A new bilobalide isomer and two cis-coumaroylated flavonol glycosides from Ginkgo biloba leaves

Dong, Hai-li; Lin, Shuo; Wu, Qirui; Su, Ri-xin; Wu, Zhi-li; Dong, Hongyuan; Li, Hui‐Liang; Zhang, Guoqing

doi:10.1016/j.fitote.2020.104516

Cited by 19 publications

(9 citation statements)

References 12 publications

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“…In 2020, Dong et al reported the isolation of a new sesquiterpene with two lactone ring groups from G. biloba leaves, found to be a BB isomer (12). 88 Compared with 11, this isomer has one less lactone ring and one more exposed hydroxyl group (Fig. 1, Table S1…”

Section: Terpenoidsmentioning

confidence: 99%

“…299 Both BB (11) and its newly identied isomer showed no inhibitory effect against PAF. 88 The structure-activity relationship (SAR) between ginkgolides and PAFR has been well studied through the synthesis of putative ginkgolide derivatives and evaluation of their activity (Fig. 12).…”

Section: Blood Circulation Disorder Regulationmentioning

confidence: 99%

“…Only two glycosides— 83 and 84 —are of the E-alkene type. 88 The feruloyl flavonol glycoside identified was 85 . 57 The caffeoyl flavonol glycoside identified is 86 .…”

Section: Structuresmentioning

confidence: 99%

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Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.

Liu

Gao

et al. 2022

Nat. Prod. Rep.

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Section: Terpenoidsmentioning

confidence: 99%

Section: Blood Circulation Disorder Regulationmentioning

confidence: 99%

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Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.

Liu

Gao

et al. 2022

Nat. Prod. Rep.

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“…Ten diterpenoid lactones have been discovered, known as ginkgolides Q, P, N, M, L, K, J, C, B, and A. Until recently, bilobalide was thought to be the only sesquiterpene lactone in G. biloba, but Dong et al announced a new bilobalide isomer in 2020 [28]. G. biloba also contains nor-terpenoids, including three nor-sesquiterpenoids discovered by Shu et al in G. biloba L. [29].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

Noor-E-Tabassum

Das

Lami

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Ginkgo biloba is an ancient plant species that is thought to provide a variety of health benefits to living organisms and contains plenty of bioactive components, making it a chemically diversified plant. G. biloba has been shown to have a variety of medicinal and pharmacological properties, including anticancer, antidementia, antidiabetic, antiobesity, antilipidemic, antimicrobial, antioxidant, antilipid peroxidation, antiplatelet, anti-inflammatory, hepatoprotective, antidepressant, antiaging, immunomodulatory, antihypertensive, and neuroprotective effects and is frequently used to treat neurological, cardiovascular, and respiratory diseases, such as tardive dyskinesia. Therefore, this review described the therapeutic applications of G. biloba. In addition to describing the therapeutic potential, this review also evaluates the chemical constituents, toxicity, adverse effect, synergistic effect, and the clinical studies of this plant which have been utilized for therapeutic benefits but have demonstrated other consequences. The capacity of G. biloba components to act as free radical scavengers is critical, and combining its extract with other plant extracts has been shown to synergistically boost antioxidant properties. G. biloba used long-term or at high doses that resulted in some adverse effects. Severe drug interactions have also been reported in both animals and humans when combined with other medications. The available data established from both preclinical and clinical studies confirm the potential of G. biloba plant extract in various diseases. Besides, the safety and efficacy of G. biloba continue to require verification through additional experimentation to guide medicinal use.

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“…High-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) have been the most frequently employed methods for the separation of flavonoids from samples. 12–15 Compared with HPLC, CE analysis has some advantages, such as high separation efficiency, short analysis time and low sample consumption, which makes CE a suitable method for the separation of flavonoids. Common detection modes for CE are ultraviolet (UV), mass spectrum (MS), laser-induced fluorescence (LIF) and amperometric detection (AD).…”

Section: Introductionmentioning

confidence: 99%

Fluorescence enhancement of flavonoids and its application in ingredient determination for some traditional Chinese medicines by CE-LIF

et al. 2023

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A new bilobalide isomer and two cis-coumaroylated flavonol glycosides from Ginkgo biloba leaves

Cited by 19 publications

References 12 publications

Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.

Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

Fluorescence enhancement of flavonoids and its application in ingredient determination for some traditional Chinese medicines by CE-LIF

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