A New Look at the Genus Solobacterium: A Retrospective Analysis of Twenty-Seven Cases of Infection Involving S. moorei and a Review of Sequence Databases and the Literature

Abstract

Solobacterium moorei is an anaerobic Gram-positive bacillus present within the oral and the intestinal microbiota that has rarely been described in human infections. Besides its role in halitosis and oral infections, S. moorei is considered to be an opportunistic pathogen causing mainly bloodstream and surgical wound infections. We performed a retrospective study of 27 cases of infections involving S. moorei in two French university hospitals between 2006 and 2021 with the aim of increasing our knowledge of this unrecognized opportunistic pathogen. We also reviewed all the data available in the literature and in genetic and metagenomic sequence databases. In addition to previously reported infections, S. moorei had been isolated from various sites and involved in intra-abdominal, osteoarticular, and cerebral infections more rarely or not previously reported. Although mostly involved in polymicrobial infections, in seven cases, it was the only pathogen recovered. Not included in all mass spectrometry databases, its identification can require 16S rRNA gene sequencing. High susceptibility to antibiotics (apart from rifampicin, moxifloxacin, and clindamycin; 91.3%, 11.8%, and 4.3% of resistant strains, respectively) has been noted. Our global search strategy revealed S. moorei to be human-associated, widely distributed in the human microbiota, including the vaginal and skin microbiota, which may be other sources for infection in addition to the oral and gut microbiota.

Bacterial pathogens in pediatric appendicitis: a comprehensive retrospective study

“…Being part of the tongue microbiota with beta-galactosidase activity potentially also producing volatile sulfur compounds, it is accused to cause halitosis ( Barrak et al., 2020 ). Even though it is known to be an opportunistic pathogen in bloodstream and surgical site infections with excellent susceptibility to most antibiotics, there are some reports of Solobacterium moorei as being the only recovered bacteria in complicated infection ( Alauzet et al., 2021 ). To our knowledge, our 6 patients of whom 3 suffered from complications, are the first appendicitis patients with Solobacterium moorei reported in literature.…”

Composition of nasopharyngeal microbiota in individuals with SARS-CoV-2 infection across three COVID-19 waves in India

“…Cnuella was higher in abundance only in the CP group, while its abundance decreased in the CN group. Notably, some organisms belonging to the genera Paenibacillus , Peptostreptococcus , and Solobacterium are known to be opportunistic pathogens [27], [28], [29]. Further, some of these driver taxonomic groups, viz., Cnuella , Marmoricola , and Paenibacillus lost their importance in the microbiome association network corresponding to the third wave (Supplementary Fig.…”

Raw potato starch diet supplement in weaned pigs could reduce Salmonella Typhimurium infection by altering microbiome composition and improving immune status

“…Further, Harryflintia abundance reduced when mice were fed high concentrations of RPS (0–10%) ( 35 ). Although the abundant species Campylobacter lanienae ( P = 0.0222) and Solobacterium moorei ( P = 0.0278) are common in the gastrointestinal tract of pigs, they have emerged as a potential cause of human gastroenteritis ( 32 , 36 ).…”