A Narrative Review: The Effect and Importance of Carotenoids on Aging and Aging-Related Diseases

Bakac, Elif Rabia; Percin, Ece; Gunes-Bayir, Ayse; Dadak, Agnes

doi:10.3390/ijms242015199

Cited by 10 publications

(2 citation statements)

References 121 publications

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“…It is also inevitable that biological functions decline due to ROS and reactive nitrogen species generated from our reliance on oxygen [ 62 ]. Aging is defined as a decline in biological functions due to advancing age [ 62 , 78 ], and the decline can also be associated with a decrease in antioxidant capacity.…”

Section: Active Oxygen/free Radicals and Living Organisms Bio-regulationmentioning

confidence: 99%

Oxidative Stress and Bio-Regulation

Yoshikawa,

You

2024

IJMS

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Reactive oxygen species (ROS) and free radicals work to maintain homeostasis in the body, but their excessive production causes damage to the organism. The human body is composed of a variety of cells totaling over 60 trillion cells. Each cell performs different functions and has a unique lifespan. The lifespan of cells is preprogrammed in their genes, and the death of cells that have reached the end of their lifespan is called apoptosis. This is contrary to necrosis, which is the premature death of cells brought about by physical or scientific forces. Each species has its own unique lifespan, which in humans is estimated to be up to 120 years. Elucidating the mechanism of the death of a single cell will lead to a better understanding of human death, and, conversely, the death of a single cell will lead to exploring the mechanisms of life. In this sense, research on active oxygen and free radicals, which are implicated in biological disorders and homeostasis, requires an understanding of both the physicochemical as well as the biochemical aspects. Based on the discussion above, it is clear to see that active oxygen and free radicals have dual functions of both injuring and facilitating homeostasis in living organisms.

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Section: Active Oxygen/free Radicals and Living Organisms Bio-regulationmentioning

confidence: 99%

Oxidative Stress and Bio-Regulation

Yoshikawa,

You

2024

IJMS

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“…In recent years, more attention has been paid to various natural compounds such as carotenoids, tocopherols, and flavonoids, as well as vitamins (A, C, D, and E) due to their antioxidant properties and potentially beneficial biological activities for inhibiting or treating aging [ 10 , 11 ]. In particular, ascorbic acid is a natural molecule with confirmed antimicrobial, immunomodulatory, anti-inflammatory, and antioxidant properties that have been known since the 1930s.…”

Section: Introductionmentioning

confidence: 99%

A Lombard Variety of Sweet Pepper Regulating Senescence and Proliferation: The Voghera Pepper

De Luca,

Gola,

Azzalin

et al. 2024

Nutrients

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Aging and its related disorders are important issues nowadays and the first cause of this physio-pathological condition is the overproduction of ROS. Ascorbic acid is an antioxidant mediator and its anti-aging proprieties are well known. Our previous data demonstrated that Voghera sweet pepper (VP), a distinctive type of pepper cultivated in Italy, is particularly rich in ascorbic acid. Based on these data, the anti-aging effect mediated by extracts of the edible part of VP was evaluated on an in vitro model of both young and old Normal Human Diploid Fibroblasts (NHDF). Using phase contrast microscopy, we observed that VP may help cells in the maintenance of physiological morphology during aging. Cytofluorimetric analyses revealed that VP extracts led to an increase in DNA synthesis and percentage of living cells, linked to a consequent increase in mitotic events. This hypothesis is supported by the enhancement of PCNA expression levels observed in old, treated fibroblasts, corroborating the idea that this extract could recover a young phenotype in adult fibroblasts, confirmed by the study of p16 and p53 expression levels and TEM analyses. Based on these results, we may suppose that VP can lead to the partial recovery of “young-like” phenotypes in old fibroblasts.

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Nutritional Benefits of Lycopene and Beta‐Carotene: A Comprehensive Overview

Tufail,

Bader Ul Ain,

Noreen

et al. 2024

Food Science & Nutrition

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Certain carotene components, such as lycopene and beta‐carotene, are found in tomatoes, carrots, sweet potatoes, etc. and are good for human health. It gives plants their distinctive red color. A class of lipid‐soluble natural pigments known as carotenoids is the precursor of vitamin A and is vital for antioxidant defense against peroxides in cells and tissues. This review provides an overview of the current state of knowledge and research on the sources, structures, physiochemical properties, absorption and metabolism, functional advantages, and prevention of many diseases associated with lycopene and beta‐carotene. These antioxidants have been linked to a lower risk of cardiovascular disease and cancer, and they also help draw pollinators to flowers. Carrots and sweet potatoes are also rich sources of beta‐carotene, which strengthens the immune system and improves eye health. The vivid color of many plants reproductive organs, including flowers and fruits, is caused by carotenoid, a secondary metabolite that is produced in plastids. The distinctive red color and many other health advantages are attributed to lycopene. When ingested through food or supplements, lycopene and beta‐carotene help manage and prevent a number of diseases, including cancer, metabolic, inflammatory, cardiovascular, hepatic, ophthalmic, skeletal, and infertility disorders. The main point is that toxicity is uncommon, and these carotenoids are generally accepted to be safe at different doses. Including these nutrients in your diet can improve your general health and provide illness prevention.

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A Narrative Review: The Effect and Importance of Carotenoids on Aging and Aging-Related Diseases

Cited by 10 publications

References 121 publications

Oxidative Stress and Bio-Regulation

Oxidative Stress and Bio-Regulation

A Lombard Variety of Sweet Pepper Regulating Senescence and Proliferation: The Voghera Pepper

Nutritional Benefits of Lycopene and Beta‐Carotene: A Comprehensive Overview

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