2024
DOI: 10.3389/ftox.2024.1474583
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A multimodal in vitro approach to assess the safety of oral care products using 2D and 3D cellular models

S. Marceli Leano,
Wanderson De Souza,
Rodrigo De Vecchi
et al.

Abstract: IntroductionPeriodontitis, affecting approximately 3.9 billion individuals globally, significantly impacts quality of life and has raised interest in its potential systemic effects. Sodium perborate, a common component in oral care products for biofilm control, is widely used, though concerns about its safety persist. This study aimed to evaluate the in vitro toxicity of six commercial oral care products and varying concentrations of sodium perborate, utilizing human gingival fibroblasts (HGF) and keratinocyte… Show more

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