A New Iatrogenous Lesion in Newborns Requiring Assisted Ventilation

La, Metlay; Ta, Macpherson; Doshi, Neelam; Milley,

doi:10.1056/nejm198307143090214

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2020

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Cited by 51 publications

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“…Pediatric pseudomembranous necrotizing tracheitis is rare. The disease was first reported as a complication of prolonged assisted ventilation in newborns in 1983 ( 3 ). Despite mucosal trauma from mechanical ventilation, mucosal damage from an antecedent viral infection may contribute to the pathogenesis of this disease ( 4 , 5 ).…”

Section: Discussionmentioning

confidence: 99%

The Important Role of Endoscopy in Management of Pediatric Pseudomembranous Necrotizing Tracheitis

Chen

2020

Front. Pediatr.

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Pseudomembranous necrotizing tracheitis is a rare, but life-threatening cause of central airway obstruction. Here, we reported three cases of pediatric pseudomembranous necrotizing tracheitis. The infectious etiologies were Staphylococcus aureus secondary to influenza A virus and Aspergillus fumigatus. Endoscopy was used in diagnosis and management of all patients and two patients survived. The improvement in mortality rate of these diseases need early recognition and prompt treatment with mechanical debridement by endoscope and early initiation of broad spectrum antibiotics. Endoscopy is a promising tool to diagnose and remove the pseudomembrane, therefore relieving central airway obstruction.

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Section: Discussionmentioning

confidence: 99%