2022
DOI: 10.21203/rs.3.rs-1926714/v1
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A nested case-control study of untargeted albumin adductomics and acute myeloid leukemia

Abstract: Environmental exposures often produce reactive electrophiles in vivo, leading to oxidative stress, which plays a major role in carcinogenesis. These electrophiles frequently form adducts with human albumin, which can be measured to assess in vivo oxidative stress. Here, we aimed to examine the associations of albumin adducts with acute myeloid leukemia (AML), the most common adult myeloid leukemia with consistent associations with environmental exposures. We conducted a case-control study of 52 incident AML ca… Show more

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