The 23rd International Electronic Conference on Synthetic Organic Chemistry 2019
DOI: 10.3390/ecsoc-23-06501
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A New Efficient Route to 2-Alkylsemicarbazides

Abstract: Synthesis of hardly available 2-alkylsemicarbazides and their hydrochlorides from semicarbazide hydrochloride has been developed. This general and efficient protocol is based on preparation of acetone semicarbazone, its N2-alkylation in the presence of sodium hydride, and hydrolysis under mild conditions.

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