A new causal centrality measure reveals the prominent role of subcortical structures in the causal architecture of the extended default mode network

Zarghami, Tahereh S.

doi:10.1007/s00429-023-02697-w

Cited by 1 publication

(1 citation statement)

References 188 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 108 This might be especially relevant, taking into account the role of the amygdala as one of various subcortical regions with a causal inhibitory role in the activity of the default mode network. 109 The left amygdala, as well as the hippocampus, presents volume reductions in Alzheimer’s disease, 110 which are associated with the carriage of APOE-ε4 alleles. 111 Furthermore, there is an inverse relationship between tau brain accumulation and left amygdala shape.…”

Section: Discussionmentioning

confidence: 99%

The subcortical default mode network and Alzheimer’s disease: a systematic review and meta-analysis

Seoane,

van den Heuvel,

Acebes

et al. 2024

Brain Communications

View full text Add to dashboard Cite

The default mode network is a central cortical brain network suggested to play a major role in several disorders, and to be particularly vulnerable to the neuropathological hallmarks of Alzheimer’s disease. Subcortical involvement in the default mode network and its alteration in Alzheimer’s disease remains largely unknown. We performed a systematic review, meta-analysis, and empirical validation of the subcortical default mode network in healthy adults, combined with a systematic review, meta-analysis, and network analysis of the involvement of subcortical default mode areas in Alzheimer’s disease. Our results show that, besides the well-known cortical default mode network brain regions, the default mode network consistently includes subcortical regions, namely the thalamus, lobule and vermis IX and right Crus I/II of the cerebellum, and the amygdala. Network analysis also suggests the involvement of the caudate nucleus. In Alzheimer’s disease, we observed a left-lateralized cluster of decrease in functional connectivity which covered the medial temporal lobe and amygdala and showed overlap with the default mode network in a portion covering parts of the left anterior hippocampus and left amygdala. We also found an increase in functional connectivity in the right anterior insula. These results confirm the consistency of subcortical contributions to the default mode network in healthy adults and highlight the relevance of the subcortical default mode network alteration in Alzheimer’s disease.

show abstract