2021
DOI: 10.1002/vjch.202000095
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A New Approach for the Synthesis of Sotolon in Racemic and Enantioenriched Forms

Abstract: Sotolon (3‐hydroxy‐4,5‐dimethyl‐2(5H)‐furanone) has been synthezised both in racemic and enantioenriched forms by a short sequence involving intramolecular tandem isomerization‐aldolisation and tandem izomerization/Mannich reactions as key steps. Optically active Sotolon has been obtained by using (S)‐N‐tert‐butane sulfinimine as a chiral starting material.

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