A new flavonoid from Stellera chamaejasme L., stechamone, alleviated 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in a murine model

Jo, Beom-Geun; Park, No-June; Jegal, Jonghwan; Choi, Sangho; Lee, Sang Woo; Kim, Su‐Nam; Yang, Min

doi:10.1016/j.intimp.2018.04.008

Cited by 19 publications

(11 citation statements)

References 31 publications

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“…Categorically, the BALB/c mice model ( n = 25) was most extensively used among the included studies, superseded by NC/Nga ( n = 20), hairless mice ( n = 6), Kunming mice ( n = 3), ICR mice ( n = 1), HR-1 mice ( n = 1), C57BL/6 ( n = 1) and NC/Tnd mice ( n = 1). It is also noteworthy that three individual studies conducted by Jegal et al (2017) , Jo et al (2018) and Lee JH et al (2019) , utilized two different mice species namely BALB/c and SKH-1 hairless mice. According to Erkes and Selvan (2014) , variation in the type of mouse strains could lead to a substantial difference in the immune stimulatory ability of haptens used to induce AD, which in these three studies, were DNCB and oxazolone.…”

Section: Resultsmentioning

confidence: 99%

Management of Atopic Dermatitis Via Oral and Topical Administration of Herbs in Murine Model: A Systematic Review

et al. 2022

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Over the past few decades, complementary and alternative medicine (CAM) using herbs, or their active constituents have garnered substantial attention in the management of a chronic and relapsing inflammatory skin disorder called atopic dermatitis (AD), particularly in attenuating disease recurrence and maintaining long-term remission. In Eastern Asian countries including China, Korea and Taiwan, herbal medicine available in both topical and oral preparation plays a significant role in treating skin diseases like AD as they possibly confer high anti-inflammatory properties and immunomodulatory functions. Conventional murine models of AD have been employed in drug discovery to provide scientific evidence for conclusive and specific pharmacological effects elicited by the use of traditional herbs and their active constituents. Coupled with the goal to develop safe and effective novel therapeutic agents for AD, this systematic review consists of a summary of 103 articles on both orally and topically administered herbs and their active constituents in the murine model, whereby articles were screened and selected via a specialized framework known as PICO (Population, Intervention, Comparator and Outcome). The objectives of this review paper were to identify the efficacy of oral and topical administered herbs along with their active constituents in alleviating AD and the underlying mechanism of actions, as well as the animal models and choice of inducer agents used in these studies. The main outcome on the efficacy of the majority of the herbs and their active constituents illustrated suppression of Th2 response as well as improvements in the severity of AD lesions, suppression of Immunoglobulin E (IgE) concentration and mast cell infiltration. The majority of these studies used BALB/c mice followed by NC/Nga mice (commonly used gender–male; commonly used age group – 6–8 weeks). The most used agent in inducing AD was 2, 4-Dinitrochlorobenzene (DNCB), and the average induction period for both oral and topical administered herbs and their active constituents in AD experiments lasted between 3 and 4 weeks. In light of these findings, this review paper could potentially assist researchers in exploring the potential candidate herbs and their active constituents using murine model for the amelioration of AD.

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Section: Resultsmentioning

confidence: 99%

Management of Atopic Dermatitis Via Oral and Topical Administration of Herbs in Murine Model: A Systematic Review

et al. 2022

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“…ESC is widely utilized in traditional Chinese medicine and confirmed to possess antibacterial, 24 antivirus, 25 and antitumors activities. 6,7 To explore the effects of ESC on HCC progression, the authors first detected its cytotoxicity to HCC cells and found that ESC inhibited cell proliferation in a dose-and time-dependent manner, and cell sur-vival rate had a sharp downtrend at 20 lg/mL ESC.…”

Section: Discussionmentioning

confidence: 99%

Extract of Stellera Chamaejasme L. Inhibits the Progression of Hepatocellular Carcinoma by Regulating miR-134-5p and JAK1/STAT3 Pathway

