A multistrain probiotic reduces sarcopenia by modulating Wnt signaling biomarkers in patients with chronic heart failure

Karim, Asima; Muhammad, Tahir; Shah, Islam; Khan, Javaidullah; Qaisar, Rizwan

doi:10.1016/j.jjcc.2022.06.006

Cited by 26 publications

(30 citation statements)

References 41 publications

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“…60 Twenty-two studies were double-blind RCTs, [37][38][39][40][41][42][43][44][45][46][47][49][50][51][52][53][54][55][56][57][58]60 of which one was crossover double-blind RCT, 37 one was a single-blind RCT 48 and one was nonblinded. 59 Twelve studies provided probiotics in adults aged 50 years and above, 38,41,43,[47][48][49][50]54,[57][58][59][60] whereas 12 studies in adults below 50 years of age. 37,39,40,42,[44][45][46][51][52][53]55,56 Eight studies were conducted in adults with o...…”

Section: Resultsmentioning

confidence: 99%

“…37,39,40,42,[44][45][46][51][52][53]55,56 Eight studies were conducted in adults with overweight and/or obesity, [42][43][44][45][46]49,50,56 seven in untrained and non-athletic healthy populations, 37,40,41,51,54,55,59 one in resistance-trained individuals, 53 one in individuals with metabolic syndrome and type 2 diabetes 48 or hypertension, 60 one in people with frailty, 38 one in people with low bone mineral density, 58 one in patients with chronic heart failure, 57 one in participants with non-displaced distal radius fracture, 47 one in triathletes 39 and one in volleyball and soccer players. 52 Eleven studies had a treatment duration of 12 weeks, [41][42][43][44][45][46]49,50,54,55,57 three of ...…”

Section: Resultsmentioning

confidence: 99%

“…60 Nine studies assessed muscle mass 37,39,40,42,43,48,54,59,60 and one study assessed appendicular lean mass, 57 and 12 studies assessed total lean mass. 38,41,[44][45][46][49][50][51][52][53]56,58 Body composition assessment was performed via bioelectrical impedance (BIA) in 12 studies 37,[40][41][42][43][48][49][50]52,57,59,60 and dual energy X-ray absorptiometry (DXA) in eight studies, 38,39,[44][45][46]51,53,58 whereas two studies did not report details. 54,56 Three studies assessed handgrip strength, 38,47,57 two bench press 52,…”

Section: Resultsmentioning

confidence: 99%

“…59 Twelve studies provided probiotics in adults aged 50 years and above, 38,41,43,[47][48][49][50]54,[57][58][59][60] whereas 12 studies in adults below 50 years of age. 37,39,40,42,[44][45][46][51][52][53]55,56 Eight studies were conducted in adults with overweight and/or obesity, [42][43][44][45][46]49,50,56 seven in untrained and non-athletic healthy populations, 37,40,41,51,54,55,59 one in resistance-trained individuals, 53 one in individuals with metabolic syndrome and type 2 diabetes 48 or hypertension, 60 one in people with frailty, 38 one in people with low bone mineral density, 58 one in patients with chronic heart failure, 57 one in participants with non-displaced distal radius fracture, 47…”

Section: Resultsmentioning

confidence: 99%

“…38,41,[44][45][46][49][50][51][52][53]56,58 Body composition assessment was performed via bioelectrical impedance (BIA) in 12 studies 37,[40][41][42][43][48][49][50]52,57,59,60 and dual energy X-ray absorptiometry (DXA) in eight studies, 38,39,[44][45][46]51,53,58 whereas two studies did not report details. 54,56 Three studies assessed handgrip strength, 38,47,57 two bench press 52,53 and deadlift one repetition maximum (1RM) strength, 52,53 one squat 52 and leg press 1RM 53 and one knee extension and flexion peak torque. 55 Eleven studies utilized products containing Lactobacillus species only, [38][39][40][44]…”

Section: Resultsmentioning

confidence: 99%

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Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta‐analysis of randomized controlled trials

