A multisensory perspective onto primate pulvinar functions

Froesel, Mathilda; Cappe, Céline; Hamed, Suliann Ben

doi:10.1016/j.neubiorev.2021.02.043

Cited by 66 publications

(57 citation statements)

References 192 publications

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“…While the pulvinar subnucleus of the thalamus is thought to be mainly involved in processing visual stimuli, this region is proposed to also be involved in proprioception and multisensory processing, including pain [35]. This supports the notion that the reduced inferior and lateral pulvinar volumes we observed on the symptomatic side in TN patients may reflect the role of the pulvinar in pain processing.…”

Section: Structural Changes In Tn Patientssupporting

confidence: 87%

Leveraging high-resolution 7-tesla MRI to derive quantitative metrics for the trigeminal nerve and subnuclei of limbic structures in trigeminal neuralgia

et al. 2021

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Background Trigeminal Neuralgia (TN) is a chronic neurological disease that is strongly associated with neurovascular compression (NVC) of the trigeminal nerve near its root entry zone. The trigeminal nerve at the site of NVC has been extensively studied but limbic structures that are potentially involved in TN have not been adequately characterized. Specifically, the hippocampus is a stress-sensitive region which may be structurally impacted by chronic TN pain. As the center of the emotion-related network, the amygdala is closely related to stress regulation and may be associated with TN pain as well. The thalamus, which is involved in the trigeminal sensory pathway and nociception, may play a role in pain processing of TN. The objective of this study was to assess structural alterations in the trigeminal nerve and subregions of the hippocampus, amygdala, and thalamus in TN patients using ultra-high field MRI and examine quantitative differences in these structures compared with healthy controls. Methods Thirteen TN patients and 13 matched controls were scanned at 7-Tesla MRI with high resolution, T1-weighted imaging. Nerve cross sectional area (CSA) was measured and an automated algorithm was used to segment hippocampal, amygdaloid, and thalamic subregions. Nerve CSA and limbic structure subnuclei volumes were compared between TN patients and controls. Results CSA of the posterior cisternal nerve on the symptomatic side was smaller in patients (3.75 mm2) compared with side-matched controls (5.77 mm2, p = 0.006). In TN patients, basal subnucleus amygdala volume (0.347 mm3) was reduced on the symptomatic side compared with controls (0.401 mm3, p = 0.025) and the paralaminar subnucleus volume (0.04 mm3) was also reduced on the symptomatic side compared with controls (0.05 mm3, p = 0.009). The central lateral thalamic subnucleus was larger in TN patients on both the symptomatic side (0.033 mm3) and asymptomatic side (0.035 mm3), compared with the corresponding sides in controls (0.025 mm3 on both sides, p = 0.048 and p = 0.003 respectively). The inferior and lateral pulvinar thalamic subnuclei were both reduced in TN patients on the symptomatic side (0.2 mm3 and 0.17 mm3 respectively) compared to controls (0.23 mm3, p = 0.04 and 0.18 mm3, p = 0.04 respectively). No significant findings were found in the hippocampal subfields analyzed. Conclusions These findings, generated through a highly sensitive 7 T MRI protocol, provide compelling support for the theory that TN neurobiology is a complex amalgamation of local structural changes within the trigeminal nerve and structural alterations in subnuclei of limbic structures directly and indirectly involved in nociception and pain processing.

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Section: Structural Changes In Tn Patientssupporting

confidence: 87%

Leveraging high-resolution 7-tesla MRI to derive quantitative metrics for the trigeminal nerve and subnuclei of limbic structures in trigeminal neuralgia

et al. 2021

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“…Perhaps the most striking finding of this study is that of focal enhancements in the posterior thalamus involving the medial and lateral geniculate nuclei and the pulvinar. That subcortical structures such as the superior colliculus (Wallace et al, 1998; Xu et al, 2014; Yu et al, 2013), inferior colliculus (Gruters & Groh, 2012) and some of the thalamic nuclei, especially the medial pulvinar (Cappe et al, 2009; Dietrich et al, 2013; Froesel et al, 2021), are involved in MS processing is now well-known. However, we typically think of these structures as involved in integration of relatively simple stimuli and it might be considered somewhat surprising to find that thalamic nuclei are playing a prominent role in audio-visual speech processing (although see (Hebb & Ojemann, 2013)).…”

Section: Discussionmentioning

confidence: 99%

Section: Subcortical Audiovisual Enhancementmentioning

confidence: 99%

Neural correlates of multisensory enhancement in audiovisual narrative speech perception: a fMRI investigation

Ross

Molholm

Butler

et al. 2022

Preprint

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This fMRI study investigated the effect of seeing articulatory movements of a speaker while listening to a naturalistic narrative stimulus. It had the goal to identify regions of the language network showing multisensory enhancement under synchronous audiovisual conditions. We expected this enhancement to emerge in regions known to underlie the integration of auditory and visual information such as the posterior superior temporal gyrus as well as parts of the broader language network, including the semantic system. To this end we presented 53 participants with a continuous narration of a story in auditory alone, visual alone, and both synchronous and asynchronous audiovisual speech conditions while recording brain activity using BOLD fMRI. We found multisensory enhancement in an extensive network of regions underlying multisensory integration and parts of the semantic network as well as extralinguistic regions not usually associated with multisensory integration, namely the primary visual cortex and the bilateral amygdala. Analysis also revealed involvement of thalamic brain regions along the visual and auditory pathways more commonly associated with early sensory processing. We conclude that under natural listening conditions, multisensory enhancement not only involves sites of multisensory integration but many regions of the wider semantic network and includes regions associated with extralinguistic sensory, perceptual and cognitive processing.

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“…These diverse cortical and subcortical projections could suggest a role for the pulvinar as an ''information hub'' for intersecting pathways (feedforward and feedback, visual, and more), putatively involved in multisensory and sensorimotor integration and conveying diverse signals to the cortex. 4,5,[33][34][35][36] Yet how these different inputs-L5 versus L6 CT, cortical versus subcortical-interact in the pulvinar in vivo is not presently known.…”

Section: Introductionmentioning

confidence: 99%

Distinct “driving” versus “modulatory” influences of different visual corticothalamic pathways

2021

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Distinct ''driving'' versus ''modulatory'' influences of different visual corticothalamic pathways Graphical abstract Highlights d Corticothalamic neurons (CTs) in layer 5 or 6 of V1 were inactivated in awake mice d Layer 5 (L5), but not layer 6 (L6), CTs ''drive'' visual responses in the pulvinar d Both CT projection pathways to the visual thalamus are retinotopically organized d Driving inputs from L5 CTs and the superior colliculus converge in the lateral pulvinar

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A multisensory perspective onto primate pulvinar functions

Cited by 66 publications

References 192 publications

Leveraging high-resolution 7-tesla MRI to derive quantitative metrics for the trigeminal nerve and subnuclei of limbic structures in trigeminal neuralgia

Leveraging high-resolution 7-tesla MRI to derive quantitative metrics for the trigeminal nerve and subnuclei of limbic structures in trigeminal neuralgia

Neural correlates of multisensory enhancement in audiovisual narrative speech perception: a fMRI investigation

Distinct “driving” versus “modulatory” influences of different visual corticothalamic pathways

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