A nasal spray with alpha-haemolytic streptococci as long term prophylaxis against recurrent otitis media

Tano, Krister; Håkansson, Eva Grahn; Holm, Stig E.; Hellström, Sten

doi:10.1016/s0165-5876(01)00581-x

Cited by 70 publications

(63 citation statements)

References 12 publications

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“…Nasal probiotic sprays have been proposed as a means to alter the upper respiratory tract flora to prevent AOM. A streptococcal spray has been shown to reduce the recurrence of AOM (52); however, a separate intervention did not result in decreased colonization with AOM pathogens or protection against AOM (57). Our data suggest that effective probiotic sprays for AOM prevention would have to contain multiple species or be targeted toward specific pathogens.…”

Section: Discussionmentioning

confidence: 60%

Upper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children

Pettigrew

Laufer

Gent

et al. 2012

Appl Environ Microbiol

165

153

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ABSTRACTThe composition of the upper respiratory tract microbial community may influence the risk for colonization by the acute otitis media (AOM) pathogensStreptococcus pneumoniae,Haemophilus influenzae, andMoraxella catarrhalis. We used culture-independent methods to describe upper respiratory tract microbial communities in healthy children and children with upper respiratory tract infection with and without concurrent AOM. Nasal swabs and data were collected in a cross-sectional study of 240 children between 6 months and 3 years of age. Swabs were cultured forS. pneumoniae, and real-time PCR was used to identifyS. pneumoniae,H. influenzae, andM. catarrhalis. The V1-V2 16S rRNA gene regions were sequenced using 454 pyrosequencing. Microbial communities were described using a taxon-based approach. Colonization byS. pneumoniae,H. influenzae, andM. catarrhaliswas associated with lower levels of diversity in upper respiratory tract flora. We identified commensal taxa that were negatively associated with colonization by each AOM bacterial pathogen and with AOM. The balance of these relationships differed according to the colonizing AOM pathogen and history of antibiotic use. Children with antibiotic use in the past 6 months and a greater abundance of taxa, includingLactococcusandPropionibacterium, were less likely to have AOM than healthy children (odds ratio [OR], 0.46; 95% confidence interval [CI], 0.25 to 0.85). Children with no antibiotic use in the past 6 months, a low abundance ofStreptococcusandHaemophilus, and a high abundance ofCorynebacteriumandDolosigranulumwere less likely to have AOM (OR, 0.51; 95% CI, 0.31 to 0.83). An increased understanding of polymicrobial interactions will facilitate the development of effective AOM prevention strategies.

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Section: Discussionmentioning

confidence: 60%

Upper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children

Pettigrew

Laufer

Gent

et al. 2012

Appl Environ Microbiol

165

153

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“…Tano y cols, realizaron un estudio doble ciego randomizado en niños con OMAR aplicando un aerosol nasal con probióticos usando Streptococcus alfa hemolítico con el objetivo de disminuir los episodios de OMA y la necesidad de inserción de tubos de timpanostomía 9 . Para esto, evaluaron 43 niños menores de 4 años con diagnóstico de OMAR y los dividieron en dos grupos, uno que recibió placebo y otro que recibió Streptococcus alfa hemolítico, una vez al día por 4 meses y se realizó un seguimiento por seis meses.…”

Section: Otitisunclassified

Uso de probióticos en otorrinolaringología

2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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RESUMEN En los humanos las infecciones más frecuentes son las respiratorias, siendo la principal indicación de antibióticos en niños. El uso indiscriminado de antibióticos lleva a la aparición de gérmenes multirresistentes. Uno de los objetivos actuales en salud es la prevención de las enfermedades infecciosas para disminuir el uso de antibióticos. Una estrategia postulada recientemente para prevenir infecciones respiratorias es el uso de probióticos.Palabras clave: Probióticos, otitis, rinosinusitis crónica, rinitis alérgica, infecciones respiratorias altas. ABSTRACT In humans, the most frequent infections are respiratory, being the main indication of antibiotics in children. The indiscriminate use of antibiotics leads to the emergence of multi-resistant germs. One of the current health objectives is the prevention of infectious diseases so we can reduce the use of antibiotics. A potential strategy for preventing respiratory infections is the use of probiotics.

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“…Mechanisms for bacterial interference involve colonisation of normal flora on epithelial cells preventing the adhesion of pathogens, changes in the bacterial environment, production of bactericidal substances and competition for nutritional substances [23,24]. Several studies provide evidence that normal microflora of the nasopharynx may support nonspecific defence systems against infections such as OM [27,59,133,134]. The majority of interfering bacteria include aerobic a-haemolytic streptococci, mostly Streptococcus mitis and Streptococcus sanguis, and anaerobic streptococci such as Peptostreptococcus anaerobius and Prevotella melaninogenica [15,16,24].…”

Section: Bacterial Interferencementioning

confidence: 99%

“…AOM prone children tend to have an increase in Strep. pneumoniae and NTHi [15,134]. Alpha-haemolytic streptococci isolated from eustachian tube openings have a higher interfering activity against AOM pathogens than those from adenoid tissue [24, 30, 132].…”

Section: Bacterial Interferencementioning

confidence: 99%

Otitis Media: A Review, with a Focus on Alternative Treatments

Dicks

Knoetze

Reenen

2009

Probiotics & Antimicro. Prot.

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Otitis media (OM) is the accumulation of fluids in the middle ear, with or without symptoms of inflammation. The infection is caused by dysfunction or obstruction of the eustachian tube and is most commonly diagnosed in children under the age of two. The microbiology of OM differs, with Streptococcus pneumoniae, non-typeable Haemophilus influenzae and Moraxella catarrhalis the most commonly isolated pathogens. The emergence of penicillin-resistant Strep. pneumoniae, β-lactamase-producing strains, Haem. influenzae and Mor. catarrhalis is a major concern and health care costs associated with treatment are substantial, especially in cases of unresponsive treatment as a result of incorrect diagnosis. Alternative treatments such as vaccines and a nasal spray containing α-haemolytic streptococci with antimicrobial activity against OM pathogens, have been developed. The rationale behind such treatments is to induce an appropriate immune response against the pathogens and decrease bacterial colonisation in the nasopharynx. Another approach may be treatment with bacteriocins (natural antimicrobial peptides) or bacteriocin-like inhibitory substances (BLIS) produced by lactic acid bacteria. We have recently described an antibacterial peptide produced by Enterococcus mundtii ST4SA and have published on bacteriocins (enterocins) with antibacterial and antiviral activity. This review discusses the condition OM, summarises current methods used to treat the infection, and suggests alternative safe and natural treatments that need to be explored.

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A nasal spray with alpha-haemolytic streptococci as long term prophylaxis against recurrent otitis media

Cited by 70 publications

References 12 publications

Upper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children

Upper Respiratory Tract Microbial Communities, Acute Otitis Media Pathogens, and Antibiotic Use in Healthy and Sick Children

Uso de probióticos en otorrinolaringología

Otitis Media: A Review, with a Focus on Alternative Treatments

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