A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha

Wang, Zhan Chang; Lin, Yi Hui; Feng, Dan Qin; Cai, Kai; Lin, Peng; Ye, Chong; Chen, Jun De

doi:10.3390/molecules14010414

Cited by 26 publications

(22 citation statements)

References 25 publications

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“…The mangrove plants possess a number of biological activities such as antibacterial, antioxidant, anticancer, cytotoxic, antiproliferative, insecticidal, antimalarial, antifungal, antifeedant, antidiarrheal, central nervous system depressant, antimitotic, antileukemic and anti-plasmodial activities ( Table 1). Informations of the biological activities of the mangrove plants have been provided by a number of review and research articles (Bandaranayake 2002;Kathiresan et al 2006;Pattanaik et al 2008;Bose and Bose 2008;Jun et al 2008;Singh et al 2009;Manilal et al 2009;Chandrasekaran et al 2009;Vadlapudi and Naidu 2009a;Patra et al 2009a, b;Wang et al 2009). …”

Section: Bioactivity Of Mangrove Plantsmentioning

confidence: 99%

Metabolic diversity and bioactivity screening of mangrove plants: a review

Patra

Thatoi²

2010

Acta Physiol Plant

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Mangrove forests are salt tolerant plants confined to the coastal areas and occupy only 5% of the total forest areas of the world. These are the most hostile environment with fluctuating tidal and saline regime and a limited plant species can survive under such condition. Nevertheless, these plants are most valuable resources and provide economic and ecological benefits to the coastal people. Several mangrove species have been used in traditional medicine or have few applications as insecticide and pesticide. Mangroves are biochemically unique, producing wide array of natural products with unique bioactivity. They possess active metabolites with some novel chemical structures which belong to diverse chemical classes such as alkaloids, phenol, steroids, terpenoids, tannins, etc. The present review examines recent investigations on the biological activities of extracts and phytochemicals identified from mangroves and their associates as antimicrobial, antiviral, antioxidant, anticancer and many other properties like antiproliferative, insecticidal, antimalarial, antifeedant, central nervous system depressant and anti-plasmodial etc. The present article also emphasizes and creates an awareness of potential mangroves and their associates as a source of novel medicines, agrochemicals and source of many biologically active compounds.

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Section: Bioactivity Of Mangrove Plantsmentioning

confidence: 99%

Metabolic diversity and bioactivity screening of mangrove plants: a review

Patra

Thatoi²

2010

Acta Physiol Plant

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“…The leaves and smooth liquid acquired from harmed branches have been utilized as a fish harm in New Caledonia and in Okinawa, the resinous wood including latex, the supposed "Okinawa-Jinko", has likewise been utilized as a substitute for the incense of agalwood [2,3]. The bark and wood of this tree have been utilized as a part of conventional solutions for tooting in Thailand [4,5]. Anjaneyulu and Rao [6,7] revealed countless diterpenoids from n-hexane remove and from ethyl acetic acid derivation solubles of CH 3 OH:CH 2 Cl 2 (1:1) concentrate of the foundations of Indian mangrove plant Excoecaria agallocha L. (family: Euphorbiaceae).…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Flavone of Excoecaria agallocha in Cytotoxicity Studies Using Hela Cells

Rajeswari¹,

Rao²,

Sharma³

et al. 2017

Asian J. Chem.

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In this study, the compound flavone of mangrove plant Excoecaria agallocha was subjected to cytotoxicity studies using Hela cells was produced from ATCC, stock cells was cultured in Dulbecco's Modified Eagle medium (DMEM) supplemented with 10 % inactivated fetal bovine serum (FBS), penicillin (100 IU/mL), streptomycin (100 µg/mL) in an humidified atmosphere of 5 % CO2 at 37 ºC until confluent. The cell was dissociated with trypsin phosphate versene glucose (TPVG) solution (0.2 % trypsin, 0.02% EDTA, 0.05 % glucose in PBS). The viability of the cells are checked and centrifuged. Further 50,000 cells/well was seeded in a 96 well plate and incubated for 24 h. At 37 ºC, 5 % CO2 incubator, it was observed that while concentration increases, the inhibition increases. Finally, the compound showing good activity in Hela cells. Docetaxel was used as standard drug.

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“…Excoecaria agallocha is a well-studied a mangrove plant, with reports on its chemical constituents 16 .…”

Section: Figure 2: Tlc Profile Of the Petroleum Ether Fraction Of Leamentioning

confidence: 99%

Untitled

2014

IJPSR

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Purpose: The focus of the present paper was a preliminary phytochemical and TLC analysis of the various extracts (root, stem and leaf) of the mangrove plant Excoecaria agallocha L. Methods: Phytochemical analysis was carried out using the standard phytochemical assays. TLC analysis of the petroleum ether and chloroform fraction of the leaves was carried out using the solvent system Toluene: Ethyl acetate (in 9:1 ratio) and Toluene: Ethyl acetate: Formic acid (in 5:5:0.2 ratio) for PE and chloroform fractions respectively. Result and conclusion: The results of the preliminary phytochemical screening revealed the presence of various chemical compounds like alkaloids, glycosides, flavonoids, carbohydrates, anthraquinone, tannins, phenols, terpenoids, fixed oil and fats. Organoleptic study revealed the specific nature of the plant parts used in the study. The behavior of the powdered plant parts in presence of various chemicals was studied. TLC analysis of the petroleum ether and chloroform fraction of the leaves of Excoecaria agallocha L. revealed bands indicating the presence of various compounds that could act as potential antimicrobial agents.

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A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha

Cited by 26 publications

References 25 publications

Metabolic diversity and bioactivity screening of mangrove plants: a review

Metabolic diversity and bioactivity screening of mangrove plants: a review

Anticancer Activity of Flavone of Excoecaria agallocha in Cytotoxicity Studies Using Hela Cells

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