A new diphenyl ether from <i>Parmotrema indicum</i> Hale growing in Vietnam

Do, Thanh-Hung; Trung, Nguyễn Thành; Dao, Thi-Bich-Ngoc; Vo, Huu-Canh; Huynh, Bui-Linh-Chi; Nguyen, Thi-Anh-Tuyet; Mai, Dinh-Tri; Vo, Thi-Phi-Giao; Sichaem, Jirapast; Nguyen, Ngoc-Hong; Duong, Thuc‐Huy

doi:10.1080/14786419.2021.1907748

Cited by 3 publications

(1 citation statement)

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“…This indicated the important role of the depsidone scaffold in α ‐glucosidase inhibition. The results were consistent with previously reported depsidones from Parmotrema lichens [8–11,15–16] . Noteworthy, the difference in α ‐glucosidase inhibitory activity between 1 and 2 suggested that the phenolic (D‐ring) and oxotetrahydrofuranyl moieties in 1 was possibly decrease in inhibitory activity against α ‐glucosidase.…”

Section: Resultssupporting

confidence: 92%

Two New α‐Glucosidase Inhibitory Depsidones from the Lichen Parmotrema cristiferum (Taylor) Hale

Duong

et al. 2023

Chemistry & Biodiversity

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A bioactivity-guided investigation of the lichen Parmotrema cristiferum (Taylor) Hale (Parmeliaceae) led to the isolation of two new depsidones, cristifones A and B (1 and 2). The structures of the isolated compounds were identified by spectroscopic methods and comparison with the literature data. Compound 1 showed the initial combined structures of depsidone and depside cores. The two isolated compounds were then evaluated for αglucosidase inhibition. Compounds 1 and 2 were confirmed as potent, with IC 50 values of 21.5 and 18.4 μM, respectively. Compound 2 was a non-competitive inhibitor against α-glucosidase, as indicated by the intersect in the second quadrant of each respective plot.

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Section: Resultssupporting

confidence: 92%