A new era in cervical cancer prevention

Roeske, Lara

doi:10.31128/ajgp-01-18-4464

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…Approximately 90% of the world’s cervical cancer occurs in countries without effective HPV screening and vaccination [ 22 ]. However, formal screening programs have benefited many countries, and cancer prevalence and mortality have decreased by more than half in the past 30 years [ 22 , 23 ]. Therefore, organised cervical cytology, pre-invasive disease treatment and vaccination are key measures to reduce the incidence of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection

et al. 2022

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Background The infection rate of human papillomavirus (HPV) is high in the coastal regions of China. However, the infection rate among high-risk genotypes of women in Putian City is unknown. Therefore, this study aimed to analyse the epidemiology of high-risk HPV infection among women in Putian and provide a reference for the diagnosis, treatment and vaccination of cervical cancer in this region. Methods The data used were obtained from the Chinese government’s public health program (“Cervical and Breast Cancer Screening Project”). A total of 40,693 female cervical cell exfoliation samples screened for high-risk HPV at the Affiliated Hospital of Putian University from July 2020 to December 2021 were enrolled. DNA was extracted using a fully automatic extractor. Then, 14 high-risk genotypes of HPV were detected by polymerase chain reaction. The characteristics of HPV infection, distribution of high-risk genotypes, infection types and thinprep cytologic test (TCT) classification at different age groups were analysed. Results Among the 40,693 samples, 3899 were infected with HPV, with an infection rate of 9.6%. Accordingly, HPV infection rates gradually increased with age, and statistically significant differences were observed among age groups (χ2 = 74.03, P < 0.01). The infection rates of high-risk HPV52, HPV58 and HPV16 were in the top three and increased with age. Single infection was dominant (84.7%), followed by double infections (12.7%). The cervical cytology of 3899 HPV-positive people can be classified into negative for intraepithelial lesion and malignancy (NILM, 88.0%), atypical squamous cells of undetermined significance (ASC-US, 6.6%), atypical squamous cells—cannot exclude high-grade squamous intraepithelial lesion (ASC-H, 1.4%), low-grade squamous intraepithelial lesion (LSIL, 3.2%) and high-grade squamous intraepithelial lesion (HSIL, 0.8%). HPV16 infection rate increased with increasing severity of cervical cytology (χ2trend = 43.64, P < 0.01), whereas the infection rates of HPV52 (χ2trend = 13.89, P < 0.01) and HPV58 (χ2trend = 13.50, P < 0.01) showed opposite trends. Conclusion The infection rate of female HPV high-risk screening in this region was 9.6% and mainly involved single infections. In addition, HPV16, HPV52 and HPV58 were closely related to the severity of cervical cytology. Effective screening, vaccination and education are needed. The 9-valent vaccine will be effective in reducing cervical pre-invasive disease. It would also be reasonable to state that the rising trend in HPV infection and high grade cytology with age emphasises the need to target older women with screening. Vaccination of younger women (aged ≤ 25) will lay the foundation for better cancer outcomes in the future.

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Section: Introductionmentioning

confidence: 99%

Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection

et al. 2022

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“…Correct implementation of the renewed NCSP is required for the success of the program. [4][5][6] Improving consumer and health professional confidence and participation in the renewed program is a key element in the elimination of cervical cancer in Australia. 7 It is imperative that health professionals delivering cervical screening are familiar with and confident in following the current evidence-based guidelines, which will in turn ensure that women receive appropriate screening and follow-up.…”

Section: Methodsmentioning

confidence: 99%

Renewal of the National Cervical Screening Program: health professionals’ knowledge about screening of specific populations in NSW, Australia

Sweeney¹,

Cheng²,

Botfield³

et al. 2022

Public Health Res Pract

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We surveyed health professionals conducting cervical screening in NSW, Australia, to better understand their knowledge of the renewed National Cervical Screening Program • Our study identified gaps in knowledge regarding screening for specific populations of women, including immunedeficient women, women who have had a hysterectomy, and those who have an indication for sample self-collection • Ongoing support is needed for health professionals to ensure translation of guidelines into practice

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“…Approximately 90% of the world's cervical cancer occurs in countries without effective HPV screening and vaccination [12]. However, formal screening programs have bene ted many countries, and cancer prevalence and mortality have more than halved in the past 30 years [12,13]. Therefore, HPV screening and vaccination are crucial measures to prevent cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological study of HPV infection in 40693 women in Putian: a population study based on screening for high-risk HPV infection

Chen

Lin

Zheng

et al. 2022

Preprint

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Background: The infection rate of human papillomavirus (HPV) is high in coastal regions of China. However, the infection of high-risk genotypes of women in Putian City is unknown. Therefore, this study aimed to analyse the epidemiology of high-risk HPV infection among women in Putian and provide a reference for the diagnosis, treatment, and vaccination of cervical cancer in this region.Methods: A total of 40693 female cervical cell exfoliation samples screened for high-risk HPV at the Affiliated Hospital of Putian University from July 2020 to December 2021 were selected. DNA was extracted using a fully automatic extractor. Then, 14 high-risk genotypes of HPV were detected by polymerase chain reaction. The characteristics of HPV infection, distribution of high-risk genotypes, infection types, and TCT classification in different age groups were analysed.Results: Of the 40693 samples, 3899 were infected with HPV, with an infection rate of 9.6%. Accordingly, HPV infection rates gradually increased with age, with statistically significant differences among age groups (χ2=74.03, P<0.01). The infection rates of high-risk HPV52, HPV58, and HPV16 ranked in the top three and increased with age. Single infection was dominant (84.7%), followed by double infections (12.7%). In addition, the cervical cytological classification of 3899 HPV-positive people was as follows: NILM (88.0%), ASC-US (6.6%), ASC-H (1.4%), LSIL (3.2%), and HSIL (0.8%). The study found that the HPV16 infection rate increased with increasing severity of cervical cytology (χ2trend=43.64, P<0.01), while the infection rates of HPV52 (χ2trend=13.89, P<0.01) and HPV58 (χ2trend=13.50, P<0.01) showed opposite trends.Conclusions: The infection rate of female HPV high-risk screening in this region was 9.6%, mainly for single infections. In addition, HPV16, HPV52, and HPV58 were closely related to the severity of cervical cytology. When vaccinated against HPV, the nine-valent vaccine is more effective in preventing infection. Health departments and medical institutions need to strengthen regular HPV screening and science publicity for young and middle-aged women, since both are crucial for preventing cervical cancer.

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A new era in cervical cancer prevention

Cited by 5 publications

References 5 publications

Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection

Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection

Renewal of the National Cervical Screening Program: health professionals’ knowledge about screening of specific populations in NSW, Australia

Epidemiological study of HPV infection in 40693 women in Putian: a population study based on screening for high-risk HPV infection

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