A new heteropolysaccharide from the seed husks of<i>Plantago asiatica</i>L. with its thermal and antioxidant properties

Niu, Yuge; Li, Na; Alaxi, Sierkemideke; Huang, G.; Chen, Lei; Feng, Ziqian

doi:10.1039/c7fo01171g

Cited by 16 publications

(9 citation statements)

References 36 publications

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“…In the present study, we found that fermented ginseng polysaccharides show superior potency than nonfermented ginseng polysaccharides on antioxidant via enhancing the hydroxyl radical, superoxide anion scavenging ability, and total antioxidant capacity. Niu et al (2017) reported that the antioxidant ability may positively related to the content of uronic acid, which means high uronic acid content exhibited higher antioxidant capacity. So, we hypothesized that the antioxidant activity of FGP was improved due to the increasing of uronic acid.…”

Section: Discussionmentioning

confidence: 99%

Enhanced uronic acid content, antioxidant, and anti‐inflammatory activities of polysaccharides from ginseng fermented by Saccharomyces cerevisiae GIW‐1

You

et al. 2020

J. Food Process. Preserv.

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In this study, Panax ginseng was fermented using Saccharomyces cerevisiae GIW-1. The crude ginseng polysaccharides were extracted and purified by DEAE-Sepharose Fast Flow, and the monosaccharide analysis was performed by GC/MS. In addition, the in vitro antioxidant and the anti-inflammatory activities in mice of polysaccharides were determined. Results showed that the uronic acid content of fermented polysaccharide was significantly increased than nonfermented ginseng, showing that the acid polysaccharide was increased after fermentation. And the ginseng polysaccharides between fermented and nonfermented showed different physiological activity after fermentation. Results of the in vitro antioxidant assay showed ginseng polysaccharides after S. cerevisiae GIW-1 fermentation were found to possess higher capacity on scavenging hydroxyl and superoxide anion free radicals. Furthermore, fermented ginseng polysaccharides attenuated increases of liver index and the level of serum AST, and some inflammatory-related factors including TNF-α, IL-1β, and IL-6 in lipopolysaccharide (LPS)-induced mice. Practical applications Microorganism as one of the important tools of biological method has been considered as a more effective and economical way to convert and synthesize natural compounds with more biologically activities. In this paper, we analyze the ginseng polysaccharides after fermented by S. cerevisiae GIW-1. Result showed that fermented ginseng polysaccharides existed superior potency than nonfermented ginseng polysaccharides on antioxidant and anti-inflammatory activities. Moreover, the content of uronic acid in fermented ginseng polysaccharides have increased. These data maybe provide new insight into the natural antioxidants and impetus the development of ginseng in food industry with improving added value of ginseng products. 1 | INTRODUC TI ON Ginseng, the root of Panax ginseng C. A. Meyer, is known as the king of medicinal herb as its physiological activities (Han et al., 2018; Li, Kim, Park, & Ji, 2017). A number of studies have been demonstrated that ginseng not only enhances the myocardium, anti-obesity, antidiabetic, and antitumor effects, but also improves our immunity, as well as regulates nervous system (Dai, Zhang, Williams, Yuan, &

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Section: Discussionmentioning

confidence: 99%

Enhanced uronic acid content, antioxidant, and anti‐inflammatory activities of polysaccharides from ginseng fermented by Saccharomyces cerevisiae GIW‐1

You

et al. 2020

J. Food Process. Preserv.

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“…seed have reported different results. For example, a new type of low molecular weight heteropolysaccharide was found in the seeds of P. asiatica , which was mainly composed of rhamnose, galactose, and galacturonic acid (similar to pectin) ( Niu et al, 2017 ), and a new polysaccharide was also found in psyllium husk, which was mainly composed of xylose, glucose, and rhamnose ( Patel, Tanna, Gupta, Mishra, & Jha, 2019 ). It is worth mentioning that in both studies, these polysaccharides were isolated from the ground seeds.…”

Section: Extraction Physicochemical Properties and Structural Featuresmentioning

confidence: 99%

Review of structure and bioactivity of the Plantago (Plantaginaceae) polysaccharides

Zhang

Sun

et al. 2021

Food Chemistry: X

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“…Plantaginis Semen (PS) is a traditional Chinese herbal medicine with diuretic, anti-inflammatory, and immune regulation effects [5][6][7]. After extensive research, it was found that PS contains a variety of active components, such as polysaccharides, iridoids, triterpenes, flavonoids, and alkaloids, and many of these ingredients are verified to have certain effects on xanthine oxidase (XOD) activity and uric acid excretion [8,9]. Under the guidance of traditional Chinese medicine theory, PS is a diuretic drug, and it has the characteristics of mild drug and little side effects.…”

Section: Introductionmentioning

confidence: 99%

Study on Network Pharmacological Analysis and Preliminary Validation to Understand the Mechanisms of Plantaginis Semen in Treatment of Gouty Nephropathy

Zhao

Kong

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Plantaginis Semen (PS) has been used to promote diuresis and clear away dampness. Recent reports have shown that PS can be used to treat gouty nephropathy (GN). However, the action and mechanism of PS have not been well defined in treating GN. The present study aimed to define the molecular mechanisms of PS as a potential therapeutic approach to treat GN. A combination of network pharmacology and validation experiments in GN is used to understand the potential mechanism. Information on pharmaceutically active compounds in PS and gene information related to GN was obtained from public databases. The compound target network and protein-protein interaction network were constructed to study the mechanism of action of PS in the treatment of GN. The mechanism of action of PS in the treatment of GN was analyzed via Gene Ontology (GO) biological process annotation and Kyoto Gene and Genomics Encyclopedia (KEGG) pathway enrichment. Validation experiments were performed to verify the core targets. The GN rat model was prepared by the method of combining yeast and adenine. Hematoxylin-eosin (HE) staining was used to observe the morphology of renal tissue in rats. ELISA was applied to detect TGF-β1, TNF-α, and IL-1β levels in renal tissue. The expressions of TGF-β1, TNF-α, and IL-1β were determined using immunohistochemistry. Through the results of network pharmacology, we obtained 9 active components, 118 predicted targets, and 149 GN targets from the public database. Based on the protein-protein interaction (PPI), 26 hub genes for interaction with PS treating for GN were screened, including MMP9, TNF, IL1β, and IL6. The enrichment analysis results showed that the treatment of GN with PS was mainly involved in the TGF-β1 signaling pathway, MAPK signaling pathway, TNF signaling pathway, NF-κB signaling pathway, and PI3K Akt signaling pathway. Validation experiment results showed that PS could reduce the content of urinary protein and UA and deregulate the expression of TGF-β1, TNF-α, and IL-1β in the treatment of GN. The molecular mechanism of PS in the treatment of GN indicated the synergistic features of multicomponent, multitarget, and multipathway of traditional Chinese medicine, which provided an essential scientific basis for further elucidating the mechanism of PS in the treatment of GN.

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A new heteropolysaccharide from the seed husks ofPlantago asiaticaL. with its thermal and antioxidant properties

Cited by 16 publications

References 36 publications

Enhanced uronic acid content, antioxidant, and anti‐inflammatory activities of polysaccharides from ginseng fermented by Saccharomyces cerevisiae GIW‐1

Enhanced uronic acid content, antioxidant, and anti‐inflammatory activities of polysaccharides from ginseng fermented by Saccharomyces cerevisiae GIW‐1

Review of structure and bioactivity of the Plantago (Plantaginaceae) polysaccharides

Study on Network Pharmacological Analysis and Preliminary Validation to Understand the Mechanisms of Plantaginis Semen in Treatment of Gouty Nephropathy

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