A Multimodal Clinical Approach for the Treatment of Bone Metastases in Solid Tumors

Bianco, Giuliano Lo; Lanza, Ezio; Provenzano, Salvatore; Federico, Manuela; Papa, Alfonso; Imani, Farnad; Shirkhany, Gholamhosein; Laudicella, Riccardo; Quartuccio, Natale

doi:10.5812/aapm-126333

Cited by 4 publications

(3 citation statements)

References 67 publications

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“…Zoledronic acid was also shown to be effective [82]. Other treatments include radionuclides, oral medications (opioids, anticonvulsants, antidepressants, corticosteroids), and interventional procedures [83]. For structurally significant lesions in long bones, surgery may be necessary [74].…”

Section: Bony Metastasis and Primary Bone Cancermentioning

confidence: 99%

Evaluation and Management of Shoulder Dysfunction in Cancer Survivors

Lee,

Stubblefield

2024

Curr Phys Med Rehabil Rep

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Purpose of Review Shoulder dysfunction widely affects function and quality of life of cancer survivors. This paper discusses the etiology, identification, evaluation, and management of the common shoulder impairments seen in cancer survivors, particularly those with breast cancer, head and neck cancer, and Hodgkin lymphoma. Recent Findings Shoulder dysfunction can be caused by a wide range of sources, often as a sequelae of cancer treatments including surgery, systemic therapy, and radiation therapy. These can change the shoulder biomechanics leading to musculoskeletal disorders such as rotator cuff disease and adhesive capsulitis. Other etiologies include neuromuscular complications, such as post-breast surgery pain syndrome and radiation fibrosis syndrome, and lymphovascular disorders such as lymphedema and axillary web syndrome. Metastatic bone disease and primary bone cancer should be considered for those with intense shoulder pain. Detailed history and physical exam, and in some cases, imaging can assist with evaluation of shoulder issues. Exercise, physical and occupation therapy are essential in managing shoulder dysfunction. Summary Shoulder dysfunction can limit function and quality of life for cancer survivors. It is important to consider the possible etiologies as accurate diagnosis is critical for optimal treatment.

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Section: Bony Metastasis and Primary Bone Cancermentioning

confidence: 99%

Evaluation and Management of Shoulder Dysfunction in Cancer Survivors

Lee,

Stubblefield

2024

Curr Phys Med Rehabil Rep

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“…PC-derived bone metastases are often characterized as osteoblastic but usually have an underlying osteoclastic component. They can induce adverse complications, called skeletonrelated events (SRE), including pain, pathological fractures, and paralysis of the spine, which decreases the quality of life and worsens prognosis [10].…”

Section: The Cellular and Molecular Mechanisms In Prostate Cancer: Bo...mentioning

confidence: 99%

Targeting Sphingosine 1-Phosphate Metabolism as a Therapeutic Avenue for Prostate Cancer

Mébarek

Skafi

Brizuela

2023

Cancers

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Prostate cancer (PC) is the second most common cancer in men worldwide. More than 65% of men diagnosed with PC are above 65. Patients with localized PC show high long-term survival, however with the disease progression into a metastatic form, it becomes incurable, even after strong radio- and/or chemotherapy. Sphingosine 1-phosphate (S1P) is a bioactive lipid that participates in all the steps of oncogenesis including tumor cell proliferation, survival, migration, invasion, and metastatic spread. The S1P-producing enzymes sphingosine kinases 1 and 2 (SK1 and SK2), and the S1P degrading enzyme S1P lyase (SPL), have been shown to be highly implicated in the onset, development, and therapy resistance of PC during the last 20 years. In this review, the most important studies demonstrating the role of S1P and S1P metabolic partners in PC are discussed. The different in vitro, ex vivo, and in vivo models of PC that were used to demonstrate the implication of S1P metabolism are especially highlighted. Furthermore, the most efficient molecules targeting S1P metabolism that are under preclinical and clinical development for curing PC are summarized. Finally, the possibility of targeting S1P metabolism alone or combined with other therapies in the foreseeable future as an alternative option for PC patients is discussed. Research Strategy: PubMed from INSB was used for article research. First, key words “prostate & sphingosine” were used and 144 articles were found. We also realized other combinations of key words as “prostate cancer bone metastasis” and “prostate cancer treatment”. We used the most recent reviews to illustrate prostate cancer topic and sphingolipid metabolism overview topic.

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“…Recent advancements in cancer therapy have significantly extended the life expectancy of patients with bone metastases, including spinal metastasis [ 1 ]. Spinal metastases can lead to spinal cord compression and intractable pain, ultimately resulting in the loss of ambulatory function [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a clinical prediction score for perioperative complications following metastatic spinal surgery (PERCOM) score

Takeuchi,

Tarukado,

Matsumoto

et al. 2024

Heliyon

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A Multimodal Clinical Approach for the Treatment of Bone Metastases in Solid Tumors

Cited by 4 publications

References 67 publications

Evaluation and Management of Shoulder Dysfunction in Cancer Survivors

Evaluation and Management of Shoulder Dysfunction in Cancer Survivors

Targeting Sphingosine 1-Phosphate Metabolism as a Therapeutic Avenue for Prostate Cancer

Development of a clinical prediction score for perioperative complications following metastatic spinal surgery (PERCOM) score

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