A natural compound obtained from Valeriana�jatamansi selectively inhibits glioma stem cells

Qi, Shi-Gang; Quan, Li-Qiu; Cui, Xiaoyue; Li, Hongmei; Zhao, Xudong; Li, Rong‐Tao

doi:10.3892/ol.2019.11239

Cited by 4 publications

(1 citation statement)

References 47 publications

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“…Cedrol also demonstrated this pattern of selectivity, with an IC 50 for CTX TNA2 rat astrocytes more than two-fold higher than its IC 50 values for DBTRG-05MG and RG2 GBM cell lines [ 33 ]. Similarly, the IC 50 values of rupesin E were significantly greater for human cerebellar astrocytes than glioma stem cells [ 45 ]. Finally, matteucinol’s selectivity was cell line-dependent, with seemingly paradoxical selectivity indices of 1.60 and 0.36 for GAMG and U251 cells, respectively, compared to human astrocytes [ 36 ].…”

Section: Challenges and Considerations In The Use Of Natural Substances For Gbm Treatmentmentioning

confidence: 99%

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Zhai

Siddiqui

Abdellatif

et al. 2021

Cancers

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Glioblastoma (GBM) is an aggressive, often fatal astrocyte-derived tumor of the central nervous system. Conventional medical and surgical interventions have greatly improved survival rates; however, tumor heterogeneity, invasiveness, and chemotherapeutic resistance continue to pose clinical challenges. As such, dietary natural substances—an integral component of the lifestyle medicine approach to chronic diseases—are examined as potential chemotherapeutic agents. These heterogenous substances exert anti-GBM effects by upregulating apoptosis and autophagy, inducing cell cycle arrest, interfering with tumor metabolism, and inhibiting proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis. Although these beneficial effects are promising, natural substances’ efficacy in GBM is constrained by their bioavailability and blood–brain barrier permeability; various chemical formulations are proposed to improve their pharmacological properties. Many of the reviewed substances are available as over-the-counter dietary supplements, underscoring their viability as lifestyle interventions. However, clinical trials remain necessary to substantiate the in vitro and in vivo properties of natural substances.

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Section: Challenges and Considerations In The Use Of Natural Substances For Gbm Treatmentmentioning

confidence: 99%

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Zhai

Siddiqui

Abdellatif

et al. 2021

Cancers

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Therapeutic Perspective of Temozolomide Resistance in Glioblastoma Treatment

Qin

Liu

et al. 2021

Cancer Investigation

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Scientific Appraisal and Therapeutic Properties of Plants Utilized for Veterinary Care in Poonch District of Jammu and Kashmir, India

Wani

Farooq

Sarwar

et al. 2022

Biology

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The importance of traditional and indigenous knowledge is acknowledged on a worldwide scale for its coexistence principles and sustainable use techniques. In view of this, the present study is an attempt to document the ethno-veterinary plants used by the tribal communities of Western Himalaya. This study also provides the scientific validation of herbal medicines used in ethno-veterinary practices through a reverse pharmacological approach. A total of 59 informants were selected through a non-probability sampling method. Detailed information on the medicinal plants used in ethno-veterinary practices along with their habits and habitats, part/s used, remedy preparation methods, additives/ingredients used during preparation and administration, dosages administered, and route of administration was collected. Data was analyzed for the Relative Frequency of Citations (RFC), Use Values (UV), Informant Consensus Factor (ICF), and Jaccard Index (JI). Further, a reverse pharmacological approach was used for scientific validations of the documented herbal knowledge of plant species. During the study, 56 plant species belonging to 54 genera and 39 families were documented. Asteraceae was the dominant family followed by Lamiaceae, Amaranthaceae and Fabaceae. Life forms were dominated by herbaceous species and leaves were the most common plant parts used. The highest Relative Frequency of Citations (RFC) and Use Values (UV) were recorded for Brassica rapa L. (Brassicaceae). The Pearson correlation coefficient between RFC and UV shows a strong positive correlation between the proportion of uses of a plant species within a sample of informants and the number of times that a particular use of a plant species was mentioned by the informant. Studies of the biological activity of ethno-veterinary plants can provide clues of promising leads for the isolation and identification of useful compounds that may be developed into pharmaceuticals for human welfare.

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A natural compound obtained from Valeriana�jatamansi selectively inhibits glioma stem cells

Cited by 4 publications

References 47 publications

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook

Therapeutic Perspective of Temozolomide Resistance in Glioblastoma Treatment

Scientific Appraisal and Therapeutic Properties of Plants Utilized for Veterinary Care in Poonch District of Jammu and Kashmir, India

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