO-Coated Mg Alloys

Weng

et al. 2020

Materials

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Micro-arc oxidation (MAO) treatment is a simple and effective technique to improve the corrosion resistance for magnesium alloys. However, the presence of micro-pores and cracks on the coatings provides paths for corrosive ions to penetrate into and react with the substrate, limiting the long-term corrosion resistance. In this paper, we designed a composite coating with which GelMA hydrogel coatings with varying thicknesses were prepared on the surface of MAO-coated magnesium alloys via a dip-coating method, aiming to improve the biocorrosion resistance and biocompatibility. The surface morphology, the chemical composition of GelMA hydrogels, and the crystallographic structure of magnesium alloys were characterized by scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD), respectively. The corrosion resistance and biocompatibility of all samples were evaluated through electrochemical and biological experiments. The results demonstrated that the addition of GelMA hydrogel could effectively seal the pores and improve the corrosion resistance and biocompatibility of MAO-coated magnesium alloys, especially for the sample with one layer of GelMA hydrogel, showing high cell proliferation rate, and its current density (Icorr) was two orders of magnitude lower than that of the MAO coating. Besides, the balance mechanism between corrosion and protection was proposed. As a result, the GelMA hydrogel coatings are beneficial to the application of MAO-coated magnesium alloys in bone tissue engineering and other fields.

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Section: Introductionmentioning

confidence: 99%

Effect of GelMA Hydrogel Coatings on Corrosion Resistance and Biocompatibility of MAO-Coated Mg Alloys

Weng

et al. 2020

Materials

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“…Apart from antibacterial activities, non‐toxicity is also identified as an most essential requirement in the biomedical application for thermosensitive and antibacterial materials . The cytotoxicity of the synthesized polyamides was evaluated using the typical HeLa cells by MTT method in this investigation.…”

Section: Resultsmentioning

confidence: 99%

Multifunctionalized Polyamides Prepared by Facile Ugi Reaction as Thermosensitive, Biocompatible and Antibacterial Biomaterials

Liu

Zhang

et al. 2020

ChemistrySelect

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A series of multifunctionalized polyamides were facilely prepared by Ugi four‐component polymerization (Ugi‐4CP) in one‐pot method at room temperature using several diacids, aldehydes, 1,4 bis‐(3‐aminopropyl) piperazine and tert‐butyl isocyanide as monomers. The simple combination of monomers in Ugi‐4CP led to formation of nine thermosensitive polyamides in water, and their lower critical solution temperatures (LCSTs) were in range of 13.1‐70.1°C. The LCSTs for the subsequently‐quaternized polyamides (PBA‐800‐Br, PIA‐800‐Br and PCA‐800‐Br) were easily readjusted to the desired value in the inorganic salt solutions. PBA‐800‐Br and PIA‐800‐Br exhibited high antibacterial activity against Gram negative E. coli and Gram positive S. aureus. Confocal laser scanning microscope (CLSM) manifested the clear internalization into the cellular inside for the fluorescent molecule‐labelled polyamides. After 24–72 hours of incubation in polyamide solution, the viability rate of HeLa cells reached up to 80–141%, indicating the excellent biocompatibility. In conclusion, the thermosensitive, antibacterial and biocompatible polyamides have great potential to be used as biomaterials.

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“…Studies in vitro showed that the mouthwash solution containing TiO 2 NPs showed superior antibacterial activity against oral pathogenic microorganisms [151]. Nanoparticles of Zn [152,153], Ag [2,154,155,156,157,158,159,160] synergistic with CHX [161,162] or doxycycline [163] showed significant antibacterial effect in an in vitro subgingival biofilm mode. Hexagonal form of boron nitride (hBN)—referred as “white graphite”—showed high antibiofilm activity on preformed biofilm and exhibited no cytotoxic effect on cells at the concentration range of 0.025–0.1 mg/mL [164].…”

Section: Antimicrobial Applications In Dentistrymentioning

confidence: 99%

Application of Antimicrobial Nanoparticles in Dentistry

2019

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Oral cavity incessantly encounters a plethora of microorganisms. Plaque biofilm—a major cause of caries, periodontitis and other dental diseases—is a complex community of bacteria or fungi that causes infection by protecting pathogenic microorganisms from external drug agents and escaping the host defense mechanisms. Antimicrobial nanoparticles are promising because of several advantages such as ultra-small sizes, large surface-area-to-mass ratio and special physical and chemical properties. To better summarize explorations of antimicrobial nanoparticles and provide directions for future studies, we present the following critical review. The keywords “nanoparticle,” “anti-infective or antibacterial or antimicrobial” and “dentistry” were retrieved from Pubmed, Scopus, Embase and Web of Science databases in the last five years. A total of 172 articles met the requirements were included and discussed in this review. The results show that superior antibacterial properties of nanoparticle biomaterials bring broad prospects in the oral field. This review presents the development, applications and underneath mechanisms of antibacterial nanoparticles in dentistry including restorative dentistry, endodontics, implantology, orthodontics, dental prostheses and periodontal field.

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A Multifunctional Zinc Oxide/Poly(Lactic Acid) Nanocomposite Layer Coated on Magnesium Alloys for Controlled Degradation and Antibacterial Function

Cited by 98 publications

References 65 publications

Effect of GelMA Hydrogel Coatings on Corrosion Resistance and Biocompatibility of MAO-Coated Mg Alloys

Effect of GelMA Hydrogel Coatings on Corrosion Resistance and Biocompatibility of MAO-Coated Mg Alloys

Multifunctionalized Polyamides Prepared by Facile Ugi Reaction as Thermosensitive, Biocompatible and Antibacterial Biomaterials

Application of Antimicrobial Nanoparticles in Dentistry

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