A multiscale synthesis: characterizing acute cartilage failure under an aggregate tibiofemoral joint loading

Adouni, Malek; Faisal, Tanvir R.; Gaith, Mohamed; Dhaher, Yasin Y.

doi:10.1007/s10237-019-01159-9

Cited by 11 publications

(9 citation statements)

References 76 publications

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“…For more details of the model's development process, please see the ►Supplementary Materials (available online only) and our prior published studies. 35,[37][38][39][40] The aforementioned knee model has been updated with additional features and associated changes to develop the parametric FE model of biomechanical experiments which depict the ACL-R surgery. Accordingly, the model included tibial and femoral tunnels of 9 mm diameter with the exact geometry of BPTB graft, which was incorporated by separating the geometry of the graft from that of PT (►Fig.…”

Section: Finite Elements Models and Simulations Of The Acl-r Surgerymentioning

confidence: 99%

“…3,48 Details on the assigned materials' properties have been given in the ►Supplementary Materials (available online only) as well as our prior investigations. 35,37,38,40 Sampling and Surrogate Modeling:…”

Section: Finite Elements Models and Simulations Of The Acl-r Surgerymentioning

confidence: 99%

“…A previously developed computational model of the knee joint comprising all relevant soft tissues was employed in the present study. 35,37 The knee model includes three bony structures (tibia, femur, and patella) associated with the articular cartilage layers, menisci and the eight principal ligaments, anterior/posterior cruciate ligaments (ACL/PCL), medial/lateral collateral ligaments (LCL/MCL), medial/lateral patellofemoral ligaments (MPFL/LPFL), and patellar tendon and quadriceps ligament (PT/QL). The meshes of tibial, patellar and femoral articular cartilages as well as menisci were extensively refined.…”

Section: Finite Elements Models and Simulations Of The Acl-r Surgerymentioning

confidence: 99%

“…The menisci were considered as transversely isotropic, linearly elastic, and homogeneous material. 35 Multiplicative decomposition of the deformation gradient into elastic and plastic parts is introduced in the present work to create the fiber-reinforced composite model of cartilage. Therefore, a hierarchical hyperelastoplastic composite material starting from tropocollagen molecules level (300 nm) to continuum macrolevel (þ100 µm) has been considered in the proposed model.…”

Section: Materials Propertiesmentioning

confidence: 99%

“…The use of the sensitivity analysis framework is advantageous due to the multifactorial nature of the problem. A calibrated and validated healthy model and an ACL-R model [33][34][35] were used to identify the effect of the femoral tunnel's vertical and horizontal locations, femoral sagittal and coronal orientations, fixation angle and graft pretension on cartilage contact patterns, as estimated during isolated tasks (axial compression). Due to their correlation with cartilage degeneration and OA initiation, 36 the compartmental contact force and area, contact center location, and average and maximum contact stresses were considered as the output variables of interest.…”

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confidence: 99%

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Effect of Surgical Design Variations on the Knee Contact Behavior during Anterior Cruciate Ligament Reconstruction

2021

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In this study, we aimed to develop an in-silico synthesis of the effect of critical surgical design parameters on articular contact behavior for a bone-patellar-tendon-bone anterior cruciate ligament reconstruction (ACL-R) surgery. A previously developed finite element model of the knee joint consisting of all relevant soft tissues was employed. The knee model was further updated with additional features to develop the parametric FE model of the biomechanical experiments that depicted the ACL-R surgery. The parametricity was created involving femoral tunnel architecture (orientations and locations) and graft fixation characteristics (pretension and angle of fixation). A global sensitivity analysis based on variance decomposition was used to investigate the contribution of the surgical parameters to the uncertainty in response to the ACL-R joint. Our examinations indicated that the total contact force was primarily influenced by either combined or individual action of the graft pretension and fixation angle, with a modest contribution of the graft insertion sites. The joint contact center and area were affected mainly by the angle of fixation and the tunnel placements. Graft pretension played the dominant role in the maximum contact pressure variability, an observation that has been well-documented in the literature. Interestingly, the joint contact behavior was almost insensitive to the tunnel's coronal and sagittal orientations. Our data provide an evaluation of how the surgical parameters affect the knee joint's contact behavior after ACL-R and may provide additional information to better explain the occurrence of osteoarthritis as an aftermath of such surgery.

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