A nationwide survey on epidemiological characteristics of childhood Henoch–Schönlein purpura in Taiwan

Yang, Yao‐Hsu; Hung, Chih‐Hsing; Hsu, Chi-Feng; Wang, Li‐Chieh; Chuang, Ya Hui; Lin, Yu-Tsan; Chiang, Bor‐Luen

doi:10.1093/rheumatology/keh544

Cited by 166 publications

(122 citation statements)

References 14 publications

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“…Similar to our results, age of patients in other studies 2-4 is between 5-7 years and 55.0-65% of patients are males. [2][3][4] In this study, skin involvement was seen in 100%, joint involvement in 77.5%, GI involvement in 52.5%, and renal involvement in 10.0% of patients. Frequency of different organs involvement in previous studies 2-5 is more or less similar to our study.…”

Section: E148qmentioning

confidence: 87%

Prevalence of the MEFV gene mutations and their clinical correlations in Azeri Turkish patients with childhood Henoch-Schonlein purpura: The role of M680I and E148Q mutations

Rafeey¹,

M²,

Aliyari³

et al. 2015

J Anal Res Clin Med

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Henoch-Shonlein purpura (HSP) is the most common systemic vasculitis of small vessels in childhood leading to involvement of the skin, gastrointestinal (GI) tract, joints, and kidneys. 1 The incidence of this disease is 12.9-15.0 per 100000 children. 2 Its peak incidence is between 2-8 years of age and is more common in males than females. 3 Clinical signs include nonthrombocytopenic purpura with mass distribution in lower extremities and buttocks, arthritis, especially in large joints, GI symptoms, and renal involvement. 3,4 The cause is unknown, but infectious agents, medications, food allergies and insect bites have been implicated in its occurrence. 5

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Section: E148qmentioning

confidence: 87%

Prevalence of the MEFV gene mutations and their clinical correlations in Azeri Turkish patients with childhood Henoch-Schonlein purpura: The role of M680I and E148Q mutations

Rafeey¹,

M²,

Aliyari³

et al. 2015

J Anal Res Clin Med

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show abstract

“…HSP is a kind of systemic small vessel vasculitis and usually benign and self-limited; however, internal organs such as gastrointestinal tract and kidney may be inflicted (Yang et al 2005). Clinical findings of our patients are presented in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Increased Serum Levels of Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Protein-3 in Henoch-Schonlein Purpura

Yıldız

Kural

Aydın

et al. 2008

Tohoku J. Exp. Med.

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TurkeyHenoch-Schönlein purpura (HSP) is a common systemic vasculitis of childhood, and may affect the kidney. Endothelial cell dysfunction and fibrosis is an important part of HSP vasculitis and may account for renal involvement in HSP. Insulin-like growth factor (IGF)-1 enhances the cytokine-induced expression of adhesion molecules in endothelial cells (EC). Besides, IGF-1 may stimulate angiogenesis, fibrosis and tubular formation in EC and IGF-1 increases glomerular filtration rate. We, therefore, investigated the role of IGF-1 and IGF-binding protein-3 (IGFBP-3) in HSP. The study included 44 patients with HSP (30 boys and 14 girls), including 13 patients with proteinuria, 15 patients with hematuria and 16 patients with positive stool occult blood (SOB), and 26 healthy children. Serum levels of IGF-1 and IGFBP-3 levels were significantly higher in HSP than in the controls (147.9 ± 121.6 vs 95.7 ± 67.8 ng/ml, p = 0.024 and 4.4 ± 2.2 vs 2.3 ± 0.9 μ g/ml, p = 0.001, respectively). Serum IGF-1 levels were significantly higher in HSP with proteinuria than those without proteinuria and controls ( p = 0.001 and p = 0.001, respectively). Also, IGFBP-3 levels were greater in HSP with proteinuria compared to those without proteinuria and controls ( p = 0.005 and p = 0.0001). Serum immunoglobulin-A/ complement-C3 ratio was higher in HSP than in the controls ( p = 0.0001) but this ratio did not change according to proteinuria, hematuria or positive SOB. In conclusion, IGF-1 and IGFBP-3 levels could be new markers for determination of renal involvement in HSP.Henoch-Schönlein purpura; insulin-like growth factor-1; insulin-like growth factor-binding protein-3; proteinuria; hematuria. As an inflammatory disease, HenochSchöenlein purpura (HSP) is the most common systemic vasculitis in children characterized by narrowing of the small vessels lumen and IgA deposition (Tizard 1999). Although there seems to be a temporal relationship between HSP and recent respiratory infections, exposure to allergens, drugs, cold and insect bites, pathophysiolo-

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“…The annual incidence of Henoch-Schönlein purpura in Asian children [4.9 per 100,000] and African children [6.2 per 100,000] was significantly lower than Caucasian children [17.8 per 100,000]. In childhood Henoch-Schönlein purpura, the male:female ratio ranges from 1.2−1.6 (Yang et al, 2005). Renal involvement occurs less frequently in children than adulthood (Yang et al, 2005;Pillebout et al, 2002).…”

Section: Incidencementioning

confidence: 99%

“…In childhood Henoch-Schönlein purpura, the male:female ratio ranges from 1.2−1.6 (Yang et al, 2005). Renal involvement occurs less frequently in children than adulthood (Yang et al, 2005;Pillebout et al, 2002). The incidence of nephritis in patients with Henoch-Schönlein purpura has been reported to be 15-62% with an estimated annual incidence of 20.4 per 100,000 children (Gardner-Medwin et al, 2002;Shenoy, Bradbury, et al 2007;Bogdanovic, 2009).…”

Section: Incidencementioning

confidence: 99%

Henoch-Schönlein Purpura Nephritis in Childhood

Zaffanello¹

2011

An Update on Glomerulopathies - Clinical and Treatment Aspects

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A nationwide survey on epidemiological characteristics of childhood Henoch–Schönlein purpura in Taiwan

Cited by 166 publications

References 14 publications

Prevalence of the MEFV gene mutations and their clinical correlations in Azeri Turkish patients with childhood Henoch-Schonlein purpura: The role of M680I and E148Q mutations

Prevalence of the MEFV gene mutations and their clinical correlations in Azeri Turkish patients with childhood Henoch-Schonlein purpura: The role of M680I and E148Q mutations

Increased Serum Levels of Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Protein-3 in Henoch-Schonlein Purpura

Henoch-Schönlein Purpura Nephritis in Childhood

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