A nanoporous gold-based electrochemical aptasensor for sensitive detection of cocaine

Tavakkoli, Nahid; Soltani, Nasrin; Mohammadi, Fatemeh

doi:10.1039/c9ra01292c

Cited by 31 publications

(13 citation statements)

References 47 publications

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“…A similar strategy using carbon-based screen-printed electrodes (SPEs) has been used for other forensic applications, as they are cheap, disposable and have good compatibility with several electrochemical analyzers [ 45 ]. Several authors have used this technique to detect cocaine from body fluids and samples by targeting tertiary amine moiety of cocaine, which requires no incubation and has a rapid response [ 46 , 47 , 48 ]. Carbon-paper electrodes, including molecularly imprinted ones, have been widely used to develop electrochemical sensors for tetrahydrocannabinol (THC) sensing [ 49 , 50 ].…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

et al. 2021

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In the past decade, wearable biosensors have radically changed our outlook on contemporary medical healthcare monitoring systems. These smart, multiplexed devices allow us to quantify dynamic biological signals in real time through highly sensitive, miniaturized sensing platforms, thereby decentralizing the concept of regular clinical check-ups and diagnosis towards more versatile, remote, and personalized healthcare monitoring. This paradigm shift in healthcare delivery can be attributed to the development of nanomaterials and improvements made to non-invasive biosignal detection systems alongside integrated approaches for multifaceted data acquisition and interpretation. The discovery of new biomarkers and the use of bioaffinity recognition elements like aptamers and peptide arrays combined with the use of newly developed, flexible, and conductive materials that interact with skin surfaces has led to the widespread application of biosensors in the biomedical field. This review focuses on the recent advances made in wearable technology for remote healthcare monitoring. It classifies their development and application in terms of electrochemical, mechanical, and optical modes of transduction and type of material used and discusses the shortcomings accompanying their large-scale fabrication and commercialization. A brief note on the most widely used materials and their improvements in wearable sensor development is outlined along with instructions for the future of medical wearables.

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Section: Electrochemical Biosensorsmentioning

confidence: 99%

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

et al. 2021

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“…Cocaine abuse causes adverse effects on humans, such as anxiety, heart failure, and organ damage. Nahid Tavakkoli et al proposed an electrochemical aptasensor dedicated to its detection by immobilization of the 5′-disulfide-functionalized end of an aptamer sequence on a nanoporous gold (NPG) electrode followed by the conjugation of its 3′-amino-functionalized end to 2,5-dihydroxybenzoic acid (DHBA) as the redox probe shown in Figure 6 [ 89 ].…”

Section: Analytes For Nucleic Acids Aptamers In the Modern Medicalmentioning

confidence: 99%

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

Ziółkowski

Jarczewska

Górski

et al. 2021

Sensors

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This paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is followed by the description of the broad spectrum of aptamer-based sensors for the electrochemical detection of various diagnostically relevant analytes, including metal cations, abused drugs, neurotransmitters, cancer, cardiac and coagulation biomarkers, circulating tumor cells, and viruses. We described also possible future perspectives of aptasensors development. This concerns (i) the approaches to lowering the detection limit and improvement of the electrochemical aptasensors selectivity by application of the hybrid aptamer–antibody receptor layers and/or nanomaterials; and (ii) electrochemical aptasensors integration with more advanced microfluidic devices as user-friendly medical instruments for medical diagnostic of the future.

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“…Biosensor type, employed bioreceptor, transducing procedure, and obtained limits of detection (LOD) for target drug are outlined. [67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85]…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

Nanoarchitectonics for Abused‐Drug Biosensors

Moradi

Khalili

Septiani

et al. 2021

Small

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analogs). Illicit drugs cause damaging lifetime alterations in the brain, making it very difficult to overcome the addiction without specialized, medical assistance. Drug addiction is a long-lasting, reverting psychiatric disorder and is a major public health issue affecting many elements in society such as health care, productivity, policing, crimes, and accidents. According to 2008 estimations, roughly, 4 million people are using opium globally and 80% of them are living in Asia. Studies have shown a link between opium use and diverse adverse health effects such as different types of cancers including oral, bladder, lung, and gastric cancers. [5][6][7] Opioid derivatives, morphine, codeine, fentanyl, or buprenorphine are effective analgesics for post-operative and cancer pain relief but several studies have highlighted the link between their long-term administration and high abuse potential. [8] Morphine is the most potent analgesic for chronic pain; however, its clinical use is restricted since the opiate naturally brings about tolerance and has severe withdrawal symptoms with a high risk of relapse. Over-the-counter Rapid, accessible, and highly accurate biosensors for the detection of addictive and abused drugs are needed to reduce the adverse personal and societal impacts of addiction. Modern sensors that utilize next-generation technologies, e.g., nanobiotechnology and nanoarchitectonics, have triggered revolutionary progress in the field as they allow accurate detection and tracking of trace levels of major classes of drugs. This paper reviews advances in the field of biosensors for the detection of commonly abused drugs, both prescribed such as codeine and morphine, and illegal narcotics like cocaine.

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A nanoporous gold-based electrochemical aptasensor for sensitive detection of cocaine

Cited by 31 publications

References 47 publications

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

Nanoarchitectonics for Abused‐Drug Biosensors

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