A new light triggered approach to develop a micro porous tough hydrogel

Dou, Qingqing; Low, Zhi Wei Kenny; Zhang, Kangyi; Loh, Xian Jun

doi:10.1039/c7ra03214e

Cited by 21 publications

(16 citation statements)

References 48 publications

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“…In addition, the PPy was homogenously distributed throughout the entire film even up to 6.7 mm thickness (Figure b), showing significantly improved uniformity compared to previous methods with 10–100 µm penetration depth, indicating the formation of a truly interpenetrating network of PPy/APA. The ice‐templating method creates appropriate open macroporous pores with orientation, which not only supports the network from being collapsed when drying, but also provides sufficient space for gas molecule diffusion, in contrast with most previous close‐pore structures …”

Section: Resultsmentioning

confidence: 99%

“…The ice-templating method creates appropriate open macroporous pores with orientation, which not only supports the network from being collapsed when drying, but also provides sufficient space for gas molecule diffusion, in contrast with most previous close-pore structures. [39,40] The chemical structures of pristine APA, APA with addition of PVA, and the aerogel after coating with PPy were analyzed using the Fourier transfer infrared (FTIR) spectra (Figure 2c). All the four samples had the peak at ≈3185 and ≈3327 cm −1 , which could be assigned to the characteristic peaks of NH bonds.…”

Section: Ppy Loadingmentioning

confidence: 99%

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Wood‐Inspired Morphologically Tunable Aligned Hydrogel for High‐Performance Flexible All‐Solid‐State Supercapacitors

Zhao

Alsaid

Yao

et al. 2020

Adv Funct Materials

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Oriented microstructures are widely found in various biological systems for multiple functions. Such anisotropic structures provide low tortuosity and sufficient surface area, desirable for the design of high‐performance energy storage devices. Despite significant efforts to develop supercapacitors with aligned morphology, challenges remain due to the predefined pore sizes, limited mechanical flexibility, and low mass loading. Herein, a wood‐inspired flexible all‐solid‐state hydrogel supercapacitor is demonstrated by morphologically tuning the aligned hydrogel matrix toward high electrode‐materials loading and high areal capacitance. The highly aligned matrix exhibits broad morphological tunability (47–12 µm), mechanical flexibility (0°–180° bending), and uniform polypyrrole loading up to 7 mm thick matrix. After being assembled into a solid‐state supercapacitor, the areal capacitance reaches 831 mF cm−2 for the 12 µm matrix, which is 259% times of the 47 µm matrix and 403% times of nonaligned matrix. The supercapacitor also exhibits a high energy density of 73.8 µWh cm−2, power density of 4960 µW cm−2, capacitance retention of 86.5% after 1000 cycles, and bending stability of 95% after 5000 cycles. The principle to structurally design the oriented matrices for high electrode material loading opens up the possibility for advanced energy storage applications.

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Section: Resultsmentioning

confidence: 99%

Section: Ppy Loadingmentioning

confidence: 99%

Wood‐Inspired Morphologically Tunable Aligned Hydrogel for High‐Performance Flexible All‐Solid‐State Supercapacitors

Zhao

Alsaid

Yao

et al. 2020

Adv Funct Materials

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“…For these reasons, light has been extensively applied in a variety of biomedical applications beyond drug delivery, including image-guided surgery, polymerization and degradation of tissue engineering scaffolds, and photodynamic therapy for cancer. 13,14 In this review, the scope has been limited to light-triggered drug delivery systems that have demonstrated triggered cargo release for each of the major light-responsive drug delivery mechanisms: photochemically triggered release, photoisomerization and photothermal release (Fig. 1).…”

Section: Interaction Of Light With Photoresponsive Hydrogelsmentioning

confidence: 99%

Photoresponsive Hydrogels as Drug Delivery Systems

et al. 2020

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Hydrogels have been developed and used in tissue engineering and regenerative medicine to deliver therapeutics to injured or diseased tissue because of their versatility and properties that can be tailored to match the natural extracellular matrix. Hydrogels can be made with a variety of physical and chemical properties combined with light responsiveness ideal for applications in different fields of medicine that require the spatiotemporal control of therapeutics. Light, as a stimulus, is relatively inexpensive, contact-free, noninvasive with high spatial resolution and temporal control, convenient and easy to use, and allows deep tissue penetration that is relatively harmless. Photoresponsive hydrogels are ideal candidates for on-demand drug delivery systems that are capable of sustained and controlled drug release, minimizing the side effects, and ensuring the activity and efficient delivery of drugs to the target tissue.

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“…11 Hydrogels are particularly well suited to provide these characteristics and have consequently drawn attention as cell scaffolds for in vitro and in vivo studies. 12 Hydrogels based on self-assembling peptides have gained increasing attention given their capacity to form nanofibrillar networks with biologically relevant viscoelastic and mass transport properties and precisely display bioactive epitopes. 13,14 Peptide amphiphiles (PAs) are one class of selfassembling peptides that have demonstrated the ability to emulate ECM bioactivity 15,16 and have tuneable structural and physical properties.…”

Section: ■ Introductionmentioning

confidence: 99%

Host–Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels

Redondo-Gómez

Padilla-Lopátegui

Azevedo

et al. 2020

ACS Biomater. Sci. Eng.

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A key feature in biomaterial design is the incorporation of bioactive signals into artificial constructs to stimulate tissue regeneration. Most currently used hydrogel cell culture systems depend on the covalent attachment of extracellular matrix (ECM)-derived peptides to either macromolecular units or smaller self-assembling building blocks, thereby restricting biosignal presentation and adaptability.However, new ways to rationally incorporate adhesion epitopes through non-covalent interactions would offer opportunities to better recreate the dynamic and reversible nature of the native ECM.Here we report on a non-covalent epitope presentation approach mediated by host-guest interactions.Using peptide amphiphile hydrogels we demonstrate that the adamantane/β-cyclodextrin (Ada/βCD) pair can be used to anchor RGDS cell adhesion signals onto self-assembled hydrogels via host-guest interactions. We evaluate hydrogel morphological and rheological properties as well as fibroblast attachment, organisation, and spreading when cultured atop these scaffolds. This host-guest mediated epitope display might lead to new self-assembling hydrogels for improved cell culture applications as well tissue engineering and regenerative medicine.

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A new light triggered approach to develop a micro porous tough hydrogel

Abstract: A porous tough hydrogel (alginate–polyacrylamide) is successfully synthesized using a photo-gelling polymer as a templating agent.

Cited by 21 publications

References 48 publications

Wood‐Inspired Morphologically Tunable Aligned Hydrogel for High‐Performance Flexible All‐Solid‐State Supercapacitors

Wood‐Inspired Morphologically Tunable Aligned Hydrogel for High‐Performance Flexible All‐Solid‐State Supercapacitors

Photoresponsive Hydrogels as Drug Delivery Systems

Host–Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels

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