A new cyclopeptide from Dianthus caryophyllus

Li, Fēi; Zhang, Feng Mei; Yang, Yu‐Rong; Yang, Xue; Cao, Qiu E.; Ding, Zhong Tao

doi:10.1016/j.cclet.2007.12.010

Cited by 4 publications

(5 citation statements)

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“…Thus, we would predict the presence of these CPs in D. caryophyllus. Incidentally, the authors are aware of only one report of CPs in D. caryophyllus, which provides evidence for the presence of caryophllusin [sic] A [cyclo-(GPYFT)] and delavayin B [cyclo-(GSIFFA)] (Morita et al, 1997;Li et al, 2008).…”

Section: Detection Of Segetalins J and K In S Vaccaria Seedsmentioning

confidence: 99%

The biosynthesis of Caryophyllaceae‐like cyclic peptides in Saponaria vaccaria L. from DNA‐encoded precursors

et al. 2011

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SUMMARYCyclic peptides (CPs) are produced in a very wide range of taxa. Their biosynthesis generally involves either non-ribosomal peptide synthases or ribosome-dependent production of precursor peptides. Plants within the Caryophyllaceae and certain other families produce CPs which generally consist of 5-9 proteinogenic amino acids. The biological roles for these CPs in the plant are not very clear, but many of them have activity in mammalian systems. There is currently very little known about the biosynthesis of CPs in the Caryophyllaceae. A collection of expressed sequence tags from developing seeds of Saponaria vaccaria was investigated for information about CP biosynthesis. This revealed genes that appeared to encode CP precursors which are subsequently cyclized to mature CPs. This was tested and confirmed by the expression of a cDNA encoding a putative precursor of the CP segetalin A in transformed S. vaccaria roots. Similarly, extracts of developing S. vaccaria seeds were shown to catalyze the production of segetalin A from the same putative (synthetic) precursor. Moreover, the presence in S. vaccaria seeds of two segetalins, J [cyclo(FGTHGLPAP)] and K [cyclo(GRVKA)], which was predicted by sequence analysis, was confirmed by liquid chromatography/mass spectrometry. Sequence analysis also predicts the presence of similar CP precursor genes in Dianthus caryophyllus and Citrus spp. The data support the ribosome-dependent biosynthesis of Caryophyllaceae-like CPs in the Caryophyllaceae and Rutaceae.

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Section: Detection Of Segetalins J and K In S Vaccaria Seedsmentioning

confidence: 99%

The biosynthesis of Caryophyllaceae‐like cyclic peptides in Saponaria vaccaria L. from DNA‐encoded precursors

et al. 2011

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“…We report the isolation and structure determination of five undescribed orbitides, dianthiamides A–E, from the whole plants of D. chinensis . The previously reported orbitides isolated from the genus Dianthus tend to have five to six amino acid residues [ 4 , 5 , 6 , 7 , 8 , 9 ]. All orbitides in this study, however, are characteristic of the presence of six to eight amino acids, while they are featured by containing at least one proline residue.…”

Section: Discussionmentioning

confidence: 99%

“…The whole plant of D. chinensis is commonly used as a traditional medicine in Korea for treating diuretic, carcinoma, urethritis, and carbuncles [ 1 , 2 , 3 , 4 , 5 , 6 ]. Previous investigation on the phytochemical constituents of the genus Dianthus led to the isolation of cyclopeptides [ 4 , 5 , 6 , 7 , 8 , 9 ], dianthramides [ 5 , 10 , 11 ], triterpenoidal saponins [ 1 , 2 , 3 , 12 , 13 ], anthocyanins [ 14 ], and pyran-type glycosides [ 15 ]. Orbitides, formerly known as Caryophyllaceae-type cyclic peptides, are N-to-C cyclized plant peptides lacking disulfide bonds, which possess 5 to 12 amino acid residues.…”

Section: Introductionmentioning

confidence: 99%

Dianthiamides A–E, Proline-Containing Orbitides from Dianthus chinensis

et al. 2021

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Orbitides are plant-derived small cyclic peptides with a wide range of biological activities. Phytochemical investigation of the whole plants of Dianthus chinensis was performed with the aim to discover new bioactive orbitides. Five undescribed proline-containing orbitides, dianthiamides A–E (1–5), were isolated from a methanolic extract of Dianthus chinensis. Their structures were elucidated by extensive analysis of 1D and 2D NMR and HRESI–TOF–MS as well as ESI–MS/MS fragmentation data. The absolute configuration of the amino acid residues of compounds 1–5 was determined by Marfey’s method. All compounds were tested for their cytotoxic activity, and dianthiamide A (1) exhibited weak activity against A549 cell line with IC50 value of 47.9 μM.

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“…Reference [1] compared the energy detection,the auto-correlation detection,adaptive line enhancement and DFT analysis method, meanwhile subsequent literature gave the corresponding simulation results. Reference [2] resampled the data in the time domain and selected different window function for interval Fourier transform ,at last, using corresponding interpolation function to obtain a clear line.…”

Section: Introductionmentioning

confidence: 99%

Research of Vector Hydrophone Adaptive Signal Processing

Cheng

Zhang

2013

AMM

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As a useful tool for line spectrum detection in underwater signal ,ALE has been used wildly. But there are still some problems to influence the effect of ALE. This paper gives three problems on ALE and analyses these.Then by the characteristics of vector hydrophone and a improved variable step size LMS,this paper constructs a cascade double input with variable step size based on vector hydrophone line spectrum enhancer . This algorithm restrains the noise of main channel twice ,meanwhile controls the noise in reference channel , so as to improve signal to noise ratio better. At the same time ,because of adopting the improved variable step size LMS, the steady-state error is reduced. From the results of simulation and experiment, the method presented in this paper can have a better effect of line spectrum enhancement.

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A new cyclopeptide from Dianthus caryophyllus

Cited by 4 publications

References 4 publications

The biosynthesis of Caryophyllaceae‐like cyclic peptides in Saponaria vaccaria L. from DNA‐encoded precursors

The biosynthesis of Caryophyllaceae‐like cyclic peptides in Saponaria vaccaria L. from DNA‐encoded precursors

Dianthiamides A–E, Proline-Containing Orbitides from Dianthus chinensis

Research of Vector Hydrophone Adaptive Signal Processing

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