A New Blood Pump for Cardiopulmonary Bypass: The HiFlow Centrifugal Pump

Göbel, Carolin; Eilers, Rolf; Reul, H.; Schwindke, P.; Jörger, Manfred; Rau, G.

doi:10.1111/j.1525-1594.1997.tb03754.x

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…1). Thirteen studies were non‐RCTs (19–31) of which three were retrospective observational designs (28–30). Four manuscripts were excluded for study methodology where RP and CP groups received different treatment regimens beyond the main arterial pump and were deemed incomparable (32–35).…”

Section: Resultsmentioning

confidence: 99%

Centrifugal Pump and Roller Pump in Adult Cardiac Surgery: A Meta‐Analysis of Randomized Controlled Trials

et al. 2012

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Centrifugal pump (CP) and roller pump (RP) designs are the dominant main arterial pumps used in cardiopulmonary bypass (CPB). Trials reporting clinical outcome measures comparing CP and RP are controversial. Therefore, a meta‐analysis was undertaken to evaluate clinical variables from randomized controlled trials (RCTs). Keyword searches were performed on Medline (1966–2011), EmBase (1980–2011), and CINAHL (1981–2011) for studies comparing RP and CP as the main arterial pump in adult CPB. Pooled fixed‐effects estimates for dichotomous and continuous data were calculated as an odds ratio and weighted‐mean difference, respectively. The P value was utilized to assess statistical significance (P < 0.05) between CP and RP groups. Eighteen RCTs met inclusion criteria, which represented 1868 patients (CP = 961, RP = 907). The prevailing operation was isolated coronary artery bypass graft surgery (CP = 88%, RP = 87%). Fixed‐effects pooled estimates were performed for end‐of‐CPB (ECP) and postoperative day one (PDO) for platelet count (ECP: P = 0.51, PDO: P = 0.16), plasma free hemoglobin (ECP: P = 0.36, PDO: P = 0.24), white blood cell count (ECP: P = 0.21, PDO: P = 0.66), and hematocrit (ECP: P = 0.06, PDO: P = 0.51). No difference was demonstrated for postoperative blood loss (P = 0.65) or red blood cell transfusion (P = 0.71). Intensive care unit length of stay (P = 0.30), hospital length of stay (P = 0.33), and mortality (P = 0.91) were similar between the CP and RP groups. Neurologic outcomes were not amenable to pooled analysis; nevertheless, the results were inconclusive. There was no reported pump‐related malfunction or mishap. The meta‐analysis of RCTs comparing CP and RP in adult cardiac surgery suggests no significant difference for hematological variables, postoperative blood loss, transfusions, neurological outcomes, or mortality.

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Section: Resultsmentioning

confidence: 99%

Centrifugal Pump and Roller Pump in Adult Cardiac Surgery: A Meta‐Analysis of Randomized Controlled Trials

et al. 2012

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“…В большинстве работ [17][18][19][20][21][22] где Hb -общий гемоглобин в начальный момент времени (мг/л); pHb -увеличение свободного ге моглобина плазмы (г/л) в течение интервала време ни выборки; V -объем контура (л); Q -расход кро ви (л/мин); Ht -гематокрит (%); T -время работы насоса (мин). Типовая схема гидравлического стенда для гемо лизных испытаний представляет собой замкнутый контур, состоящий из венозного резервуара, систе мы трубок и гидродинамического сопротивления (ГДС), предназначенного для установки перепада давления при заданном расходе насоса.…”

Section: материалы и методика испытанийunclassified

Hemolysis research of implantable axial flow pump for two -step heart transplantation in children

Дмитриева

Бучнев

Drobyshev

et al. 2017

RJTAO

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Introduction.One of the main indicators characterizing mechanical circulatory support devices (artificial valve, implantable pumps, etc.) is trauma of blood cells. Therefore, while developing new pumps, one of the key studies in vitro is to evaluate blood hemolysis. For an objective hemolysis analysis of pump it is required to create a standardized methodology of hemolysis studies. The object of the study in this paper is implantable axial pump DON for two-step heart transplantation in children.The aimof study is to develop a standardized methodology of hemolysis studies of blood pumps and to conduct research of pediatric axial pump DON.Materials and methods.To conduct hemolysis research we created a mock circulatory system consisting of a reservoir placed in water bath maintaining a constant working fluid (blood) temperature, hydrodynamic resistance, connecting tubes, ports for blood sampling and pressure and flow measurement systems, and research pump. Test method is to estimate levels of free hemoglobin pHb obtained by blood samples during pump working in operating mode (for pediatric pump: blood flow 2.5 l/min, pressure difference 80 mmHg). Using the data obtained the standardized indices of hemolysis NIH and MIH are calculated based on pHb values, hematocrit, total hemoglobin, blood flow and working pump time.Results.We developed and realized a standardized methodology of hemolysis research by which we evaluated hemolysis of pediatric axial pump. The results of hemolysis tests allowed us to optimize the design of DON. Obtained values of hemolysis of the latest version of pediatric pump DON-3 have shown that they do conform to the requirements of minimum blood injury and it allows us to proceed to the next step of pediatric pump research – animal experiments.Conclusion.Developed methods and evaluation tools of hemolysis allow us to provide objective information on one of the most important indicators of developing implantable pediatric axial pump and they could be recommended for hemolysis research of others pumps.

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“…T -интервал времени отбора проб (мин). NIH был рассчитан по формуле, применяемой при проведении аналогичных исследований [13][14][15][16][17][18]:…”

Section: Introductionunclassified

Влияние Насоса Вспомогательного Кровообращения Дискового Типа На Гемолитические, Ионные И Кислотно-Щелочные Показатели Крови in Vitro И in Vivo Экспериментах

Головина¹

2023

Влияние Насоса Вспомогательного Кровообращения Дискового Типа На Гемолитические, Ионные И Кислотно-Щелочные Показатели Крови In

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A New Blood Pump for Cardiopulmonary Bypass: The HiFlow Centrifugal Pump

Cited by 9 publications

References 4 publications

Centrifugal Pump and Roller Pump in Adult Cardiac Surgery: A Meta‐Analysis of Randomized Controlled Trials

Centrifugal Pump and Roller Pump in Adult Cardiac Surgery: A Meta‐Analysis of Randomized Controlled Trials

Hemolysis research of implantable axial flow pump for two -step heart transplantation in children

Влияние Насоса Вспомогательного Кровообращения Дискового Типа На Гемолитические, Ионные И Кислотно-Щелочные Показатели Крови in Vitro И in Vivo Экспериментах

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