A New Frontier in Soy Bioactive Peptides that May Prevent Age-related Chronic Diseases

Abstract

During gastrointestinal digestion or food processing of proteins, small peptides can be released and may act as regulatory compounds with hormone‐like activities. Numerous biologically active peptides (bioactive peptides) have been identified. Most bioactive peptides are derived from milk and dairy products, with the most common being angiotensin converting enzyme inhibitory peptides. Soybean protein and soybean derived peptides also play an important role in soybean physiological activities, particularly those related to the prevention of chronic diseases. However, the bioactive potential of soybean derived bioactive peptides is yet to be fully appreciated. After a general introduction of approaches and advances in bioactive peptides from food sources, this review focuses on bioactive peptides derived from soybean proteins and their physiological properties. Technological approaches to generate bioactive peptides, their isolation, purification, characterization, and quantification, and further application in food and drug design are also presented. Safety concerns, such as potential toxicity, allergenicity, and sensory aspect of these peptides are likewise discussed.

Supplementation of enzyme-treated soy protein saves dietary protein and promotes digestive and absorptive ability referring to TOR signaling in juvenile fish

“…As we know, the enzyme-treated proteins have much better utilization and rich in functional peptides which have antioxidant activity, immuneregulatory activity, and so on (Wang and Mejia 2005;Singh et al 2014). However, there is no study concerning effects of enzyme-treated plant protein on the protein saving in fish feeds.…”

OBTENÇÃO DE HIDROLISADOS DE CONCENTRADO PROTEICO DE SORO DE LEITE COM ATIVIDADE INIBITÓRIA DA ENZIMA CONVERSORA DE ANGIOTENSINA: AÇÃO DAS PROTEASES DO Bacillus licheniformis E DO Aspergillus oryzae

“…Além dessas aplicações, vários trabalhos relatam o isolamento de peptídeos bioativos, provenientes do tratamento enzimático de proteínas alimentares, com capacidade de desempenhar diversas atividades benéficas no organismo, como antitrombótica, anti-hipertensiva, antimicrobiana, antiviral, antitumoral, anticoagulante, opioide, imunomoduladora, hipocolesterolêmica e antioxidante (CLARE; SWAISGOOD, 2000; PIHLANTO-LEPPÄLLÄ, 2001;HA;ZEMEL, 2003;SILVA, MALCATA, 2005;MEJIA, 2005;HARTMANN;MEISEL, 2007;SAINT-SAUVEUR et al, 2008).…”

Soybean peptide fractions inhibit human blood, breast and prostate cancer cell proliferation

“…Certain other bioactive molecules are from natural sources like plants (Ng et al 2003;Ohba et al 2004;Silva-Sánchez et al 2008). One of the major approaches to produce bioactive peptides was enzymatic hydrolysis or fermentation, especially from sources like soybean, wheat, corn, rice, sunflower, milk, eggs, and meat (Gibbs et al 2004;Wang and de Mejia 2005;de Mejia and de Lumen 2006;Kannan et al 2008Kannan et al , 2009Kannan et al , 2010Hettiarachchy 2013).…”