A nested case-control study of polychlorinated biphenyls, organochlorine pesticides, and thyroid cancer in the Janus Serum Bank cohort

Lerro, Catherine C.; Jones, Rena R.; Langseth, Hilde; Grimsrud, Tom Kristian; Engel, Lawrence S.; Sjödin, Andreas; Choo‐Wosoba, Hyoyoung; Albert, Paul S.; Ward, Mary H.

doi:10.1016/j.envres.2018.04.012

Cited by 40 publications

(52 citation statements)

References 44 publications

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“…Heterogeneous results were found among selected studies when the association between pesticide exposure and HNC cancer was evaluated. Some studies did not found evidence of any association between pesticides exposure and HNC ( 16 , 19 , 21 , 22 , 26 ). On the other hand, most of them found a positive association between pesticide exposure with cancer in larynx ( 2 , 20 , 25 ), pharynx ( 17 ), nasal cavity and nasopharynx ( 18 ), and sinonasal areas ( 22 , 24 ).…”

Section: Resultsmentioning

confidence: 99%

“…According to SIGN 50 criteria, 6 selected studies received an overall high-quality ( 2 , 17 , 18 , 20 , 24 , 25 ), 2 studies were considered with accepTable quality ( 22 , 23 ), and 4 studies were classified with a modest quality ( 16 , 19 , 21 , 26 ).…”

Section: Resultsmentioning

confidence: 99%

“…This reduces the probability in to found some positive association, in addition to increasing the possibility of false associations ( 22 ). Finally, studies considered of modest quality presented failures in the verification of individual exposure ( 19 , 21 , 26 , 27 ), and in considering essential confounders for the evaluated outcome ( 19 , 21 , 26 ), reducing the validity and reliability of the presented results ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

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The pesticides use and the risk for head and neck cancer: A review of case-control studies

Leonel

Bonan²,

Pinto³

et al. 2021

Med Oral

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Background Tobacco, alcohol consumption, and HPV infection are the most common risk factors for head and neck cancer (HNC). Despite of this, recent evidences are growing on the association between long-term exposure to pesticides and the risk of chronic diseases, including different types of cancer. The present review evaluated in current literature evidence of an association between exposure to pesticides and the occurrence of HNCs. Material and Methods A literature search of the case-control studies was conducted in the PubMed, Web of science and Cochrane databases. Methodological quality of each study was rated with the Scottish Intercollegiate Guidelines Network (SIGN 50) checklist. Results One thousand and thirty-five studies were identified and twelve met all criteria and, therefore, considered for quality assessment and data extraction. According to SIGN 50 criteria, six studies received an overall high-quality. All the studies considered of high quality found a positive association between exposure to pesticides and different HNC sites, including larynx, pharynx and nasal cavity. In addition, the increased risk was associated with the frequency of exposure. Conclusions Finally, improving pesticide users' awareness of their risks and proper handling, as well as adopting protective measures such as the use of personal protective equipment, appear to be effective in reducing human health damage. Key words: Case control studies, head and neck cancer, pesticides, review, risk factors.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The pesticides use and the risk for head and neck cancer: A review of case-control studies

Leonel

Bonan²,

Pinto³

et al. 2021

Med Oral

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“…After stratification by gender, they found a significant positive association between PCB-118 exposure and the risk of thyroid cancer in the 2nd (serum concentration of 2.43–4.10 ng/g) vs. 1st quartile in females (OR: 1.90; 95% CI: 1.10–3.27) and males (OR: 1.96; 95% CI: 1.16–3.33) [ 54 ]. In a nested case-control study by Lerro et al (2018) PCBs were not associated with thyroid cancer with the exception of congener PCB-114 which was present at low concentrations and inversely associated with thyroid cancer (OR per 1 ng/g increase: 0.78; 95% CI: 0.62–0.97) [ 55 ]. The same study found a positive association between total PCB exposure (OR: 1.25; 95% CI: 1.00–1.56), PCB 138/158 (OR: 4.54; 95% CI: 1.20–17.2) and PCB 153 (OR: 3.47; 95% CI: 1.18–10.2) with thyroid cancer but only among individuals in the youngest birth cohort (individuals born between 1943–1957) [ 55 ].…”

