A new 20-membered macrolide produced by a marine-derived <i>Micromonospora</i> strain

Peng, Fei; Wang, Chuanxi; Xie, Yanjun; Jiang, Hong-Lei; Chen, Lujie; Uribe, Paulina; Bull, Alan T.; Goodfellow, Michael; Jiang, Hong; Lian, Yun-Yang

doi:10.1080/14786419.2012.740038

Cited by 19 publications

(8 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A compound called levantilide C (61) has been identified from Micromonospora strain FIM07-0019 collected off the shallow coastal waters of Chile ( Fei et al, 2013 ). The compound was reported to have a good antiproliferative activity against human colon cancer cell line SW620 (IC 50 = 16.4 µM).…”

Section: The Ecological Diversity Of Actinobacteria and Their Nps Aga...mentioning

confidence: 99%

Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review

et al. 2022

View full text Add to dashboard Cite

Colorectal cancer (CRC) is a common, and deadly disease. Despite the improved knowledge on CRC heterogeneity and advances in the medical sciences, there is still an urgent need to cope with the challenges and side effects of common treatments for the disease. Natural products (NPs) have always been of interest for the development of new medicines. Actinobacteria are known to be prolific producers of a wide range of bioactive NPs, and scientific evidence highlights their important protective role against CRC. This review is a holistic picture on actinobacter-derived cytotoxic compounds against CRC that provides a good perspective for drug development and design in near future. This review also describes the chemical structure of 232 NPs presenting anti-CRC activity with the being majority of quinones, lactones, alkaloids, peptides, and glycosides. The study reveals that most of these NPs are derived from marine actinobacteria followed by terrestrial and endophytic actinobacteria, respectively. They are predominantly produced by Streptomyces, Micromonospors, Saliniospors and Actinomadura, respectively, in which Streptomyces, as the predominant contributor generating over 76% of compounds exclusively. Besides it provides a valuable snapshot of the chemical structure-activity relationship of compounds, highlighting the presence or absence of some specific atoms and chemical units in the structure of compounds can greatly influence their biological activities. To the best of our knowledge, this is the first comprehensive review on natural actinobacterial compounds affecting different types of CRC. Our study reveals that the high diversity of actinobacterial strains and their NPs derivatives, described here provides a new perspective and direction for the production of new anti-CRC drugs and paves the way to innovation for drugs discovery in the future. The knowledge obtain from this review can help us to understand the pivotal application of actinobacteria in future drugs development.

show abstract

Section: The Ecological Diversity Of Actinobacteria and Their Nps Aga...mentioning

confidence: 99%

Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Compounds 34 and 35 are cytotoxic toward HCT-116 cells, with IC 50 values of 5.64 μg/mL and 2.58 μg/ mL, respectively. Seven new azalomycin F analogs (36)(37)(38)(39)(40)(41)(42) have been obtained from Streptomyces sp. 211726 [31].…”

Section: Macrolides (Lactones) Lactams and α/γ-Pyronesmentioning

confidence: 99%

Cytotoxic compounds from marine actinomycetes: sources, structures and bioactivity

Qiu

Lan

et al. 2022

Acta Materia Medica

View full text Add to dashboard Cite

Marine actinomycetes produce a substantial number of natural products with cytotoxic activity. Actinomycete strains have been isolated from sources including fishes, coral, sponges, seaweeds, mangroves and sediments. These cytotoxic compounds can be broadly categorized into four classes: polyketides; non-ribosomal peptides and hybrids; isoprenoids and hybrids; and others, among which the majority are polyketides (146 of 254). Twenty-two of the 254 compounds show potent cytotoxicity, with IC50 values at the ng/mL or nM level. This review highlights the sources, structures and antitumor activity of 254 natural products isolated from marine actinomycetes and first reported between 1989 and 2020.

show abstract

“…48 Two years later, levantilide C (52) was isolated from another Micromonospora strain that was isolated from shallow coastal waters near the island of Chiloe, Chile. 49 All reported levantilides showed signicant in vitro antiproliferative activity against different human cancer cell lines (2.6-8.3 mg mL À1 ). 48,49 In 2018, utilizing bioinformatic approaches together with spectroscopic tools led to the isolation and full characterization of neaumycin B (53), a complex polycyclic macrolide with 19 stereo centers from a marinederived Micromonospora strain.…”

Section: Macrolidesmentioning

confidence: 99%

“…49 All reported levantilides showed signicant in vitro antiproliferative activity against different human cancer cell lines (2.6-8.3 mg mL À1 ). 48,49 In 2018, utilizing bioinformatic approaches together with spectroscopic tools led to the isolation and full characterization of neaumycin B (53), a complex polycyclic macrolide with 19 stereo centers from a marinederived Micromonospora strain. Structural characterization of such complex compounds requires selective degradation, crystallization, derivatization, X-ray diffraction analysis, total asymmetric synthesis, or other time-consuming methods to assign the complete stereo-structure.…”

Section: Macrolidesmentioning

confidence: 99%

See 1 more Smart Citation

The genus Micromonospora as a model microorganism for bioactive natural product discovery

et al. 2020

View full text Add to dashboard Cite

show abstract

A new 20-membered macrolide produced by a marine-derived Micromonospora strain

Cited by 19 publications

References 18 publications

Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review

Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review

Cytotoxic compounds from marine actinomycetes: sources, structures and bioactivity

The genus Micromonospora as a model microorganism for bioactive natural product discovery

Contact Info

Product

Resources

About