A National Registry-Based Epidemiological Study to Evaluate 395 646 Patients Hospitalized Due to Eye Diseases in Poland in 2019

Kamińska, Agnieszka; Pinkas, Jarosław; Goryński, Paweł; Jankowski, Mateusz

doi:10.12659/msm.939351

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…This is a nationwide cross-sectional web-based survey. Data were generated as a part of the scientific project entitled “Poles’ attitudes towards eye diseases-knowledge about eye diseases, awareness of risk factors, prevention” [ 32 ]. Data were collected between 9 and 12 December 2022 using a dedicated web-based research platform managed by a public opinion research company in Poland [ 33 ].…”

Section: Methodsmentioning

confidence: 99%

Awareness of Common Eye Diseases and Their Risk Factors—A Nationwide Cross-Sectional Survey among Adults in Poland

Kamińska

Pinkas

Wrześniewska-Wal

et al. 2023

IJERPH

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Public knowledge and awareness of eye diseases may influence individuals’ behaviors toward the use of eye care services and prevention methods. The objective of this study was to assess the awareness of common eye diseases and their risk factors among adults in Poland as well as to identify factors associated with knowledge of eye diseases. This nationwide cross-sectional web-based survey was carried out in December 2022 on a representative sample of 1076 adults in Poland. Most of the respondents had heard of cataracts (83.6%), glaucoma (80.7%), conjunctivitis (74.3%), and hordeolum (73.8%). Awareness of dry eye syndrome was declared by 50% of respondents, and 40% were aware of retinal detachment. Among the respondents, 32.3% had heard of AMD, and 16.4% had heard of diabetic retinopathy. A lack of awareness of glaucoma was declared by 38.1% of respondents, and 54.3% declared a lack of awareness of risk factors for AMD. Gender, age, and the presence of chronic diseases were the most important factors (p < 0.05) associated with awareness of common eye diseases and risk factors for glaucoma and AMD. This study demonstrated a low level of awareness of common eye diseases among adults in Poland. Personalized communication on eye diseases is needed.

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Section: Methodsmentioning

confidence: 99%

Awareness of Common Eye Diseases and Their Risk Factors—A Nationwide Cross-Sectional Survey among Adults in Poland

Kamińska

Pinkas

Wrześniewska-Wal

et al. 2023

IJERPH

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“…Data on patients' medical conditions are based on a medical diagnosis and coded by physicians using the 10th revision of the International Statistical Classification of Diseases (ICD-10) [25]. A detailed description of the data collection process has been described in previous papers [24,26].…”

Section: Study Design and Data Sourcementioning

confidence: 99%

Epidemiological Characteristics of 101,471 Patients Hospitalized with Chronic Obstructive Pulmonary Disease (COPD) in Poland in 2019: Multimorbidity, Duration of Hospitalization, In-Hospital Mortality

Jankowski,

Bochenek,

Wieczorek

et al. 2023

ARM

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Chronic obstructive pulmonary disease (COPD) is a common lung disease. There is a limited amount of nationwide data on COPD patients in Poland. This study aimed to characterize patients hospitalized with COPD in Poland in 2019 as well as to identify factors associated with the risk of in-hospital death and prolonged hospitalization among patients with COPD. This study is a retrospective database analysis. Data on patients hospitalized with COPD in Poland were obtained from the Nationwide General Hospital Morbidity Dataset. Data on all adults aged ≥40 years with a diagnosis of COPD from a physician (J44 code) were included in the analysis. Data were analyzed separately for patients hospitalized due to COPD (primary diagnosis) and patients with COPD as a comorbidity (secondary diagnosis). Completed medical records were available for 101,471 patients hospitalized with COPD (36.9% were females). Of those, 32% were hospitalized due to COPD. The mean age was 71.4 ± 9.7 years. The mean duration of hospitalization was 9.4 ± 11.4 days (median 7 days). Most of the COPD patients (89.3%) had at least one comorbidity. The in-hospital mortality rate was 6.8%. Older age, presence of cardiovascular diseases, and diseases of the genitourinary system (p < 0.05) were the most important factors associated with the risk of in-hospital death among patients hospitalized due to COPD.

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“…A 2016 report by the Institute of Healthcare suggested that in Poland, the number of AMD patients in 2016 may have reached 2.7 million people, including 273,000 with wAMD. Furthermore, projections indicate that this number could increase to as many as 3.6 million by 2060 [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Ranibizumab Modifies the Expression of Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Mononuclear Cells in Patients with Exudative Age-Related Macular Degeneration

Strzalka-Mrozik,

Paprzycka,

Gruszka

et al. 2024

JCM

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Background: Age-related macular degeneration (AMD) is the leading cause of vision loss in people over 60 years of age. Despite research, the causes of AMD remain unclear. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are known to be involved in AMD development, and anti-vascular endothelial growth factor therapy has revolutionized its treatment. This study aims to analyze the changes in gene expression in MMPs and TIMPS in patients with neovascular AMD before and after three doses of ranibizumab. Methods: The study involved 29 patients with neovascular AMD treated with ranibizumab. Peripheral blood mononuclear cells were collected before treatment and 24 h after the third dose of ranibizumab. We assessed MMP and TIMP gene expression profiles through oligonucleotide microarrays and validated selected differential genes using RT-qPCR. Results: A statistically significant change in the expression of six MMP- and TIMP-related genes was observed using oligonucleotide microarray. The mRNA levels of the two genes with the most significant fold changes, MMP15 and TIMP2, were then quantified using RT-qPCR. The results confirmed a statistically significant increase in MMP15 expression and a decrease in TIMP2 levels, although this change was not statistically significant in the group before and after the third dose of ranibizumab. Conclusion: Ranibizumab affects the systemic expression of MMP and TIMP-related genes in patients with neovascular AMD. Results from our exploratory study suggest that MMP15, in particular, may play a role in the treatment response, but further research is necessary.

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A National Registry-Based Epidemiological Study to Evaluate 395 646 Patients Hospitalized Due to Eye Diseases in Poland in 2019

Cited by 3 publications

References 34 publications

Awareness of Common Eye Diseases and Their Risk Factors—A Nationwide Cross-Sectional Survey among Adults in Poland

Awareness of Common Eye Diseases and Their Risk Factors—A Nationwide Cross-Sectional Survey among Adults in Poland

Epidemiological Characteristics of 101,471 Patients Hospitalized with Chronic Obstructive Pulmonary Disease (COPD) in Poland in 2019: Multimorbidity, Duration of Hospitalization, In-Hospital Mortality

Ranibizumab Modifies the Expression of Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Mononuclear Cells in Patients with Exudative Age-Related Macular Degeneration

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