A New Bone Substitute Developed from 3D-Prints of Polylactide (PLA) Loaded with Collagen I: An In Vitro Study

Ritz, Ulrike; Gerke, Rebekka; Götz, Hermann; Stein, Stefan; Rommens, Pol Maria

doi:10.3390/ijms18122569

Cited by 61 publications

(44 citation statements)

References 58 publications

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“…3D printing is a novel procedure to create 3D porous scaffolds used for bone tissue engineering (Roseti et al ). Solid discs as well as porous cage‐like 3D structures made of PLA coated or filled with collagen were tested for biocompatibility and endotoxin production, respectively (Ritz et al ). This study confirmed the PLA biocompatibility as well as the endotoxin contaminations levels that were below the FDA limit.…”

Section: Pla Biomedical Applicationsmentioning

confidence: 99%

Polylactic acid: synthesis and biomedical applications

2019

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Social and economic development has driven considerable scientific and engineering efforts on the discovery, development and utilization of polymers. Polylactic acid (PLA) is one of the most promising biopolymers as it can be produced from nontoxic renewable feedstock. PLA has emerged as an important polymeric material for biomedical applications on account of its properties such as biocompatibility, biodegradability, mechanical strength and process ability. Lactic acid (LA) can be obtained by fermentation of sugars derived from renewable resources such as corn and sugarcane. PLA is thus an eco‐friendly nontoxic polymer with features that permit use in the human body. Although PLA has a wide spectrum of applications, there are certain limitations such as slow degradation rate, hydrophobicity and low impact toughness associated with its use. Blending PLA with other polymers offers convenient options to improve associated properties or to generate novel PLA polymers/blends for target applications. A variety of PLA blends have been explored for various biomedical applications such as drug delivery, implants, sutures and tissue engineering. PLA and their copolymers are becoming widely used in tissue engineering for function restoration of impaired tissues due to their excellent biocompatibility and mechanical properties. The relationship between PLA material properties, manufacturing processes and development of products with desirable characteristics is described in this article. LA production, PLA synthesis and their applications in the biomedical field are also discussed.

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Section: Pla Biomedical Applicationsmentioning

confidence: 99%

Polylactic acid: synthesis and biomedical applications

2019

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“…3D scaffolds with a porosity structure is suitable for loading ions, nanoparticles, and biomolecules to achieve multifunctional application. 130 In Correia et al study, 131 the tricalcium phosphate (TCP)/sodium alginate (SA) scaffolds were produced by 3DP. Subsequently, AgNPs were incorporated into scaffolds through two different methods, direct incorporation and physical adsorption.…”

Section: Plasma Electrolytic Oxidation (Peo)mentioning

confidence: 99%

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Qing

Cheng

et al. 2018

IJN

764

362

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Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.

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“…Cells can be incorporated as demonstrated by Lee et al, who used collagen as bioink supplemented with pre-osteoblasts [20]. Among others, we printed PLA and collagen to induce tissue regeneration in bone defects [21]. Martin et al printed PLA and functionalized the scaffolds with collagen, minocycline and citrate hydroxyapatite nanoparticles [22].…”

Section: Introductionmentioning

confidence: 99%

Biofabrication of SDF-1 Functionalized 3D-Printed Cell-Free Scaffolds for Bone Tissue Regeneration

Lauer

Wolf

Mehler

et al. 2020

IJMS

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Large segmental bone defects occurring after trauma, bone tumors, infections or revision surgeries are a challenge for surgeons. The aim of our study was to develop a new biomaterial utilizing simple and cheap 3D-printing techniques. A porous polylactide (PLA) cylinder was printed and functionalized with stromal-derived factor 1 (SDF-1) or bone morphogenetic protein 7 (BMP-7) immobilized in collagen type I. Biomechanical testing proved biomechanical stability and the scaffolds were implanted into a 6 mm critical size defect in rat femur. Bone growth was observed via x-ray and after 8 weeks, bone regeneration was analyzed with µCT and histological staining methods. Development of non-unions was detected in the control group with no implant. Implantation of PLA cylinder alone resulted in a slight but not significant osteoconductive effect, which was more pronounced in the group where the PLA cylinder was loaded with collagen type I. Addition of SDF-1 resulted in an osteoinductive effect, with stronger new bone formation. BMP-7 treatment showed the most distinct effect on bone regeneration. However, histological analyses revealed that newly formed bone in the BMP-7 group displayed a holey structure. Our results confirm the osteoinductive character of this 3D-biofabricated cell-free new biomaterial and raise new options for its application in bone tissue regeneration.

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A New Bone Substitute Developed from 3D-Prints of Polylactide (PLA) Loaded with Collagen I: An In Vitro Study

Cited by 61 publications

References 58 publications

Polylactic acid: synthesis and biomedical applications

Polylactic acid: synthesis and biomedical applications

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Biofabrication of SDF-1 Functionalized 3D-Printed Cell-Free Scaffolds for Bone Tissue Regeneration

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