A new chiral electrochemical sensor for the enantioselective recognition of naproxen enantiomers using l-cysteine self-assembled over gold nanoparticles on a gold electrode

Abstract

A chiral electrochemical sensor for the analysis of chiral compounds enantiomeric composition is reported. The method is based on the difference in the interaction of the naproxen (Nap) enantiomers with the chiral modified electrode surface. A chiral surface was synthesized on a gold electrode modified with gold nanoparticles and L-cysteine self-assembled monolayers (SAMs). Scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to study the enantioselective interaction between the chiral surface and Nap enantiomers. The results showed that the modified electrode can be better stereoselective for S-Nap than for R-Nap. The examination of the characteristics of the chiral interface, including the response time, the effect of enantiomers concentration, and the stability, were investigated. Then the chiral selective interface was used to determine the Nap enantiomers mixtures by measuring the change in the peak current in different compositions from them. The results suggested that the proposed chiral biosensor with high sensitivity and selectivity can be used to the recognition of Nap enantiomers.

A simple approach to prepare fluorescent molecularly imprinted nanoparticles

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“…The detection of chiral molecules is of great importance in the field of both biology and chemistry because the enantiomers may exhibit completely different activities [ 76 , 77 ]. Chirality refers to structures with broken mirror symmetry such as the enantiomers, which universally exists in chemical molecules [ 78 ].…”

Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products

“…Alternatively, Pt electrodes were suggested for anodic oxidation of naproxen [19]; the high background current with limited sensitivity and reproducibility due to contamination by the fouling products and impurities was reported [20]. Recently, other electrode materials were applied including boron-doped diamond [21, 22], gold electrode [23], glassy carbon [24], graphite electrode [25, 26], multiwall carbon nanotube-modified glassy carbon electrode (MWCNTs/GCE) [27, 28], and carbon paste electrodes modified with different nanomaterials [29–31] were reported.…”