A new approach to fabricate bioactive silica binary and ternary hybrid microspheres

Angelopoulou, Athina; Efthimiadou, Eleni K.; Κορδάς, Γ.

doi:10.1016/j.msec.2015.04.014

Cited by 8 publications

(60 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mixture was sustained for about half hour in order to ensure hydrolysis and the progression of condensation. To the reaction mixture proper amounts of calcium nitrate and natrium nitrate dissolved in water were added and left to suspend for 2 h for complete homogenation . Then, another 2.4 mL aq.…”

Section: Methodsmentioning

confidence: 99%

“…The main objective of bone tissue engineering applications was based on the regenerative properties of the bioactive scaffolds, in order to stimulate repair and reconstruction of diseased or damaged bone tissue . To this effect, the key features of bioactive glasses for actual bone regeneration were considered to be (i) the release of ionic dissolution products, (ii) the formation of a surface induced hydroxyapatite (HA) layer, and (iii) the stimulation and progression of osteogenesis …”

Section: Introductionmentioning

confidence: 99%

“…To this concept, in our previous studies hybrid silicate microspheres with poly(styrene) and poly(methyl methacrylate) polymers were prepared that exhibited effective loading and release of doxorubicin and sufficient bioactivity . In order to improve the bioactivity of the hybrid microspheres, our group examined the incorporation of ionic dissolution products (P 5+ , Ca 2+ , and Na 2+ ions) in binary silicate‐based and ternary silicate–phosphate microspheres . The binary and ternary hybrid microspheres exhibited enhanced bone‐like apatite formation, but the ternary systems indicated a faster ionic dissolution rate close to biological apatite.…”

Section: Introductionmentioning

confidence: 99%

“…This observation highlighted the importance of incorporating all the Si 4+ , P 5+ , Ca 2+ , and Na 2+ ions into one system that would mimic the 45S5 Bioglass ® composition. In the hybrid bioactive microspheres developed in our previous studies, no Ca 2+ and Na 2+ ions were incorporated together in the silicate–phosphate network. However, the classical 45S5 Bioglass ® composition has a notable bone regeneration ability, due to the increased amounts of Ca 2+ and Na 2+ ions and the ratio of Ca 2+ /P 5+ that have proved to promote increased reactivity in physiological environments .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the great importance of the ion dissolution products (Si 4+ , P 5+ , Ca 2+ , and Na 2+ ) to bone regeneration from a 45S5 Bioglass ® surface was revealed by the enhanced activation of gene expression in osteogenic cells . In this perspective, the present study was aimed to further examine the development of quaternary silicate–phosphate hybrid microspheres based on our previously established sol–gel coating reaction on poly(styrene) template microspheres …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Synthesis of novel quaternary silica hybrid bioactive microspheres

2016

Self Cite

View full text Add to dashboard Cite

Quaternary hybrid silica microspheres were effectively synthesized. The bioassay evaluation of the final microspheres revealed the rapid in vitro formation of a bone-like apatite layer. The results verify the bioactivity of the microspheres and promote further research of their suitability on regenerative treatment of bone abnormalities. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 112-120, 2018.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Synthesis of novel quaternary silica hybrid bioactive microspheres

2016

Self Cite

View full text Add to dashboard Cite

show abstract

Single subconjunctival injection formulation using sol-gel mesoporous silica as a controlled release system for drop-free post-cataract surgery care

Sun

Huffman

Freeman

et al. 2020

J Cataract Refract Surg

View full text Add to dashboard Cite

Purpose: To develop a mesoporous silica drug delivery system and target drop-free care after cataract surgery with a single subconjunctival injection. Setting: Laboratory.Design: Experimental animal study.Methods: Ketorolac was infiltration-loaded into sol-gel mesoporous silica particles encapsulated with poly(allylamine hydrochloride) and poly(sodium 4-styrenesulfonate) using a layer-by-layer adsorption technique (SG-Ket-LBL). The formulation was subjected to an in vitro and in vivo drug release study in addition to ocular toxicology evaluation.Results: Thermogravimetric analysis revealed that the drug loading efficiency was 4.4% for the SG-Ket-LBL particles. The in vivo safety study demonstrated that the formulation was well tolerated after subconjunctival injection and aqueous humor pharmacokinetics showed sustained therapeutic drug release for the targeted time window of 6 to 8 weeks. Conclusion:Findings indicated that sol-gel mesoporous silica could be used as a drug carrier for subconjunctival administration. The tested formulation, SG-Ket-LBL, provided therapeutic ketorolac for 6 to 8 weeks, which might be used for a single subconjunctival injection to replace nonsteroidal anti-inflammatory drug eyedrops after cataract surgery.

show abstract

<p>Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone</p>

Wang

Zhang

Hao

et al. 2019

IJN

View full text Add to dashboard Cite

The porous surface of a polyetheretherketone (PK)–nanoporous lithium-doped magnesium silicate (NLS) blend (PKNLS) was fabricated on a PK surface by layer-by-layer pressuring, sintering, and salt-leaching. As controls, porous surfaces of a PK/lithium-doped magnesium silicate blend (PKLS) and PK were fabricated using the same method. The results revealed that porosity, water absorption, and protein absorption of the porous surface of PKNLS containing macropores and nanopores were obviously enhanced compared to PKLS and PK containing macropores without nanopores. In addition, PKNLS, with both macroporostiy and nanoporosity, displayed the highest ability of apatite mineralization in simulated body liquid, indicating excellent bioactivity. In vitro responses (including adhesion, proliferation, and differentiation) of MC3T3E1 cells to PKNLS were significantly enhanced compared to PKLS and PK. In vivo implantation results showed that new bone grew into the macroporous surface of PKNLS, and the amount of new bone for PKNLS was the highest. In short, PKNLS integration with PK significantly promoted cells/bone-tissue responses and exhibited excellent osteogenesis in vivo, which might have great potential for bone repair.

show abstract

A new approach to fabricate bioactive silica binary and ternary hybrid microspheres

Cited by 8 publications

References 21 publications

Synthesis of novel quaternary silica hybrid bioactive microspheres

Synthesis of novel quaternary silica hybrid bioactive microspheres

Single subconjunctival injection formulation using sol-gel mesoporous silica as a controlled release system for drop-free post-cataract surgery care

<p>Osteoblast/bone-tissue responses to porous surface of polyetheretherketone–nanoporous lithium-doped magnesium silicate blends’ integration with polyetheretherketone</p>

Contact Info

Product

Resources

About