A New Approach to the Synthesis of Poly‐Functionalized Pyrano[2,3‐<i>d</i>]Pyrimidines Derivatives via Microwave‐Assisted Multi‐Component Reactions without Catalyst

Jia, Runhong; Peng, Juhua; Jiang, Bo; Zhang, Junyong; Tu, Shu‐Jiang

doi:10.1002/jhet.2017

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Jia et al . (2014) [70] devised a new and facile method for the synthesis of pyrano[2,3‐ d ] pyrimidine 43 derivatives by microwave‐assisted reactions of 4‐arylmethylene‐2‐phenyloxazol‐5(4 H )‐ones 41 with pyrimidine‐4,6‐diol 42 in ethylene glycol. This procedure is easy to carry out and takes place under mild conditions with a wide range of applicability (Scheme 33).…”

Section: Synthetic Techniques For the Preparation Of Pyrano[23‐d]pyri...mentioning

confidence: 99%

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Rezaeifard,

Bakherad,

Navidpour

et al. 2024

ChemistrySelect

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Due to their extensive applications in pharmaceuticals and natural substances, organic synthesis and heterocyclic compounds have been at the forefront of research for many years. Pyrimidine is one of the heterocyclic compounds that have various derivatives with promising biological and pharmacological properties. This review article covers the synthesis and biological effects of pyrimidine derivatives, such as pyrano[2,3‐d]pyrimidines, pyrido[2,3‐d]pyrimidines, and furo[2,3‐d]pyrimidines. The compounds discussed in this review have a wide range of biological activities. Recent advances in green chemistry have led to the development of eco‐friendly synthetic methods for producing these bioactive heterocycles. This review aims to present various synthetic methods and biological effects of these compounds and provide new opportunities for organic chemists to develop potent nitrogen‐ and oxygen‐containing heterocycles for future applications. The review highlights examples of successful syntheses and applications of pyrimidine derivatives in the fields of antibacterial, antifungal, anticancer, enzyme inhibition, and antiviral research.

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Section: Synthetic Techniques For the Preparation Of Pyrano[23‐d]pyri...mentioning

confidence: 99%

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Rezaeifard,

Bakherad,

Navidpour

et al. 2024

ChemistrySelect

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“…The access of MCRs to design and synthesize the bio‐active compounds with diversity orientation has strongly attracted the synthetic community in both industry and academia . Its application for the synthesis of new heterocycles specifically for the pyrimidine derivatives has been turned as an innovative method during the last decade.…”

Section: Introductionmentioning

confidence: 99%

TiO₂–SiO₂ Catalyzed Eco‐friendly Synthesis and Antioxidant Activity of Benzopyrano[2,3‐d]pyrimidine Derivatives

Kabeer

Reddy

Sreelakshmi

et al. 2017

Journal of Heterocyclic Chem

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A cost‐effective and eco‐friendly synthesis of benzopyrano[2,3‐d]pyrimidine derivatives has been developed via three component one‐pot tandem approach by condensing different salicylaldehydes and secondary amines with malononitrile in the presence of TiO2–SiO2 catalyst at 80°C under solvent‐free conditions. Mild experimental conditions, reusability of the catalyst, and cost effectiveness are the merits of this procedure. Compounds 4g, 4h, and 4i bearing 2‐OMe group on the hydroxyphenyl group linked to the central carbon present in between the two nitrogen atoms of the pyrimidine ring were found to exhibit good antioxidant activity while other compounds have moderate antioxidant activity.

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ChemInform Abstract: A New Approach to the Synthesis of Poly‐Functionalized Pyrano[2,3‐d]pyrimidines Derivatives via Microwave‐Assisted Multi‐Component Reactions Without Catalyst.

Jia¹,

Peng²,

Jiang

et al. 2015

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A New Approach to the Synthesis of Poly‐Functionalized Pyrano[2,3‐d]Pyrimidines Derivatives via Microwave‐Assisted Multi‐Component Reactions without Catalyst

Cited by 4 publications

References 5 publications

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

TiO₂–SiO₂ Catalyzed Eco‐friendly Synthesis and Antioxidant Activity of Benzopyrano[2,3‐d]pyrimidine Derivatives

ChemInform Abstract: A New Approach to the Synthesis of Poly‐Functionalized Pyrano[2,3‐d]pyrimidines Derivatives via Microwave‐Assisted Multi‐Component Reactions Without Catalyst.

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A New Approach to the Synthesis of Poly‐Functionalized Pyrano[2,3‐d]Pyrimidines Derivatives via Microwave‐Assisted Multi‐Component Reactions without Catalyst

Cited by 4 publications

References 5 publications

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

TiO2–SiO2 Catalyzed Eco‐friendly Synthesis and Antioxidant Activity of Benzopyrano[2,3‐d]pyrimidine Derivatives

ChemInform Abstract: A New Approach to the Synthesis of Poly‐Functionalized Pyrano[2,3‐d]pyrimidines Derivatives via Microwave‐Assisted Multi‐Component Reactions Without Catalyst.

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TiO₂–SiO₂ Catalyzed Eco‐friendly Synthesis and Antioxidant Activity of Benzopyrano[2,3‐d]pyrimidine Derivatives