A new fluorescent anatomic pulmonary segmentectomy using PDD endoscope system™ and vitamin B2: evaluation in a clinical setting using living animal

Ohsima, Masahiro; Waseda, Ryuichi; Tanaka, Nobuhiro; Ueda, Hideyasu; Ooi, Akishi; Matsumoto, Isao

doi:10.1007/s00464-015-4194-x

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…One of these methods is the diagnosis endoscope system that allows clear and accurate identification both on the surface and inside the investigated system. In addition, it has been a simple and safe method for a variety of surgical operations. , Endoscopy is considered an effective approach in interventional surgery. Electrospinning is a cost-effective and simple method that has been developed for preparing polymer nanofibrous systems for various applications, such as sensors, electrode materials, filtration, cosmetics, drug delivery, and tissue scaffolding .…”

Section: Introductionmentioning

confidence: 99%

Development of Electrospun Nanofibrous-Walled Tubes for Potential Production of Photoluminescent Endoscopes

Khattab

Tolba

Gaffer

et al. 2021

Ind. Eng. Chem. Res.

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Novel and durable lightening photoluminescent electrospun nanofibrous-walled tubes were developed with the ability to glow like a flashlight helping to replace electric power in medical endoscopes. Simple preparation of an organic–inorganic photoluminescent nanocomposite was developed via encapsulation of rare-earth doped aluminum strontium oxide nanoscaled particles into polycaprolactone-cellulose acetate-based nanofibers. The luminescent nanofibrous-walled tubes demonstrated an excitation band at 355 nm and a photostability phosphorescence band at 517 nm. The UV–vis absorbance and emission spectra and CIE Lab color space parameters demonstrated photochromic colorimetric shifting from white under visible daylight to greenish-yellow under ultraviolet light. Both mechanical and superhydrophobic properties of the nanocomposite electrospun nanofibrous-walled tubes were explored. The nanofibrous-walled tubes exhibited an enhanced hydrophobic performance without adversely influencing its inherent characteristics. The morphology and chemical structure of the prepared phosphor nanoparticles and the performance of the phosphorescent electrospun nanofibrous-walled tubes were explored. The cytotoxicity of the generated photoluminescent aluminum strontium oxide pigment was explored. The produced nanofibrous-walled tubes demonstrated photostable long-persistent photoluminescence without fatigue upon exposure to an external ultraviolet light source.

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Section: Introductionmentioning

confidence: 99%

Development of Electrospun Nanofibrous-Walled Tubes for Potential Production of Photoluminescent Endoscopes

Khattab

Tolba

Gaffer

et al. 2021

Ind. Eng. Chem. Res.

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“…Several methods have been reported to help identify the intersegmental plane during anatomical VATS segmentectomy, including use of inflation-deflation of the lung with clamping and unclamping of the relevant bronchus, and endobronchial or systemic injection of ICG or other dyes. [2][3][4] Unfortunately, the inflationdeflation method may fail to correctly identify the plane, particularly in patients with emphysema, and may jeopardize visualization and surgical maneuvering during VATS. [1][2][3] On the other hand, intravenous injection of ICG implies systemic diffusion of the dye and requires several hours to allow uniform pulmonary distribution.…”

Section: Discussionmentioning

confidence: 99%

A new method of infrared-fluorescence-enhanced thoracoscopic segmentectomy

Elkhouly

Cristino

Pompeo

2018

Asian Cardiovasc Thorac Ann

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“…Vitamin B2 is a water-soluble substance that served as a coenzyme of oxidative phosphorylation and can be exited to illuminate by nearultraviolet light of which the wavelength is approximately 450 nm. Waseda et al introduced the fluorescence technique of vitamin B2 through bronchus in pig models ex vivo and in vivo, indicating that an extremely clear intersegmental plane could be observed in all test samples and remained in high contrast even one hour later (29,30). Yet, the clinical application of this method has not been carried out.…”

Section: Vitamin B2 Injectionmentioning

confidence: 99%

Intraoperative Identification of the Intersegmental Plane: From the Beginning to the Future

Zhang

Jin

et al. 2022

Front. Surg.

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Segmentectomy has played a crucial role in the treatment of early-stage lung cancer after the publication of JCOG0802, which indicated that patients with small-sized peripheral non-small-cell lung cancer could receive better survival from segmentectomy than lobectomy despite a higher local recurrence. The intraoperative identification of the intersegmental plane ensures complete resection of the lesion with sufficient margin so that it is deemed as the critical part of segmentectomy. Diverse methods have been developed to acquire distinguishable and lasting borderline between segments, but none of them is proved perfect. In this review, we searched and classified these techniques that emerged from the beginning when segmentectomy was used for bronchiectasis until now. Comparisons between different ways in mechanisms, facility, and safety were made to depict a comprehensive landscape for surgeons to select fit one. Furthermore, we presented our vision for the future of intersegmental plane identification.

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A new fluorescent anatomic pulmonary segmentectomy using PDD endoscope system™ and vitamin B2: evaluation in a clinical setting using living animal

Abstract: Our new fluorescence technique in a clinical setting involving a PDD endoscope system™ vitamin B2 enabled accurate and safe anatomic pulmonary segmentectomy, with enough strong and long fluorescence in living pig lungs.

Cited by 5 publications

References 12 publications

Development of Electrospun Nanofibrous-Walled Tubes for Potential Production of Photoluminescent Endoscopes

Development of Electrospun Nanofibrous-Walled Tubes for Potential Production of Photoluminescent Endoscopes

A new method of infrared-fluorescence-enhanced thoracoscopic segmentectomy

Intraoperative Identification of the Intersegmental Plane: From the Beginning to the Future

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