A neoteric approach for treatment of persistent macular hole using human amniotic membrane

Abstract

Treatment of persistent macular holes is a challenge. Various techniques have been devised to reduce the surgical failure rate. We present a case of persistent macular hole treated with human amniotic membrane (hAM). We performed primary 23 Gauge pars plana vitrectomy surgery with internal limiting membrane peeling and perfluoropropane (C3F8) gas. Two weeks postoperatively, spectral domain optical coherence tomography (SDOCT) showed an open macular hole. A secondary surgery using hAM plug as scaffold and C3F8 gas was performed. Three weeks postoperative follow-up SDOCT showed anatomical closure of the macular hole. This suggests that hAM can be an effective substrate for persistent macular holes.