A new injectable quick hardening anti-collapse bone cement allows for improving biodegradation and bone repair

Chen, Huaizhi; Shen, Miaoda; Shen, Jian; Li, Yifan; Wang, Ruo; Ye, Meihan; Li, Jiafeng; Zhong, Cheng; Bao, Zhaonan; Yang, Xianyan; Li, Xigong; Gou, Zhongru; Xu, Sanzhong

doi:10.1016/j.bioadv.2022.213098

Cited by 13 publications

(10 citation statements)

References 48 publications

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“…Indeed, it is reasonable to assume that the multifunctional biodegradable fibers, such as therapeutic drugs, growth factors, and even antibacterial agents, can be easily integrated into the gypsum fibers and then endow plenty of biological property requirements in some bone defect conditions . Also, the osteogenic activity of the CPC substrate may also be taken into consideration, and some potential approaches are valuable to carry out, for instance, functional ion doping. − Therefore, there is a wide bottom for biomaterial society to expand the biodegradable fiber modification strategy and enhance the biological performances of CPC-based implants in the near future.…”

Section: Discussionmentioning

confidence: 99%

Preferentially Biodegradable Gypsum Fibers Endowing Invisible Microporous Structures and Enhancing Osteogenic Capability of Calcium Phosphate Cements

Zhang,

Xie,

Jiao

et al. 2024

ACS Biomater. Sci. Eng.

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It is known that hydroxyapatite-type calcium phosphate cement (CPC) shows appreciable self-curing properties, but the phase transformation products often lead to slow biodegradation and disappointing osteogenic responses. Herein, we developed an innovative strategy to endow invisible micropore networks, which could tune the microstructures and biodegradation of α-tricalcium phosphate (α-TCP)-based CPC by gypsum fibers, and the osteogenic capability of the composite cements could be enhanced in vivo. The gypsum fibers were prepared via extruding the gypsum powder/carboxylated chitosan (CC) slurry through a 22G nozzle (410 μm in diameter) and collecting with a calcium salt solution. Then, the CPCs were prepared by mixing the α-TCP powder with gypsum fibers (0−24 wt %) and an aqueous solution to form self-curing cements. The physicochemical characterizations showed that injectability was decreased with an increase in the fiber contents. The μCT reconstruction demonstrated that the gypsum fiber could be distributed in the CPC substrate and produce long-range micropore architectures. In particular, incorporation of gypsum fibers would tune the ion release, produce tunnel-like pore networks in vitro, and promote new bone tissue regeneration in rabbit femoral bone defects in vivo. Appropriate gypsum fibers (16 and 24 wt %) could enhance bone defect repair and cement biodegradation. These results demonstrate that the highly biodegradable cement fibers could mediate the microstructures of conventional CPC biomaterials, and such a bicomponent composite strategy may be beneficial for expanding clinical CPC-based applications.

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Section: Discussionmentioning

confidence: 99%

Preferentially Biodegradable Gypsum Fibers Endowing Invisible Microporous Structures and Enhancing Osteogenic Capability of Calcium Phosphate Cements

Zhang,

Xie,

Jiao

et al. 2024

ACS Biomater. Sci. Eng.

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“…The composites mediated by α-CSH displayed a plate-like structure with the prolongation of degradation time (Figure 4(c)). 15 In contrast, rod-like materials appeared in the undegraded materials with the content of α-CSH at 20 wt%, larger flake-like crystals were distributed in a higher ratio of α-CSH composites. When SFFs was curing liquid (Figure 4(b)), the weight loss ratio of composite bone cement decreased with α-CSH at 0 ∼ 15 wt% and increased at 20 wt% and 25 wt%.…”

Section: The Degradation Rate and Surface Morphologymentioning

confidence: 95%

“…Then CSD will be collapsed and peeled off when it vibrates in the PBS buffer, and the newly formed pores will also increase the contact area between the composite and PBS, and speed up the degradation rate of α-TCP. 15 Additionally, it is difficult to employ α-TCP-based bone cement in a load-bearing bone repair field because of its low compressive strength. Therefore, improving its compressive strength has always been the crux part.…”

Section: Introductionmentioning

confidence: 99%

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The study of self-regulating α-TCP based composite by micro/nano scaled silk fibroin and α-CSH on physicochemical and biological properties of bone cement

et al. 2023

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A novel self-hardening α-tricalcium phosphate (α-TCP) bone cement complexed with different content of α-calcium sulfate hemihydrate (α-CSH) and micrometer hydroxyapatite mineralized silk fibroin (HA-SF) using micro/SF as curing liquid has been investigated in this work, which was capable of tunable setting time, degradation, mechanical property and ability to anti-washout. After addition 0 ∼ 25% α-CSH to the α-TCP cement with SFFs as curing liquid, it shortened the setting time of the modified composite to 10 ∼ 30 min. Furthermore, the addition of SFFs improved the compressive strength of the composite from 5.41 MPa to 9.44 MPa. The composites with both Na2HPO4 and SFFs as curing liquid showed good anti-collapse performance. The weight loss ratio of bone cement was −0.18 ∼ 12.08% in 4 weeks when the content of α-CSH in α-TCP/α-CSH was between 0 ∼ 25 wt%. During the degradation of α-CSH, the amorphous α-TCP were deposited as hydroxyapatite to formed a plate-like products on the surface of composite. Compared to the composite with Na2HPO4 solution as the curing liquid, alkaline phosphatase (ALP) activity of the composites using SFFs as curing liquid were maintained at high levels on the 14th day especially when the Ca/P ratio was 1.7. This study provides a theoretical basis for the regeneration of bone defects guided by bone cement materials.

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“…7 In comparison, a-CSH plates have been used as construction materials and bone cement owing to their high compressive/bending strength. 8 Moreover, the biodegradation rate of CSH is close to the growth rate of bone, which is conducive to the repair of bone tissue. In theory, CSH can be completely degraded and absorbed and has no obvious inflammatory stimulation and foreign body reaction to the surrounding tissues.…”

Section: Introductionmentioning

confidence: 99%

Glucose microenvironment sensitive degradation of arginine modified calcium sulfate reinforced poly(lactide-co-glycolide) composite scaffolds

Zhu,

Li,

Zhou

et al. 2024

J. Mater. Chem. B

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A new injectable quick hardening anti-collapse bone cement allows for improving biodegradation and bone repair

Cited by 13 publications

References 48 publications

Preferentially Biodegradable Gypsum Fibers Endowing Invisible Microporous Structures and Enhancing Osteogenic Capability of Calcium Phosphate Cements

Preferentially Biodegradable Gypsum Fibers Endowing Invisible Microporous Structures and Enhancing Osteogenic Capability of Calcium Phosphate Cements

The study of self-regulating α-TCP based composite by micro/nano scaled silk fibroin and α-CSH on physicochemical and biological properties of bone cement

Glucose microenvironment sensitive degradation of arginine modified calcium sulfate reinforced poly(lactide-co-glycolide) composite scaffolds

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