A Multisensory Stripping Voltammetry Method for Analysis of the Generic Anti-Glaucoma Drug Betoptic

Balashova, L. M.; Kolesnichenko, I. I.; Namiot, V. A.; Doronin, A. N.; Bakunina, N. A.; Kuznetsova, Y.D.; Udaltsov, S. N.

doi:10.1134/s0006350919060046

Cited by 6 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electrochemical inversion methods cannot, in principle, be used for continuous determinations because of the need for sequential stages of accumulation and dissolution; however, they are suitable for performing automatic serial analyzes during certain time intervals if suitable programming equipment is available. , Examples are software-controlled devices that use a stationary mercury drip electrode − and a rotating mercury film electrode. − …”

Section: Methodsmentioning

confidence: 99%

“…Further studies have shown the working capacity and effectiveness of the method, in particular, when analyzing a number of ophthalmic drugs: Visomitin and Lanosterol . An increase in the strength of the complex present in the background increases the height of the peak of the metal dissolution current and, accordingly, decreases its width. − Assessment of the dynamics of changes in their concentration in the lacrimal fluid over time must determine the effective dosage of newly developed analgesic ophthalmic drugs. This study aimed to study the behavioral pharmacokinetics in the lacrimal fluid of an opioid drug, sevoflurane, in pediatric ophthalmology using multisensory stripping voltammetry in patients during strabismus correction surgery.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Development of a Method for Multisensory Stripping Voltammetry in the Analysis of Medical Preparations

Kolesnichenko

2023

ACS Omega

View full text Add to dashboard Cite

For the effective dosage of newly developed ophthalmic drugs, an assessment of the dynamics of their concentration in lacrimal fluid over time is required. To express the detection and identification of drugs, new methods are needed that must meet numerous requirements, not the least of which are selectivity, speed, the absence of false-negative results, and costeffectiveness. The possibility of identifying anesthetics (sevoflurane) in lacrimal fluid has been studied using a new electrochemical method of multisensory inversion voltammetry in the electronic tongue and electronic nose format. The measurements were performed on a planar electrode, which is a three-electrode structure. The solution of the test system consisted of 0.05 M KCl, which contained the metal cations Zn 2+ , Cd 2+ , Pb 2+ , Co 2+ , and Hg 2+ at a concentration of 5 × 10 −5 M. It is shown that this method is effective for the determination of anesthetics, and the dynamics of changes in their concentration over time are examined. This study aimed to research the behavioral pharmacokinetics in the lacrimal fluid of the opioid drug sevoflurane in pediatric ophthalmology using multisensory stripping voltammetry in patients during strabismus correction surgery. The dynamics of changes in their concentrations over time were examined. After the instillation of the anesthetics in patients, their concentrations in the tear fluid remained unchanged within 10 min. The list of organic substances that can be determined by multisensory stripping voltammetry has been extended. The class of organic substances determined by the method of multisensory inversion voltammetry has been expanded.

show abstract