A NAD(P)H oxidase mimic for catalytic tumor therapy <i>via</i> a deacetylase SIRT7-mediated AKT/GSK3β pathway

Fang, Qi; Liu, Quanyi; Song, Zhimin; Zhang, Xiaojun; Du, Yan

doi:10.1039/d3nr06538c

Nanoscale

2024

DOI: 10.1039/d3nr06538c

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A NAD(P)H oxidase mimic for catalytic tumor therapy via a deacetylase SIRT7-mediated AKT/GSK3β pathway

Qi Fang,

Quanyi Liu,

Zhimin Song

et al.

Abstract: Nicotinamide adenine dinucleotide (NADH) and its phosphorylated form, NADPH, are essential cofactors that play critical roles in cell functions, influencing antioxidation, reductive biosynthesis, and cellular pathways involved in tumor cell...

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Cited by 3 publications

References 77 publications

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Advancements in NADH Oxidase Nanozymes: Bridging Nanotechnology and Biomedical Applications

Li,

He,

Ding

et al. 2024

Adv Healthcare Materials

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Nicotinamide adenine dinucleotide (NADH) oxidase (NOX) is key in converting NADH to NAD+, crucial for various biochemical pathways. However, natural NOXs are costly and unstable. NOX nanozymes offer a promising alternative with potential applications in bio‐sensing, antibacterial treatments, anti‐aging, and anticancer therapies. This review provides a comprehensive overview of the types, functional mechanisms, biomedical applications, and future research perspectives of NOX nanozymes. It also addresses the primary challenges and future directions in the research and development of NOX nanozymes, underscoring the critical need for continued investigation in this promising area. These challenges include optimizing the catalytic efficiency, ensuring biocompatibility, and achieving targeted delivery and controlled activity within biological systems. Additionally, the exploration of novel materials and hybrid structures holds great potential for enhancing the functional capabilities of NOX nanozymes. Future research directions can involve integrating advanced computational modeling with experimental techniques to better understand the underlying mechanisms and to design more effective nanozyme candidates. Collaborative efforts across disciplines such as nanotechnology, biochemistry, and medicine will be essential to unlock the full potential of NOX nanozymes in future biomedical applications.

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Advancements in NADH Oxidase Nanozymes: Bridging Nanotechnology and Biomedical Applications

Li,

He,

Ding

et al. 2024

Adv Healthcare Materials

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Current advances in nanozyme-based nanodynamic therapies for cancer

Zhou,

Feng,

et al. 2025

Acta Biomaterialia

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Fungicidal Activity of Novel 6-Isothiazol-5-ylpyrimidin-4-amine-Containing Compounds Targeting Complex I Reduced Nicotinamide Adenine Dinucleotide Oxidoreductase

Li,

Lv,

et al. 2024

J. Agric. Food Chem.

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To discover novel inhibitors of the complex I reduced nicotinamide adenine dinucleotide (NADH) oxidoreductase as fungicides, a series of 6-isothiazol-5-ylpyrimidin-4-amine-containing compounds were designed using a computer-aided pesticide design method and splicing of substructures from diflumetorim and isotianil. In vitro fungicidal bioassays indicated that compounds T17−T24 showed high inhibitory activity against Rhizoctonia solani with an effective concentration (EC 50 ) value falling between 2.20 and 23.85 μg/mL, which were more active than or equivalent to the lead diflumetorim with its EC 50 of 19.80 μg/mL. In vivo antifungal bioassays demonstrated that, at a concentration of 200 μg/mL, T7 and T21 showed higher inhibition against Pseudoperonospora cubensis than all other compounds, while T23 exhibited the highest inhibition against Sphaerotheca fuliginea. T23 showed an approximately twofold lower inhibition potency against R. solani complex I NADH oxidoreductase than diflumetorim. Molecular docking and transcriptomic analyses indicated that T23 and diflumetorim both might share the same mode of action, targeting NADH oxidoreductase. T23 as a good fungicidal candidate against R. solani is worthy of further investigation.

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A NAD(P)H oxidase mimic for catalytic tumor therapy via a deacetylase SIRT7-mediated AKT/GSK3β pathway

Abstract: Nicotinamide adenine dinucleotide (NADH) and its phosphorylated form, NADPH, are essential cofactors that play critical roles in cell functions, influencing antioxidation, reductive biosynthesis, and cellular pathways involved in tumor cell...

Cited by 3 publications

References 77 publications

Advancements in NADH Oxidase Nanozymes: Bridging Nanotechnology and Biomedical Applications

Advancements in NADH Oxidase Nanozymes: Bridging Nanotechnology and Biomedical Applications

Current advances in nanozyme-based nanodynamic therapies for cancer

Fungicidal Activity of Novel 6-Isothiazol-5-ylpyrimidin-4-amine-Containing Compounds Targeting Complex I Reduced Nicotinamide Adenine Dinucleotide Oxidoreductase

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