“…Previously, non-medical images, such as images of human faces, vegetables, and birds have been denoised with neural network [ 12 , 21 , 22 ], and multilayer perceptron or convolutional neural network have achieved good performance for image denoising of non-medical images. For medical image denoising, there are several studies to use conventional neural network [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. On the other hand, literature survey of Litjens et al shows that, in deep learning with convolutional neural network or CAE, number of applications of image enhancement like image denoising is limited [32] .…”