A Network Study of Chinese Medicine Xuesaitong Injection to Elucidate a Complex Mode of Action with Multicompound, Multitarget, and Multipathway

Wang, Linli; Li, Zheng; Zhao, Xiaoping; Liu, Weiwei; Liu, Yufeng; Yang, Jihong; Li, Xiang; Fan, Xiaohui; Cheng, Yiyu

doi:10.1155/2013/652373

Cited by 34 publications

(31 citation statements)

References 39 publications

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“…1, ginsenoside Rb1; 2, ginsenoside R d; 3, ginsenoside R e; 4, ginsenoside R g1; 5, notoginsenoside R 1. It is redrawn in C ytoscape v3.1.0 based on the original published data [Wang et al., ].…”

Section: Single Herb and Herb Pairmentioning

confidence: 99%

Network Pharmacology: A Rosetta Stone for Traditional Chinese Medicine

Hao

Xiao

2014

Drug Development Research

241

129

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Network pharmacology, based on the theory of systems biology, is a new discipline that analyzes the biological network and screens out the nodes of particular interest, with the aim of designing poly-target drug molecule. It emphasizes maximizing drug efficacy and minimizing adverse effect via the multiple regulation of the signaling pathway. Coincidentally, almost all traditional Chinese medicine (TCM) and worldwide ethnomedicine exert therapeutic effect by targeting multiple molecules of the human body. In this overview, we offer a critique on the present perception of TCM and network pharmacology; illustrate the utility of network pharmacology in the study of single herb, medicine pair, and TCM formula; and summarize the recent progress of TCM-based drug discovery inspired by network pharmacology. Network pharmacology could be of great help in decreasing drug attrition rate and thus is essential in rational and cost-effective drug development. We also pinpoint the current TCM issues that could be tackled by the flexible combined use of network pharmacology and relevant disciplines.

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Section: Single Herb and Herb Pairmentioning

confidence: 99%

Network Pharmacology: A Rosetta Stone for Traditional Chinese Medicine

Hao

Xiao

2014

Drug Development Research

241

129

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“…Global scaling normalization was performed with Median Scaling Normalization in ArrayTrack 3.5.0 using a target median value of 1000. The reversal effect of XKA on gene expression in the diabetic models was evaluated with a reverse rate (RR) analysis [13] . This effect was calculated via the follow-…”

Section: Microarray Data Analysismentioning

confidence: 99%

Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach

et al. 2015

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Aim: Xiao-Ke-An (XKA) is a traditional Chinese medicine (TCM) formula for the treatment of type 2 diabetes (T2D), and the effective ingredients and their targets as well as the mechanisms of XKA remain to be elucidated. In this study we investigated the therapeutic mechanisms of XKA in the treatment of T2D in mice using a Fangjiomics approach. Methods: KKAy mice feeding on a high-fat diet were used as models of T2D, and were orally treated with XKA (0.75 or 1.5 g·kg -1 ·d -1 ) for 32 d. Microarray mRNA expression data were obtained from the livers of the mice. Differentially expressed genes (DEGs) were identified by reverse rate analysis and ANOVA analysis. The compounds in XKA were identified by LC-MS analysis or collected from TCM databases. The relationships between the compounds and targets were established by combining the DEGs with information derived from mining literature or herb target databases. Relevant pathways were identified through a Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis using WebGestalt. Results: The compound-target-pathway network based on compounds identified by LC-MS analysis (NCA) included 20 constituent compounds, 46 targets and 36 T2D-related pathways, whereas the compound-target-pathway network based on compounds collected from databases (NCD) consisted of 40 compounds, 68 targets and 21 pathways. In the treatment of T2D, XKA might act mainly by improving carbohydrate and lipid metabolism, as well as ameliorating insulin resistance, inflammation and diabetic vascular complications. Conclusion: The network-based approach reveals complex therapeutic mechanisms of XKA in the treatment of T2D in mice that involve numerous compounds, targets, and signaling pathways.

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“…However, advances in understanding the pathogenesis of the disease have raised the development of new therapeutics, with improved outcomes. Rheumatoid arthritis may quickly progress into a multisystem inflammation with irreversible joint destruction and increase the risk of humanity [4].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Anti-Arthritic Activity of Cissus Quadrangularis Stem Extract

Vaijayanthimala¹,

Sakthipriya²,

Sangameswaran³

2019

Asian J Pharm Clin Res

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Objective: The present investigation deals with the study of in vitro anti-arthritic activity by inhibition of protein denaturation method by bovine serum albumin method and egg albumin method. Cissus quadrangularis Linn plant is a perennial tendril climber with quadrangular stem. It is used in the treatment of gout, syphilis, stomach ache, regularized the menstrual cycle, antimicrobial activity, and piles in Ayurvedic medicine, and traditionally used for the bone fracture.Method: The air-dried powder of C. quadrangularis Linn (stem parts) was extracted using a Soxhlet apparatus with methanol C. quadrangularis (MECQ) and aqueous C. quadrangularis water (AECQ) as solvent. The extracts were concentrated under reduced pressure. The activities were carried out using the following concentration (100, 200, 300, 400, and 500 μg/ml) and compared with diclofenac as standard drug. It has significant in vitro anti-arthritic in both the methods.Result: The extract of C. quadrangularis possessed significant anti-arthritic property in MECQ than compared to AECQ.Conclusion: Activity may be due to the presence of the chemical profile such as phenolic acid, flavonoid (leuteotin), and β-sitosterol. The results of the study have suggested in the use of C. quadrangularis Linn as a potent anti-arthritic in several applications.

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A Network Study of Chinese Medicine Xuesaitong Injection to Elucidate a Complex Mode of Action with Multicompound, Multitarget, and Multipathway

Cited by 34 publications

References 39 publications

Network Pharmacology: A Rosetta Stone for Traditional Chinese Medicine

Network Pharmacology: A Rosetta Stone for Traditional Chinese Medicine

Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach

In Vitro Anti-Arthritic Activity of Cissus Quadrangularis Stem Extract

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