A New Antigenic Group of Arthropod-Borne Viruses

Casals, Jordi; Whitman, Loring

doi:10.4269/ajtmh.1960.9.73

Cited by 40 publications

(21 citation statements)

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“…Antigenic studies have shown that NA strains of EEEV differ from those found in SA and that these two geographic variants also differ in biological and epidemiological characteristics (12)(13)(14)38). Genetic and antigenic studies (9,38,55) revealed that NA strains are highly conserved, constituting a unique major lineage, whereas SA strains constitute three major lineages with more antigenic and genetic variation.…”

mentioning

confidence: 99%

Variation in Interferon Sensitivity and Induction among Strains of Eastern Equine Encephalitis Virus

Aguilar¹,

Paessler

Carrara

et al. 2005

J Virol

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Eastern equine encephalitis virus (EEEV) causes human encephalitis in North America (NA), but in South America (SA) it has rarely been associated with human disease, suggesting that SA strains are less virulent. To evaluate the hypothesis that this virulence difference is due to a greater ability of NA strains to evade innate immunity, we compared replication of NA and SA strains in Vero cells pretreated with interferon (IFN). Human IFN-␣, -␤, and -␥ generally exhibited less effect on replication of NA than SA strains, supporting this hypothesis. In the murine model, no consistent difference in IFN induction was observed between NA and SA strains. After infection with most EEEV strains, higher viremia levels and shorter survival times were observed in mice deficient in IFN-␣/␤ receptors than in wild-type mice, suggesting that IFN-␣/␤ is important in controlling replication. In contrast, IFN-␥ receptor-deficient mice infected with NA and SA strains had similar viremia levels and mortality rates to those of wild-type mice, suggesting that IFN-␥ does not play a major role in murine protection. Mice pretreated with poly(I-C), a nonspecific IFN inducer, exhibited dose-dependent protection against fatal eastern equine encephalitis, further evidence that IFN is important in controlling disease. Overall, our in vivo results did not support the hypothesis that NA strains are more virulent in humans due to their greater ability to counteract the IFN response. However, further studies using a better model of human disease are needed to confirm the results of differential human IFN sensitivity obtained in our in vitro experiments.

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confidence: 99%

Variation in Interferon Sensitivity and Induction among Strains of Eastern Equine Encephalitis Virus

Aguilar¹,

Paessler

Carrara

et al. 2005

J Virol

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“…mosquitoes. Casals and Whitman (1960) subsequently demonstrated that this virus is related antigenically to Wyeomyia (Colombia), Cache Valley (Utah), and Kairi (Trinidad) viruses. Relationships among these viruses were based largely on studies of their complement-fixing (CF) antigens.…”

Section: Introductionmentioning

confidence: 92%

Bunyaviridae: The Bunyaviruses

Calisher¹,

Shope²

1988

Laboratory Diagnosis of Infectious Diseases Principles and Practice

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“…in 1966, at the same place in Córdoba from which BUNV (CbaAr‐426) had been recovered in the previous year (Sabattini et al ., ), and the other from a febrile horse in Carmen de Patagones, Buenos Aires province (Calisher et al ., ). KRIV shares epitopes with BUNV (CbaAr‐426), which leads to cross‐reactions (Casals & Whitman, ). Specific antibodies against BUNV and KRIV have been detected in humans, domestic animals and wildlife in Córdoba province (Cámara et al ., ; Tauro et al ., , ).…”

Section: Introductionmentioning

confidence: 99%

Detection of Orthobunyavirus in mosquitoes collected in Argentina

Tauro

Batallán

Rivarola

et al. 2015

Medical Vet Entomology

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Bunyamwera virus (BUNV) (Bunyaviridae, genus Orthobunyavirus, serogroup Bunyamwera) is considered an emerging pathogen for humans and animals in American countries. The CbaAr-426 strain of BUNV was recovered from mosquitoes Ochlerotatus albifasciatus (Diptera: Culicidae) collected in Córdoba province (Argentina), where serological studies detected high seroprevalences in humans and animals. Molecular detection of Orthobunyavirus was performed in mosquitoes collected in Córdoba province. Seventeen mosquito pools of Oc. albifasciatus, Ochlerotatus scapularis and Culex quinquefasciatus (Diptera: Culicidae) showed positive results; four of these positive pools, all of Oc. scapularis, were sequenced. All amplicons grouped with BUNV in the Bunyamwera serogroup. The findings highlight the circulation of BUNV in Córdoba province and represent the first report of BUNV-infected Oc. scapularis mosquitoes in Argentina.

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A New Antigenic Group of Arthropod-Borne Viruses

Cited by 40 publications

References 0 publications

Variation in Interferon Sensitivity and Induction among Strains of Eastern Equine Encephalitis Virus

Variation in Interferon Sensitivity and Induction among Strains of Eastern Equine Encephalitis Virus

Bunyaviridae: The Bunyaviruses

Detection of Orthobunyavirus in mosquitoes collected in Argentina

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