A necessidade da imunofluorescência direta no diagnóstico da dermatose bolhosa por IgA

Abstract

A dermatose bolhosa por imunoglobulina da classe A linear (DbIgA) do adulto é uma doença autoimune rara caracterizada por formação de bolhas subepidérmicas e depósito linear de imunoglobulina da classe A (IgA) na zona da membrana basal (ZMB). Por possuir aspectos clínicos e histológicos semelhantes a outras dermatoses bolhosas, principalmente a dermatite herpetiforme e o penfigoide bolhoso, faz-se necessária a realização de imunofluorescência direta para confirmação diagnóstica. Apresenta-se então, neste artigo, relato de caso ilustrando essa necessidade.

Linear IgA and IgG bullous dermatosis

“…However, others have been reported, such as collagen VII, bullous pemphigoid 230 kDa antigen, and laminina. 7 The term linear IgA and IgG dermatosis (LAGD) is proposed for a subtype or variant of the disease that occurs with deposition of both immunoglobulins and that is found more in adults than in children. 7 A study of four patients with IgA and IgG deposition in the BMZ concluded that the clinical and histopathological findings, as well as the target-antigen (97 kDa extracellular domain of BP 180), were similar to patients with LAD.…”

“… 7 The term linear IgA and IgG dermatosis (LAGD) is proposed for a subtype or variant of the disease that occurs with deposition of both immunoglobulins and that is found more in adults than in children. 7 A study of four patients with IgA and IgG deposition in the BMZ concluded that the clinical and histopathological findings, as well as the target-antigen (97 kDa extracellular domain of BP 180), were similar to patients with LAD. 8 For some authors, LAGD and childhood LAD share similar characteristics and are manifested as a bullous, pruritic rash.…”