Section: Resultsmentioning

confidence: 99%

“…In a nested case-control study by Lerro et al (2018) PCBs were not associated with thyroid cancer with the exception of congener PCB-114 which was present at low concentrations and inversely associated with thyroid cancer (OR per 1 ng/g increase: 0.78; 95% CI: 0.62–0.97) [ 55 ]. The same study found a positive association between total PCB exposure (OR: 1.25; 95% CI: 1.00–1.56), PCB 138/158 (OR: 4.54; 95% CI: 1.20–17.2) and PCB 153 (OR: 3.47; 95% CI: 1.18–10.2) with thyroid cancer but only among individuals in the youngest birth cohort (individuals born between 1943–1957) [ 55 ]. Similarly, Deziel et al (2020) found no significant association between PCBs and PTC among 250 female incident cases and 250 controls in Connecticut.…”

Section: Resultsmentioning

confidence: 99%

Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview

Alsen

Sinclair

Cooke

et al. 2021

Toxics

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Endocrine disruptive chemicals (EDC) are known to alter thyroid function and have been associated with increased risk of certain cancers. The present study aims to provide a comprehensive overview of available studies on the association between EDC exposure and thyroid cancer. Relevant studies were identified via a literature search in the National Library of Medicine and National Institutes of Health PubMed as well as a review of reference lists of all retrieved articles and of previously published relevant reviews. Overall, the current literature suggests that exposure to certain congeners of flame retardants, polychlorinated biphenyls (PCBs), and phthalates as well as certain pesticides may potentially be associated with an increased risk of thyroid cancer. However, future research is urgently needed to evaluate the different EDCs and their potential carcinogenic effect on the thyroid gland in humans as most EDCs have been studied sporadically and results are not consistent.

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Sociodemographic Disparities in the Diagnostic Management of Pediatric Thyroid Nodules

Moon

Qian

Noel

et al. 2022

JAMA Otolaryngol Head Neck Surg

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ImportanceThyroid cancer is the most common pediatric endocrine malignant neoplasm. Disparities in the workup of thyroid nodules may be significantly associated with thyroid cancer outcomes.ObjectiveTo determine the association of sociodemographic factors with the odds of receiving a biopsy, timeliness of the procedure, and risk of nodule malignancy.Design, Setting, and ParticipantsThis was a retrospective cross-sectional study using insurance claims data from the Optum Clinformatics Data Mart database. The study cohort comprised pediatric patients diagnosed with single thyroid nodules between 2003 and 2020. Data analysis was performed from January 1, 2003, to June 30, 2020.Main Outcomes and MeasuresMultivariable logistic regression models were used to identify demographic variables associated with biopsy and nodule malignant neoplasm. A multivariable linear regression model was used to assess the time between thyroid nodule diagnosis and biopsy.ResultsOf 11 643 children (median [IQR] age at diagnosis or procedure, 15 [12-17] years; 8549 [73.2%] were female and 3126 [26.8%] were male) diagnosed with single thyroid nodules, 2117 (18.2%) received a biopsy. Among the patients who received a biopsy, 304 (14.4%) were found to have a malignant nodule. Greater parental education was associated with a shorter diagnosis-to-biopsy interval (mean difference, −7.24 days; 95% CI, −13.75 to −0.73). Older age at nodule diagnosis (odds ratio [OR], 1.11; 95% CI, 1.09-1.13) and female gender (OR, 1.25; 95% CI, 1.11-1.40) were associated with increased odds of receiving a biopsy, while Black/African American (OR, 0.80; 95% CI, 0.65-0.99) and Hispanic (OR, 0.84; 95% CI, 0.72-0.99) patients had lower odds of receiving a biopsy compared with White patients. Finally, female gender (OR, 1.08; 95% CI, 0.80-1.47) was not associated with lower odds of nodule malignant neoplasm.Conclusions and RelevanceFindings of this cross-sectional study highlight disparities in the diagnostic management of pediatric thyroid nodules. These results call for future work to ensure equitable access to thyroid care for all children.

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A nested case-control study of polychlorinated biphenyls, organochlorine pesticides, and thyroid cancer in the Janus Serum Bank cohort

Abstract: Emissions of PCBs and OC pesticides varied over time. Different risk patterns by birth cohort suggest the potential importance of timing of exposure in thyroid cancer risk. Further evaluation of these associations is warranted.

Cited by 40 publications

References 44 publications

The pesticides use and the risk for head and neck cancer: A review of case-control studies

The pesticides use and the risk for head and neck cancer: A review of case-control studies

Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview

Sociodemographic Disparities in the Diagnostic Management of Pediatric Thyroid Nodules

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