Prokopidis

Giannos

Kirwan

et al. 2022

J cachexia sarcopenia muscle

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Probiotics have shown potential to counteract sarcopenia, although the extent to which they can influence domains of sarcopenia such as muscle mass and strength in humans is unclear. The aim of this systematic review and meta-analysis was to explore the impact of probiotic supplementation on muscle mass, total lean mass and muscle strength in human adults. A literature search of randomized controlled trials (RCTs) was conducted through PubMed, Scopus, Web of Science and Cochrane Library from inception until June 2022. Eligible RCTs compared the effect of probiotic supplementation versus placebo on muscle and total lean mass and global muscle strength (composite score of all muscle strength outcomes) in adults (>18 years). To evaluate the differences between groups, a meta-analysis was conducted using the random effects inverse-variance model by utilizing standardized mean differences. Twenty-four studies were included in the systematic review and meta-analysis exploring the effects of probiotics on muscle mass, total lean mass and global muscle strength. Our main analysis (k = 10) revealed that muscle mass was improved following probiotics compared with placebo (SMD: 0.42, 95% CI: 0.10-0.74, I 2 = 57%, P = 0.009), although no changes were revealed in relation to total lean mass (k = 12; SMD: -0.03, 95% CI: À0.19 -0.13, I 2 = 0%, P = 0.69). Interestingly, a significant increase in global muscle strength was also observed among six RCTs (SMD: 0.69, 95% CI: 0.33-1.06, I 2 = 64%, P = 0.0002). Probiotic supplementation enhances both muscle mass and global muscle strength; however, no beneficial effects were observed in total lean mass. Investigating the physiological mechanisms underpinning different ageing groups and elucidating appropriate probiotic strains for optimal gains in muscle mass and strength are warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta‐analysis of randomized controlled trials

Prokopidis

Giannos

Kirwan

et al. 2022

J cachexia sarcopenia muscle

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Gut microbiota in heart failure and related interventions

Chen

Zhang

2023

iMeta

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Heart failure (HF) is a sophisticated syndrome with structural or functional impairment of ventricular filling or ejection of blood, either causing symptoms and signs or being asymptomatic. HF is a major global health issue affecting about 64.3 million people worldwide. The gut microbiota refers to the complex ecosystem of microorganisms, mainly bacteria, in the gut. Studies have revealed that the gut microbiota is associated with many diseases ranging from neurodegenerative diseases to inflammatory bowel disease and cardiovascular diseases. The gut hypothesis of HF suggests that low cardiac output and systemic circulation congestion would cause insufficient intestinal perfusion, leading to ischemia and intestinal barrier dysfunction. The resulting bacterial translocation would contribute to inflammation. Recent studies have refined the hypothesis that changes of metabolites in the gut microbiota have a close relationship with HF. Thus, the gut microbiota has emerged as a potential therapeutic target for HF due to both its critical role in regulating host physiology and metabolism and its pivotal role in the development of HF. This review article aims to provide an overview of the current understanding of the gut microbiota's involvement in HF, including the introduction of the gut hypothesis of HF, its association with HF progression, the potential mechanisms involved mediated by the gut microbiota metabolites, and the impact of various interventions on the gut microbiota, including dietary interventions, probiotic therapy, fecal microbiota transplantation, antibiotics, and so on. While the gut hypothesis of HF is refined with up‐to‐date knowledge and the gut microbiota presents a promising target for HF therapy, further research is still needed to further understand the underlying mechanisms between gut microbiota and HF, the efficacy of these interventions, and contribute to the health of HF patients.

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Probiotics Supplements Improve the Sarcopenia-Related Quality of Life in Older Adults with Age-Related Muscle Decline

Qaisar,

Burki,

Karim

et al. 2024

Calcif Tissue Int

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A multistrain probiotic reduces sarcopenia by modulating Wnt signaling biomarkers in patients with chronic heart failure

Cited by 26 publications

References 41 publications

Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta‐analysis of randomized controlled trials

Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta‐analysis of randomized controlled trials

Gut microbiota in heart failure and related interventions

Probiotics Supplements Improve the Sarcopenia-Related Quality of Life in Older Adults with Age-Related Muscle Decline

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