A New Absorbable Synthetic Substitute With Biomimetic Design for Dural Tissue Repair

Abstract

Dural repair products are evolving from animal tissue-derived materials to synthetic materials as well as from inert to absorbable features; most of them lack functional and structural characteristics compared with the natural dura mater. In the present study, we evaluated the properties and tissue repair performance of a new dural repair product with biomimetic design. The biomimetic patch exhibits unique three-dimensional nonwoven microfiber structure with good mechanical strength and biocompatibility. The animal study showed that the biomimetic patch and commercially synthetic material group presented new subdural regeneration at 90 days, with low level inflammatory response and minimal to no adhesion formation detected at each stage. In the biological material group, no new subdural regeneration was observed and severe adhesion between the implant and the cortex occurred at each stage. In clinical case study, there was no cerebrospinal fluid leakage, and all the postoperation observations were normal. The biomimetic structure and proper rate of degradation of the new absorbable dura substitute can guide the meaningful reconstruction of the dura mater, which may provide a novel approach for dural defect repair.

Performance evaluation of bilayer oxidized regenerated cellulose/poly ε-caprolactone knitted fabric-reinforced composites for dural substitution

“…10,19 ReDuraä is a synthetic poly-Llactide (PLLA) which is produced by electrospinning process. 20,21 From characterizations in this study, TissuDuraä was observed to be a dense-type material which resulted in the greatest density, tensile modulus and strength, but the lowest elongation at break. Although being similarly produced from collagen, DuraGen Plusä has much lower density, tensile modulus and strength (1.99%, 0.04% and 0.15% of TissuDuraä, respectively), but higher elongation at break due to its highly porous structure resulted from the manufacturing process.…”

Absorbable Artificial Dura Versus Nonabsorbable Artificial Dura in Decompressive Craniectomy for Severe Traumatic Brain Injury: A Retrospective Cohort Study in Two Centers

“…However, sutureless absorbable dura also has its advantages of small patches application in some locations difficult to reach, shorter surgery duration and better histomorphologic outcomes (45)(46)(47). A recent study reported a new absorbable dura made of Poly L Lactic Acid which shows good mechanical properties and represents better anti-adhesive property than NormalGEN in preclinical studies (48). Artificial dura made by novel synthetic substitutes is still the important aspect of future research.…”

Enhancement of tendon–bone healing via the combination of biodegradable collagen-loaded nanofibrous membranes and a three-dimensional printed bone-anchoring bolt

“…8,9,23,24 Although enveloping the grafts with periosteum appears to be a promising approach, clinical evidence supporting its use in humans to augment tendon-bone healing is still lacking, and donor site morbidity is an inevi- the tendon graft to promote tendon-bone healing. 18,26 In the current study, we selected collagen and PLGA to build up a nanofibrous membrane and act as a biomimetic periosteum to enhance tissue invasion and cell attachments in the tendonbone tunnel interface.…”