Huang

Chen²,

Zhang

et al. 2020

Cancer Biotherapy and Radiopharmaceuticals

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Background: Hepatocellular carcinoma (HCC) poses a growing threat to humans due to poor prognosis. Extract of stellera chamaejasme L. (ESC) is reported to inhibit metastasis of HCC. However, the underlying mechanism of ESC in regulating the progression of HCC needs to be further investigated. Methods: 3-(4, 5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to measure cell proliferation. Flow cytometry was employed to check cell apoptosis. Transwell assay was conducted to assess the abilities of cell migration and invasion. The protein levels of proliferating cell nuclear antigen, cleaved caspase 3 (c-caspase 3), E-cadherin, janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), and phosphorylated STAT3 were detected by Western blot. The interaction between miR-134-5p and JAK1 was predicted by starBase, which was verified by the dual-luciferase reporter assay and RNA pull-down assay. The messenger RNA levels of miR-134-5p and JAK1 were determined by quantitative real-time polymerase chain reaction. Results: The results showed that the higher concentration or the longer time treatment of ESC led to the lower survival rate of HCC cells. Besides, ESC induced apoptosis and impeded migration and invasion of HCC cells. Moreover, downregulation of miR-134-5p inverted the effects of ESC-mediated repression on HCC progression. Further studies indicated that miR-134-5p targeted the 3¢-untranslated region (3¢UTR) of JAK1 and reversed JAK1-mediated impacts on HCC progression. Simultaneously, ESC inactivated JAK1/STAT3 pathway by regulating the expression of miR-134-5p. Conclusion: ESC suppressed HCC progression by upregulating the expression of miR-134-5p and blocking JAK1/STAT3 pathway.

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“…Via activating Nrf2 signal, quercetin also availably resisted OS aggression and reduced inflammatory response induced by house dust mites in AD mice [139]. A new flavonoid, genkwanin 5-O-xylosyl (1→2) glucoside namely stechamone at 0.5% concentration was externally applied on the dorsal skin of AD-like murine models for 14 days, which showed that stechamone dramatically relieved AD-like skin manifestations, including pruritus, erythema, dryness, and lichenification, and mitigated the histopathological alterations like stratum corneum thickening, lymphocyte infiltration and mast cell degranulation, probably through fighting OS, diminishing inflammatory responses and repairing skin barrier [140]. Studies in vitro and in vivo revealed that topical application of ISO-1, an isoflavone extract from soybean, obviously alleviated DNCB-induced skin changes (e.g.…”

Section: Flavonoids In Atopic Dermatitismentioning

confidence: 99%

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

Xian

Guo

et al. 2021

Redox Report

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Background: Skin, as a crucial external defense organ, is more vulnerable to oxidative stress (OS) insult, reactive oxygen species (ROS)-mediated OS in particular. OS results from a redox imbalance caused by various extrinsic stimuli and occurs once the oxidants production overwhelming the antioxidants capacity, through mediating in DNA damage, lipid peroxidation (LPO), protein oxidation and a serial of signaling pathways activation/inactivation, thereby offering favorable conditions for the occurrence and development of numerous diseases especially some dermatoses, e.g. psoriasis, vitiligo, skin photodamage, skin cancer, systemic sclerosis (SSc), chloasma, atopic dermatitis (AD), pemphigus, etc. Targeting OS molecular mechanism, a variety of anti-OS agents emerge, in which flavonoids, natural plant extracts, stand out. Objectives: To discuss the possible mechanisms of OS mediating in dermatoses and summarize the properties of flavonoids as well as their applications in OS-related skin disorders. Methods: Published papers on flavonoids and OS-related skin diseases were collected and reviewed via database searching on PubMed, MEDLINE and Embase, etc. Results: It has been confirmed that flavonoids, belonging to polyphenols, are a class of plant secondary metabolites widely distributed in various plants and possess diverse bioactivities especially their potent antioxidant capacity. Moreover, flavonoids benefit to suppress OS via eliminating free radicals and mediating the corresponding signals, further excellently working in the prevention and management of OS-related skin diseases. Conclusion: Flavonoids have the potential therapeutic effects on oxidative stress-related dermatoses. However, more studies on specific mechanism as well as the dosage of flavonoids are needed in future.

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A new flavonoid from Stellera chamaejasme L., stechamone, alleviated 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in a murine model

Cited by 19 publications

References 31 publications

Management of Atopic Dermatitis Via Oral and Topical Administration of Herbs in Murine Model: A Systematic Review

Management of Atopic Dermatitis Via Oral and Topical Administration of Herbs in Murine Model: A Systematic Review

Extract of Stellera Chamaejasme L. Inhibits the Progression of Hepatocellular Carcinoma by Regulating miR-134-5p and JAK1/STAT3 Pathway

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

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