A new composite skin prosthesis

Tavis, Michael J.; Thornton, James W.; Bartlett, Robert H.; Roth, Jeffrey C.; Woodroof, E. Aubrey

doi:10.1016/0305-4179(80)90038-8

Cited by 77 publications

(23 citation statements)

References 43 publications

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“…A related product is Biobrane Ò (Smith & Nephew), which consists of a silicone sheet with a partially embedded nylon fabric embedded on the surface. 32 This nylon fabric is then coated with porcine dermal collagen. Blood and sera from the wound form a clot within the nylon fabric attaching the dressing to the wound, while the collagen promotes fibroblast growth and maintains a hydrated environment.…”

Section: Use Of Biologic Scaffolds In Wound Repairmentioning

confidence: 99%

The Use of Biologic Scaffolds in the Treatment of Chronic Nonhealing Wounds

Turner

Badylak

2015

Advances in Wound Care

137

106

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Injuries to the skin as a result of illness or injury, particularly chronic nonhealing wounds, present a major healthcare problem. Traditional wound care approaches attempt to control the underlying causes, such as infection and ischemia, while the application of wound dressings aims to modify a poorly healing wound environment into a microenvironment more closely resembling an acute wound allowing the body to heal the wound naturally. Regenerative medicine approaches, such as the use of biologic scaffold materials comprising an intact extracellular matrix (ECM) or individual components of the ECM, are providing new therapeutic options that focus upon the provision of biochemical cues that alter the wound microenvironment to facilitate rapid restoration of normal skin architecture. The incidence of chronic nonhealing wounds continues to increase. For example, between 15% and 20% of diabetics are likely to develop chronic, nonhealing foot wounds creating an increasing burden on healthcare systems worldwide. Developing a thorough understanding of wound microenvironment and the mechanisms by which biologic scaffolds work has the potential to markedly improve outcomes in the clinical translation for the treatment of chronic wounds.

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Section: Use Of Biologic Scaffolds In Wound Repairmentioning

confidence: 99%

The Use of Biologic Scaffolds in the Treatment of Chronic Nonhealing Wounds

Turner

Badylak

2015

Advances in Wound Care

137

106

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“…Missing transparency, the pain induction, traumatising of the wound ground and the incorporation of PU fragments are unfavourable during removal of the material. Biobrane ® [70], a bi-layer made of a nylon net with a polydimethylsiloxane surface layer, appeared more stable and therefore better suitable. However, bacterial wound infection was reported with its application [71].…”

Section: Wound Dressingsmentioning

confidence: 99%

Biodegradable Films in Trauma and Orthopedic Surgery

Jürgens

Schulz²,

Porté³

et al. 2006

Eur J Trauma

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Resorbable materials have gained a considerable position in the daily routine of all surgical disciplines. Natural products like catgut and collagen have been used historically. Since the development of synthetical macromolecules more than 40 years ago, the range of indications for the use of such materials has widened significantly in our daily routine. Suture materials, mesh, tissue pads, clips, screws and anchors are in use. More recent developments in the field of orthopedic and trauma surgery include screw-plate systems, wound dressing materials and films for the prevention of adhesions and ossifications. This appears to be the beginning of an era of new materials as these implants not only fulfil a temporary biomechanical role but in theory also can release a controlled amount of biologically active substances at a set timeframe. Also they are potential carriers for transplants on a cellular level. This aspect will be of importance in the orthopedic field, where resorbable films only play a minor role so far.At the moment there are six resorbable or biodegradable films or foils on the market that are used or can be used in the field of orthopedic and trauma surgery.These are foils and films made of following materials: carboxy-methyl-cellulose and hyaloronic acid (Seprafilm®), oxydized regenerated cellulose (Interceed®), polydioxanon (PDS®) and copolymers of lactid und caprolacton (Topkin®, Oprafol®, Mesofol®).Main indications for their use are wound dressing, especially after split skin graft and thermal wounds, prophylaxis of adhesions and prevention of the formation of synostoses and heterotopic ossifications. The results of clinical trials are promising and the increasing number of publications in the last 5 years in this field is an expression of increasing demand of these materials. However, it could also be an expression of the growing interest in drug delivery techniques as well as in tissue engineering which are possible with these materials.

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“…Storage is at room temperature. Evaporative water loss is slightly higher than from uninjured skin (Tavis et al, 1980).…”

Section: Synthetic Skin Substitutesmentioning

confidence: 99%

“…collagen, a very effective skin substitute can be produced. Biobrane (Tavis, Thornton, Bartlett, Roth & Woodroof, 1980) consists of a custom-knitted nylon fabric bonded to an ultrathin silicone rubber membrane. The layer to be placed on the wound consists of porcine collagenous peptides.…”

Section: Synthetic Skin Substitutesmentioning

confidence: 99%