A New Approach to the Synthesis of Functionalized Bicyclo[3.2.1]octanes

Abstract

The reaction of furfural with secondary amines and isopropyl cyanoacetate leads to the formation of the previously unknown diisopropyl 8-(dialkylamino)-2,4-dicyano-3-(2-furyl)-6- oxobicyclo[3.2.1]octane-2,4-dicarboxylates. The structures of the products were confirmed by NMR and X-ray analysis.