A new alkanol from the endolichenic fungus <i>Daldinia childiae</i>

Zhou, Xuan; Yang, Cailing; Meng, Qingfeng; Liu, Le; Fu, Shulan

doi:10.1002/jccs.202000274

Cited by 5 publications

(8 citation statements)

References 17 publications

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“…The most abundant species, Daldinia childiae complex, was isolated from all individual lichen samples and under all isolation conditions. D. childiae was recovered both from the branch of pine trees and lichen thalli [ 42 , 43 ]. D. childiae has been reported to be a putative saprobe that stays in fresh host-plant tissue without causing the disease symptoms for a long time [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Isolation Conditions on Diversity of Endolichenic Fungal Communities from a Foliose Lichen, Parmotrema tinctorum

Yang

Kim

et al. 2021

JoF

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Endolichenic fungi (ELF) are emerging novel bioresources because their diverse secondary metabolites have a wide range of biological activities. Metagenomic analysis of lichen thalli demonstrated that the conventional isolation method of ELF covers a very limited range of ELF, and the development of an advanced isolation method is needed. The influence of four variables were investigated in this study to determine the suitable conditions for the isolation of more diverse ELF from a radially growing foliose lichen, Parmotrema tinctorum. Four variables were tested: age of the thallus, severity of surface-sterilization of the thallus, size of a thallus fragment for the inoculation, and nutrient requirement. In total, 104 species (1885 strains) of ELF were isolated from the five individual thalli of P. tinctorum collected at five different places. Most of the ELF isolates belong to Sordariomycetes. Because each part of lichen thallus (of different age) has unique ELF species, the whole thallus of the foliose lichen is needed to isolate diverse ELF. Moderate sterilization is appropriate for the isolation of diverse ELF. Inoculation of small fragment (1 mm2) of lichen thallus resulted in the isolation of highest diversity of ELF species compared to larger fragments (100 and 25 mm2). Moreover, ELF species isolated from the small thallus fragments covered all ELF taxa detected from the medium and the large fragments in this study. The use of two media—Bold’s basal medium (nutrient poor) and potato dextrose agar (nutrient rich)—supported the isolation of diverse ELF. Among the tested variables, size of thallus fragment more significantly influenced the isolation of diverse ELF than other three factors. Species composition and richness of ELF communities from different lichen thalli differed from each other in this study.

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Section: Discussionmentioning

confidence: 99%

Effect of Isolation Conditions on Diversity of Endolichenic Fungal Communities from a Foliose Lichen, Parmotrema tinctorum

Yang

Kim

et al. 2021

JoF

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“…Among them, compound 67 exhibited significant cytotoxicity against the L5178 murine lymphoma cell line, with an IC 50 value of 2.7 µM. The isocoumarins (3R,8S)-dihydroxy-3-hydroxymethyl-6-methoxy-4,5-dimethylisochroman-1-one (70), ophioisocoumarin (71), and (R)-3,4-dihydro-4,8-dihydroxy-6-methoxy-4,5-dimethyl-3-methyleneisochromen-1-one (72) were also isolated from the endolichenic fungus O. korrae [30].…”

Section: Simple Aromatic Polyketidesmentioning

confidence: 99%

“…A new brasilane-type sesquiterpenoid glycoside named hypoxyside A (296) was also disclosed as a critical secondary metabolite in another endolichenic fungus in 2019 by Basnet et al [49], and it showed obvious cytotoxic activity against K562, with an IC 50 value of 18.7 µM. The sesquiterpene rel-(1S,4S,5R,7R,10R)-10-desmethyl-1methyl-11-eudesmene (297) was also isolated from the endolichenic fungus Daldinia childiae for the first time as a new compound by Zhou et al in 2020 [70] and exhibited notable α-amylase inhibitory activity. The sesquiterpenoid ophiokorrin (298) was first isolated and identified from the EtOAc extract of O. korrae by Li et al in 2019 [30], and further phytotoxicity studies showed that ophiokorrin (298) could inhibit root elongation during germination, with an IC 50 value of 18.06 µg/mL.…”

Section: Terpenoidsmentioning

confidence: 99%

Endolichenic Fungi: A Promising Medicinal Microbial Resource to Discover Bioactive Natural Molecules—An Update

Zhang,

Ran,

et al. 2024

JoF

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Lichens are some of the most unique fungi and are naturally encountered as symbiotic biological organisms that usually consist of fungal partners (mycobionts) and photosynthetic organisms (green algae and cyanobacteria). Due to their distinctive growth environments, including hot deserts, rocky coasts, Arctic tundra, toxic slag piles, etc., they produce a variety of biologically meaningful and structurally novel secondary metabolites to resist external environmental stresses. The endofungi that live in and coevolve with lichens can also generate abundant secondary metabolites with novel structures, diverse skeletons, and intriguing bioactivities due to their mutualistic symbiosis with hosts, and they have been considered as strategically significant medicinal microresources for the discovery of pharmaceutical lead compounds in the medicinal industry. They are also of great importance in the fundamental research field of natural product chemistry. In this work, we conducted a comprehensive review and systematic evaluation of the secondary metabolites of endolichenic fungi regarding their origin, distribution, structural characteristics, and biological activity, as well as recent advances in their medicinal applications, by summarizing research achievements since 2015. Moreover, the current research status and future research trends regarding their chemical components are discussed and predicted. A systematic review covering the fundamental chemical research advances and pharmaceutical potential of the secondary metabolites from endolichenic fungi is urgently required to facilitate our better understanding, and this review could also serve as a critical reference to provide valuable insights for the future research and promotion of natural products from endolichenic fungi.

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“…Fraction Fr. 14 2. and ribavirin were used as negative and positive controls, respectively) was added to cells and incubated for 2 h prior to infection, aer which cells were infected with inuenza A/ H1N1/WSN/33 virus at an MOI of 0.05.…”

Section: Fermentation Extraction and Isolationmentioning

confidence: 99%

“…[6][7][8][9][10][11][12] The fungus Daldinia species was widely distributed around the world, and a total of 47 taxa in Daldinia were recognized by 2014, 13 however, only a limited number of secondary metabolites were reported from endolichenic fungus Daldinia species found in lichen. [14][15][16] The fungus Daldinia sp. CPCC 400770 was isolated from lichen, collected from Yunnan province, China, and the crude extract of this strain showed antiviral and antibacterial activities in preliminary bioactive assays.…”

Section: Introductionmentioning

confidence: 99%

New phenol and chromone derivatives from the endolichenic fungusDaldiniaspecies and their antiviral activities

Zhang

et al. 2021

RSC Adv.

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A new alkanol from the endolichenic fungus Daldinia childiae

Cited by 5 publications

References 17 publications

Effect of Isolation Conditions on Diversity of Endolichenic Fungal Communities from a Foliose Lichen, Parmotrema tinctorum

Effect of Isolation Conditions on Diversity of Endolichenic Fungal Communities from a Foliose Lichen, Parmotrema tinctorum

Endolichenic Fungi: A Promising Medicinal Microbial Resource to Discover Bioactive Natural Molecules—An Update

New phenol and chromone derivatives from the endolichenic fungusDaldiniaspecies and their antiviral activities

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