A new approach for preparing a controlled release ketoprofen tablets by using beeswax

Üner, Melike; Gönüllü, Ümit; Yener, Gülgün; Altınkurt, Turan

doi:10.1016/j.farmac.2004.08.008

Cited by 29 publications

(10 citation statements)

References 26 publications

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“…21 The improved dermal uptake of active compounds loaded to NLCs might also result from an increased contact to the surface of the active compound with the corneocytes followed by either a rapid or steady release. 22,23 In Table 2, the amount of remaining tacrolimus is almost same in all the formulations, which means that all the formulations have similar abilities of partitioning into the dermal layers with different penetration rates through the hair follicles.…”

mentioning

confidence: 85%

Investigation of Tacrolimus Loaded Nanostructured Lipid Carriers for Topical Drug Delivery

Nam¹,

Ji²,

Park³

2011

Bulletin of the Korean Chemical Society

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The objective of this investigation was to develop nanostructured lipid carriers (NLCs) of tacrolimus by the hot homogenization technique by sonication. NLCs are commonly prepared by emulsification and lyophilization. The feasibility of fabricating tacrolimus-loaded NLCs was successfully demonstrated in this study. The developed NLCs were characterized in terms of their particle size, zeta potential, entrapment efficiency (EE) of tacrolimus, and morphology. Studies were conducted to evaluate the effectiveness of the NLCs in improving the penetration rate through hairless mouse skin. Tacrolimus-loaded NLCs were found to have an average size of 123.4 ± 0.3 nm, a zeta potential of −24.3 ± 6.2 mV, and an EE of 50%. In vitro penetration tests revealed that the tacrolimus-loaded NLCs have a penetration rate that is 1.64 times that of the commercial tacrolimus ointment, Protopic ® .

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mentioning

confidence: 85%

Investigation of Tacrolimus Loaded Nanostructured Lipid Carriers for Topical Drug Delivery

Nam¹,

Ji²,

Park³

2011

Bulletin of the Korean Chemical Society

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“…Appropriate amount of SLM in 100 ml PBS/propylene glycol (60:40) was placed in an ultrasonic bath at 85 o C to liberate LRT from SLM [9]. After cooling to room temperature, it was filtered through S&S 5893 blue ribbon filter paper.…”

Section: Drug Content Of Microparticlesmentioning

confidence: 99%

Preliminary Studies on Solid Lipid Microparticles of Loratadine for the Treatment of Allergic Reactions via the Nasal Route

Üner¹,

Karaman²

2013

Trop. J. Pharm Res

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Purpose: To formulate solid lipid microparticles (SLM) of loratadine (LRT) for the treatment of allergic reactions via the nasal route. Methods: Microparticles were prepared by emulsion congealing technique. The drug content of microparticles was analysed. Drug/excipient compatibility and crystallinity characteristics of microparticles were investigated by Fourier Transform Infrared Spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Particle size distribution was determined by laser diffraction (LD). Drug release from microparticles was compared to that from conventional vehicles (O/W emulsion

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“…As stated earlier, the mode of drug release from waxy matrices is usually by erosion/diffusion of drugs [8]. There are different possible mechanisms by which this occurs.…”

Section: Discussionmentioning

confidence: 99%

“…Matrix delivery systems utilizing waxy materials usually employ a core of drug embedded in the wax or a compressed physical blend of drug and matrix forming agent. Several inert semi-solid excipients such as animal or vegetable waxes are available, and many have been considered for encapsulation [8].…”

Section: Introductionmentioning

confidence: 99%

Controlled Release Formulation of Indomethacin Prepared With Bee Glue Extracts

Honary¹,

Ebrahimi²,

Naghibi³

et al. 2011

Trop. J. Pharm Res

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A new approach for preparing a controlled release ketoprofen tablets by using beeswax

Cited by 29 publications

References 26 publications

Investigation of Tacrolimus Loaded Nanostructured Lipid Carriers for Topical Drug Delivery

Investigation of Tacrolimus Loaded Nanostructured Lipid Carriers for Topical Drug Delivery

Preliminary Studies on Solid Lipid Microparticles of Loratadine for the Treatment of Allergic Reactions via the Nasal Route

Controlled Release Formulation of Indomethacin Prepared With Bee Glue Extracts

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