A new approach for the one-step synthesis of bioactive PS vs. PMMA silica hybrid microspheres as potential drug delivery systems

Polymethylmethacrylate (PMMA)/CeO 2 hybrid particles for enhanced chemical mechanical polishing performance

“…Because KPS was used as anionic initiator, the obtained PMMA was negative-charged [18]. During the synthesis process, Ce 3 þ cations could be absorbed onto the surfaces of the negatively charged PMMA cores via electrostatic forces.…”

“…PMMA core particles were prepared by emulsifier-free emulsion polymerization [18]. Briefly, 10 g methyl methacrylate (MMA, purified with an inhibitor removal column prior to use) and 150 ml deionized (DI) water were added into a 250 ml round bottom flask with a reflux condenser and magnetic stirrer.…”

Synthesis of novel quaternary silica hybrid bioactive microspheres

“…The main objective of bone tissue engineering applications was based on the regenerative properties of the bioactive scaffolds, in order to stimulate repair and reconstruction of diseased or damaged bone tissue . To this effect, the key features of bioactive glasses for actual bone regeneration were considered to be (i) the release of ionic dissolution products, (ii) the formation of a surface induced hydroxyapatite (HA) layer, and (iii) the stimulation and progression of osteogenesis …”

“…Thus, in recent studies micron‐sized and nanoscale glass particles were developed and provided several advantages in bone tissue engineering. The most interesting examples were 45S5 Bioglass ® particles that showed potential angiogenic effect and vascularization, mesoporous bioactive glass microspheres which exhibited hemostatic activity, ferromagnetic bioactive glasses that were studied for hyperthermia effect in cancer therapy, and hybrid silicate microspheres that achieved sustained and controlled drug release of anticancer drugs like doxorubicin …”

“…The hybrid scaffolds combined the advantages of their components providing new bioactive materials with favorable formability (such as microspheres) and adequate bioactivity (hydroxyapatite formation). To this concept, in our previous studies hybrid silicate microspheres with poly(styrene) and poly(methyl methacrylate) polymers were prepared that exhibited effective loading and release of doxorubicin and sufficient bioactivity . In order to improve the bioactivity of the hybrid microspheres, our group examined the incorporation of ionic dissolution products (P 5+ , Ca 2+ , and Na 2+ ions) in binary silicate‐based and ternary silicate–phosphate microspheres .…”